Details of Host Immune Factor (HIF) Regulating Microbe Species (MIC)

General Information of HIF (ID: HIFM0126)
HIF Name
Interferon beta
HIF Synonym(s)
interferon beta 1, IFNB1, IFB, IFF, IFNB
HIF Classification
Cytokine (Cyt)
Molecular Function
Cytokine
Description Interferon-beta (IFN-), acting via STAT1 and STAT2, is known to upregulate and downregulate a wide variety of genes, most of which are involved in the antiviral immune response. It is a member of Type I IFNs [1]
Pfam Interferon alpha/beta domain (PF00143 )
Pathway Chagas disease (American trypanosomiasis) (hsa05142 )
Cytokine-cytokine receptor interaction (hsa04060 )
Cytosolic DNA-sensing pathway (hsa04623 )
Epstein-Barr virus infection (hsa05169 )
Hepatitis B (hsa05161 )
Hepatitis C (hsa05160 )
Herpes simplex virus 1 infection (hsa05168 )
Human cytomegalovirus infection (hsa05163 )
Human immunodeficiency virus 1 infection (hsa05170 )
Human papillomavirus infection (hsa05165 )
Influenza A (hsa05164 )
JAK-STAT signaling pathway (hsa04630 )
Kaposi sarcoma-associated herpesvirus infection (hsa05167 )
Measles (hsa05162 )
NOD-like receptor signaling pathway (hsa04621 )
Natural killer cell mediated cytotoxicity (hsa04650 )
Necroptosis (hsa04217 )
Osteoclast differentiation (hsa04380 )
PI3K-Akt signaling pathway (hsa04151 )
RIG-I-like receptor signaling pathway (hsa04622 )
Shigellosis (hsa05131 )
TNF signaling pathway (hsa04668 )
Toll-like receptor signaling pathway (hsa04620 )
Tuberculosis (hsa05152 )
Yersinia infection (hsa05135 )
Sequence Click here to download the HIF sequence in FASTA format
External Links
Uniprot ID
IFNB_HUMAN
Microbe Species (MIC) Regulated by This HIF
         Bordetella pertussis (beta-proteobacteria) MIC00248
             Description A TLR2 agonist from Bordetella pertussis could synergistically induces production of IFN-beta through activiate the enzymatic activity. [2]
         Listeria monocytogenes (firmicutes) MIC00771
             Description The IFN-beta levels were lower with a weakened activation response to Listeria monocytogenes infection in Hdac6-deficient dendritic cells. [3]
         Moraxella catarrhalis (gamma-proteobacteria) MIC00837
             Description Moraxella catarrhalis diminished the TLR3-dependent secretion of IFN-Beta through reducing enzyme activity. [4]
         Spirochaetes (bacteria) MIC01204
             Description Oral Spirochaetes infection could occured through activiate the pathogenic factor IFN-Beta(enzymatic activity). [5]
References
1 Interferon Beta: From Molecular Level to Therapeutic Effects.Int Rev Cell Mol Biol. 2016;326:343-72. doi: 10.1016/bs.ircmb.2016.06.001. Epub 2016 Jul 20.
2 Sustained protective immunity against Bordetella pertussis nasal colonization by intranasal immunization with a vaccine-adjuvant combination that induces IL-17-secreting T(RM) cells. Mucosal Immunol. 2018 Nov;11(6):1763-1776. doi: 10.1038/s41385-018-0080-x. Epub 2018 Aug 20.
3 HDAC6 controls innate immune and autophagy responses to TLR-mediated signalling by the intracellular bacteria Listeria monocytogenes. PLoS Pathog. 2017 Dec 27;13(12):e1006799. doi: 10.1371/journal.ppat.1006799. eCollection 2017 Dec.
4 Moraxella catarrhalis decreases antiviral innate immune responses by down-regulation of TLR3 via inhibition of p53 in human bronchial epithelial cells. FASEB J. 2016 Jun;30(6):2426-34. doi: 10.1096/fj.201500172R. Epub 2016 Mar 15.
5 New insights into the emerging role of oral spirochaetes in periodontal disease. Clin Microbiol Infect. 2011 Apr;17(4):502-12. doi: 10.1111/j.1469-0691.2011.03460.x.

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