Details of Microbe Species (MIC)

General Information of MIC (ID: MIC00328)
MIC Name Capnocytophaga ochracea (CFB bacteria)
MIC Synonyms Fusiformis nucleatus var. ochraceus
Body Site Oral Cavity
Lineage Kingdom: Bacteria
Phylum: Bacteroidetes
Class: Flavobacteriia
Order: Flavobacteriales
Family: Flavobacteriaceae
Genus: Capnocytophaga
Species: Capnocytophaga ochracea
Oxygen Sensitivity Aerotolerant; Anaerobe
Microbial Metabolism Saccharolytic; Fermentative
Gram Negative
Host Relationship Opportunistic pathogen
Genome Size (bp) 2612925
Description Capnocytophaga ochracea is a Gram-negative, fusiform-to-rod shaped bacterium. This capnophilic aerotolerant anaerobe is found in the oral cavity of humans and contributes to early plaque formation on teeth by being a physical intermediate link between several Streptococcus species and F. nucleatum. In addition to oral disease, C. ochracea is known to cause sepsis in immunocompromised patients.
External Links Taxonomy ID
1018
Genome Assembly ID
ASM2328v1
GOLD Organism ID
Go0001176
Disease Relevance
          Periodontal disease  [ICD-11: DA0C]
             Description Capnocytophaga ochracea was associated with periodontal disease. [1]
Host Genetic Factors (HGFs)
          rs113861361
             HGF ID HGF2223 HGF Info       Class Single Nucleotide Polymorphism (SNP)
             Description The rs113861361 SNP was significantly associated with the abundance of Capnocytophaga ochracea (p-value<1.00E-08). [2]
Host Immune Factors (HIFs)
          Interferon-6
             HIF ID HIFM0151 HIF Info       Class Cytokine (Cyt)
             Description Capnocytophaga ochracea could kill or inactivate enzymatic activity to inhibite the IL-6 expression. [3]
          Immunoglobulin G3
             HIF ID HIFM0267 HIF Info       Class Immunoglobulin (Ig)
             Description The activity of proteolytic enzymes from Capnocytophaga ochracea could effect enzymolysis of human immunoglobulin G3(lgG3). [4]
          Immunoglobulin G2
             HIF ID HIFM0268 HIF Info       Class Immunoglobulin (Ig)
             Description The activity of proteolytic enzymes from Capnocytophaga ochracea could effect enzymolysis of human immunoglobulin G2(lgG2). [4]
          Immunoglobulin G1
             HIF ID HIFM0269 HIF Info       Class Immunoglobulin (Ig)
             Description The activity of proteolytic enzymes from Capnocytophaga ochracea could effect enzymolysis of human immunoglobulin G1(lgG1). [4]
          Immunoglobulin G
             HIF ID HIFM0270 HIF Info       Class Immunoglobulin (Ig)
             Description The activity of proteolytic enzymes from Capnocytophaga ochracea could effect enzymolysis of human immunoglobulin G(lgG). [4]
          Immunoglobulin G4
             HIF ID HIFM0278 HIF Info       Class Immunoglobulin (Ig)
             Description The activity of proteolytic enzymes from Capnocytophaga ochracea could effect enzymolysis of human immunoglobulin G4(lgG4). [4]
          CD25+ T cells
             HIF ID HIFC0063 HIF Info       Class T cells (TCs)
             Description Lipopolysaccharides from Capnocytophaga ochracea attenuated CD25 expression. [3]
Environmental Factor(s)
             Disbiome ID
      357
             gutMDisorder ID
      gm0154
References
1 Subgingival microbial profile of obese women with periodontal disease. J Periodontol. 2018 Feb;89(2):186-194. doi: 10.1002/JPER.17-0236. Epub 2018 Feb 22.
2 Host genetic variation and its microbiome interactions within the Human Microbiome Project.Genome Med. 2018 Jan 29;10(1):6. doi: 10.1186/s13073-018-0515-8.
3 Lipopolysaccharides from periodontopathic bacteria Porphyromonas gingivalis and Capnocytophaga ochracea are antagonists for human toll-like receptor 4. Infect Immun. 2002 Jan;70(1):218-25. doi: 10.1128/iai.70.1.218-225.2002.
4 Immunoglobulin-degrading enzymes in localized juvenile periodontitis.J Periodontal Res. 1992 May;27(3):176-83. doi: 10.1111/j.1600-0765.1992.tb01666.x.

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