General Information of HIF (ID: HIFC0063)
HIF Name	CD25+ T cells
HIF Synonym(s)	CD25+ T cell, CD25+ T cells
HIF Classification	T cells (TCs)
Description	CD4+CD25+ immunoregulatory T cells represent a unique lineage of thymic-derived cells that potently suppress both in vitro and in vivo effector T cell function. We analyzed CD4+CD25+ and CD4+CD25 T cells by DNA microarray, identifying 29 genes differentially expressed in the resting subpopulations, and 77 that were differentially expressed following activation. Most of these genes were elevated in the CD4+CD25+ population, suggesting a previously activated phenotype. Among these were a number of genes that antagonize signaling, including members of the SOCS family, which may contribute to their anergic phenotype. Multiple cell surface receptors also had increased expression in CD4+CD25+ cells, including GITR, a member of the TNF receptor superfamily. Importantly, antibodies to GITR abrogated suppression, demonstrating a functional role for this receptor in regulating the CD4+CD25+ T cell subset.				[1]

Microbe Species (MIC) Regulated by This HIF
Capnocytophaga ochracea (CFB bacteria)			MIC00328
Description	Lipopolysaccharides from Capnocytophaga ochracea attenuated CD25 expression.				[2]
Eubacterium rectale (firmicutes)			MIC00578
Description	Eubacterium rectale is associated with CD25+ T-cells responses.				[3]

References
1	CD4(+)CD25(+) immunoregulatory T Cells: new therapeutics for graft-versus-host disease.J Exp Med. 2002 Aug 5;196(3):401-6. doi: 10.1084/jem.20020090.
2	Lipopolysaccharides from periodontopathic bacteria Porphyromonas gingivalis and Capnocytophaga ochracea are antagonists for human toll-like receptor 4. Infect Immun. 2002 Jan;70(1):218-25. doi: 10.1128/iai.70.1.218-225.2002.
3	Specific prebiotics modulate gut microbiota and immune activation in HAART-naive HIV-infected adults: results of the "COPA" pilot randomized trial. Mucosal Immunol. 2011 Sep;4(5):554-63. doi: 10.1038/mi.2011.15. Epub 2011 Apr 27.

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