Details of Microbe Species (MIC)

General Information of MIC (ID: MIC00837)
MIC Name Moraxella catarrhalis (gamma-proteobacteria)
MIC Synonyms Mikrokkokus catarrhalis
Body Site Nose
Lineage Kingdom: Bacteria
Phylum: Proteobacteria
Class: Gammaproteobacteria
Order: Pseudomonadales
Family: Moraxellaceae
Genus: Moraxella
Species: Moraxella catarrhalis
Oxygen Sensitivity Aerobe
Microbial Metabolism Respiratory
Gram Negative
Genome Size (bp) 1887974
No. of Coding Genes 1711
No. of Non-Coding Genes 62
No. of Small Non-Coding Genes 62
No. of Gene Transcripts 1773
No. of Base Pairs 1941566
Description Moraxella catarrhalis is an aerobic, Gram negative, nonmotile, oxidase-positive diplococcus that can cause infections of the respiratory system, middle ear, eye, central nervous system, and joints of humans. It causes the infection of the host cell by sticking to the host cell using trimeric autotransporter adhesins.
External Links Taxonomy ID
480
Genome Assembly ID
ASM74045v1
GOLD Organism ID
Go0000471
Disease Relevance
          Otitis media  [ICD-11: AA80]
             Description Moraxella catarrhalis is a human-adapted pathogen, and a major cause of otitis media. [1]
Host Genetic Factors (HGFs)
          DEFB103A
             HGF ID HGF2349 HGF Info       Class Copy Number Variation: Gene Deletion (CNV-GDe)
             Description The increased DEFB-CN has been significantly associated with the abundance of Moraxella catarrhali (p-value<0.05). [2]
          hsa-miR-328-5p
             HGF ID HGF0667 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The level of miR-328 expression could decrease the abundancce of Moraxella catarrhalis. [3]
          rs2275913
             HGF ID HGF1732 HGF Info       Class Single Nucleotide Polymorphism: Upstream variant (SNP-UV)
             Description The IL-17 SNP rs2275913 was connected with Moraxella catarrhalis detection in the hypopharynx. [4]
Host Immune Factors (HIFs)
          CEA cell adhesion molecule 1
             HIF ID HIFM0057 HIF Info       Class Checkpoint molecule (CM)
             Description CEACAM1 serves as a receptor for Moraxella catarrhalis pathogens in humans. [5]
          Interferon beta
             HIF ID HIFM0126 HIF Info       Class Cytokine (Cyt)
             Description Moraxella catarrhalis diminished the TLR3-dependent secretion of IFN-Beta through reducing enzyme activity. [6]
          Interferon lambda
             HIF ID HIFM0127 HIF Info       Class Cytokine (Cyt)
             Description Moraxella catarrhalis diminished the TLR3-dependent secretion of IFN through reducing enzyme activity. [6]
          Immunoglobulin M
             HIF ID HIFM0266 HIF Info       Class Immunoglobulin (Ig)
             Description The abundance of Moraxella catarrhalis is associated with IgM response. [7]
          Immunoglobulin G3
             HIF ID HIFM0267 HIF Info       Class Immunoglobulin (Ig)
             Description IgG3 is the predominant antibody response against Moraxella catarrhalis. [8]
          Immunoglobulin D
             HIF ID HIFM0277 HIF Info       Class Immunoglobulin (Ig)
             Description IgD has regulatory affinity which could bind to Neisseria catarrhalis. [9]
          Toll-like receptor 3
             HIF ID HIFM0218 HIF Info       Class Toll-like receptor (TLR)
             Description Moraxella catarrhalis decreases antiviral innate immune responses by down-regulation of TLR3 via inhibition of p53 in human bronchial epithelial cells. [6]
Environmental Factor(s)
             Disbiome ID
      579
References
1 Moraxella catarrhalis Restriction-Modification Systems Are Associated with Phylogenetic Lineage and Disease. Genome Biol Evol. 2018 Nov 1;10(11):2932-2946. doi: 10.1093/gbe/evy226.
2 Copy number variation of the beta defensin gene cluster on chromosome 8p influences the bacterial microbiota within the nasopharynx of otitis-prone children.PLoS One. 2014 May 27;9(5):e98269. doi: 10.1371/journal.pone.0098269. eCollection 2014.
3 Antagonism of miR-328 increases the antimicrobial function of macrophages and neutrophils and rapid clearance of non-typeable Haemophilus influenzae (NTHi) from infected lung. PLoS Pathog. 2015 Apr 20;11(4):e1004549. doi: 10.1371/journal.ppat.1004549. eCollection 2015 Apr.
4 The polymorphism of IL-17 G-152A was associated with childhood asthma and bacterial colonization of the hypopharynx in bronchiolitis.J Clin Immunol. 2010 Jul;30(4):539-45. doi: 10.1007/s10875-010-9391-8. Epub 2010 May 2.
5 CEACAM1 in Liver Injury, Metabolic and Immune Regulation.Int J Mol Sci. 2018 Oct 11;19(10):3110. doi: 10.3390/ijms19103110.
6 Moraxella catarrhalis decreases antiviral innate immune responses by down-regulation of TLR3 via inhibition of p53 in human bronchial epithelial cells. FASEB J. 2016 Jun;30(6):2426-34. doi: 10.1096/fj.201500172R. Epub 2016 Mar 15.
7 IRAK-4 and MyD88 deficiencies impair IgM responses against T-independent bacterial antigens.Blood. 2014 Dec 4;124(24):3561-71. doi: 10.1182/blood-2014-07-587824. Epub 2014 Oct 15.
8 Are there any clinical indications for measuring IgG subclasses. Ann Clin Biochem. 2002 Jul;39(Pt 4):374-7. doi: 10.1258/000456302760042678.
9 Many bacterial species bind human IgD.J Immunol. 1979 Apr;122(4):1468-72.

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