General Information of HIF (ID: HIFM0267)
HIF Name	Immunoglobulin G3
HIF Synonym(s)	IgG3
HIF Classification	Immunoglobulin (Ig)
Description	Immunoglobulin G3(IgG3) is the subclasses of microbiota-specific IgG.Microbiota-specific IgG displays remarkable specificities against proteins of bacterial origin,and can directly interact with bacteria through recognition of the bacterial antigen.				[1]

Microbe Species (MIC) Regulated by This HIF
Capnocytophaga ochracea (CFB bacteria)			MIC00328
Description	The activity of proteolytic enzymes from Capnocytophaga ochracea could effect enzymolysis of human immunoglobulin G3(lgG3).				[2]
Erysipelothrix rhusiopathiae (firmicutes)			MIC00559
Description	The abundance of Erysipelothrix is associated with IgG3 response.				[3]
Escherichia coli (enterobacteria)			MIC00516
Description	Escherichia coli was associated with IgG3 response.				[1]
Moraxella catarrhalis (gamma-proteobacteria)			MIC00837
Description	IgG3 is the predominant antibody response against Moraxella catarrhalis.				[4]
Mycobacterium leprae (actinobacteria)			MIC00851
Description	Disease progression in leprosy caused by Mycobacterium leprae showed a significant correlation with selective increases in IgG3 responses.				[5]
Porphyromonas gingivalis (CFB bacteria)			MIC01000
Description	The activity of proteolytic enzymes from Porphyromonas gingivalis could effect enzymolysis of human immunoglobulin G3(lgG3).				[2]
Saccharomyces cerevisiae (budding yeasts)			MIC01145
Description	IgG3 could be against Saccharomyces cerevisiae.				[6]
Salmonella sp. (enterobacteria)			MIC01149
Description	Salmonella was associated with IgG3 response.				[1]
Streptococcus sp. (firmicutes)			MIC01276
Description	The abundance of Streptococcaceae is associated with IgG3 response.				[3]

References
1	Gut Microbiota-Induced Immunoglobulin G Controls Systemic Infection by Symbiotic Bacteria and Pathogens.Immunity. 2016 Mar 15;44(3):647-658. doi: 10.1016/j.immuni.2016.02.006. Epub 2016 Mar 2.
2	Immunoglobulin-degrading enzymes in localized juvenile periodontitis.J Periodontal Res. 1992 May;27(3):176-83. doi: 10.1111/j.1600-0765.1992.tb01666.x.
3	IgGs containing - and -type light chains and of all subclasses (IgG1-IgG4) from the sera of patients with autoimmune diseases and viral and bacterial infections hydrolyze DNA.J Mol Recognit. 2012 Jul;25(7):383-92. doi: 10.1002/jmr.2185.
4	Are there any clinical indications for measuring IgG subclasses. Ann Clin Biochem. 2002 Jul;39(Pt 4):374-7. doi: 10.1258/000456302760042678.
5	Immunoglobulin G1 (IgG1) and IgG3 antibodies are markers of progressive disease in leprosy.Infect Immun. 1995 Feb;63(2):410-5. doi: 10.1128/IAI.63.2.410-415.1995.
6	Anti-food and anti-microbial IgG subclass antibodies in inflammatory bowel disease.Scand J Gastroenterol. 2016 Dec;51(12):1453-1461. doi: 10.1080/00365521.2016.1205130. Epub 2016 Jul 25.

If you find any error in data or bug in web service, please kindly report it to Dr. Tang and Dr. Mou.