Details of Microbe Species (MIC)

General Information of MIC (ID: MIC00248)
MIC Name Bordetella pertussis (beta-proteobacteria)
MIC Synonyms Hemophilus pertussis
Body Site Lung
Lineage Kingdom: Bacteria
Phylum: Proteobacteria
Class: Betaproteobacteria
Order: Burkholderiales
Family: Alcaligenaceae
Genus: Bordetella
Species: Bordetella pertussis
Oxygen Sensitivity Aerobe
Microbial Metabolism Respiratory
Gram Negative
Host Relationship Pathogen
Genome Size (bp) 4105348
No. of Coding Genes 3554
No. of Non-Coding Genes 58
No. of Small Non-Coding Genes 58
No. of Gene Transcripts 3612
No. of Base Pairs 3662278
Description Bordetella pertussis is a Gram-negative, aerobic, pathogenic, encapsulated coccobacillus of the genus Bordetella, and the causative agent of pertussis or whooping cough.
External Links Taxonomy ID
520
Genome Assembly ID
6062_1_11
GOLD Organism ID
Go0525093
Host Genetic Factors (HGFs)
          hsa-miR-889-5p
             HGF ID HGF0699 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The hsa-miR-889-5p showed significant difference between Mycobacterium tuberculosis group and Bordetella pertussis group (p-value<0.05). [1]
          hsa-miR-576-3p
             HGF ID HGF0689 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The hsa-miR-576-3p showed significant difference between Mycobacterium tuberculosis group and Bordetella pertussis group (p-value<0.05). [1]
          hsa-miR-342-5p
             HGF ID HGF0668 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The hsa-miR-342-5p was significantly upregulated in pertussis patients with Bordetella pertussi infection (p-value<0.05). [2]
          hsa-miR-487b-5p
             HGF ID HGF0557 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The expression of hsa-miR-487b up-regulated by at least 1.5-fold in pertussis patients with Bordetella pertussis infection. [2]
          hsa-miR-202-3p
             HGF ID HGF0209 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The expression of hsa-miR-202 up-regulated by at least 1.5-fold in pertussis patients with Bordetella pertussis infection. [2]
          hsa-miR-361-5p
             HGF ID HGF0148 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The hsa-miR-361-5p showed significant difference between Mycobacterium tuberculosis group and Bordetella pertussis group (p-value<0.05). [1]
          hsa-miR-576-5p
             HGF ID HGF0103 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The expression of hsa-miR-576-5p upregulated by at least 1.5-fold in pertussis patients with Bordetella pertussi infection. [2]
Host Immune Factors (HIFs)
          Interferon beta
             HIF ID HIFM0126 HIF Info       Class Cytokine (Cyt)
             Description A TLR2 agonist from Bordetella pertussis could synergistically induces production of IFN-beta through activiate the enzymatic activity. [3]
          Interferon-12 subunit alpha
             HIF ID HIFM0130 HIF Info       Class Cytokine (Cyt)
             Description A TLR2 agonist from Bordetella pertussis could synergistically induces production of IL-12 through activiate the enzymatic activity. [3]
          Interleukin-23 subunit alpha
             HIF ID HIFM0144 HIF Info       Class Cytokine (Cyt)
             Description A TLR2 agonist from Bordetella pertussis could synergistically induces production of IL-23 through activiate the enzymatic activity. [3]
          Immunoglobulin alpha Fc receptor
             HIF ID HIFM0097 HIF Info       Class Fc Receptor (FCR)
             Description Enhanced in vitro uptake of Bordetella pertussis by neutrophils after targeting of FcRI(CD89) has been demonstrated. [4]
          CD4+ helper T cells
             HIF ID HIFC0068 HIF Info       Class T cells (TCs)
             Description Th1 response was promoted after parenteral immunization of mice with an experimental acellular pertussis vaccine formulated with LP-GMP, which conferred protection against lung infection with Bordetella pertussis. [3]
          CD4+ T cells
             HIF ID HIFC0069 HIF Info       Class T cells (TCs)
             Description Bordetella pertussis is associated with CD4 T cells responses. [3]
          T helper type 17 cells
             HIF ID HIFC0080 HIF Info       Class T cells (TCs)
             Description Th17 response was promoted after parenteral immunization of mice with an experimental acellular pertussis vaccine formulated with LP-GMP, which conferred protection against lung infection with Bordetella pertussis. [3]
References
1 DNA methylation silencing of microRNA gene methylator in the precancerous background mucosa with and without gastric cancer: Analysis of the effects of H. pylori eradication and long-term aspirin use. Watari J, Ito C, Shimoda T, Tomita T, Oshima T, Fukui H, Das KM, Miwa H.. Sci Rep. 2019 Aug 29;9(1):12559. doi: 10.1038/s41598-019-49069-1.
2 MicroRNA expression profile in RAW264.7 cells in response to Brucella melitensis infection. Zheng K, Chen DS, Wu YQ, Xu XJ, Zhang H, Chen CF, Chen HC, Liu ZF.. Int J Biol Sci. 2012;8(7):1013-22. doi: 10.7150/ijbs.3836. Epub 2012 Aug 3.
3 Sustained protective immunity against Bordetella pertussis nasal colonization by intranasal immunization with a vaccine-adjuvant combination that induces IL-17-secreting T(RM) cells. Mucosal Immunol. 2018 Nov;11(6):1763-1776. doi: 10.1038/s41385-018-0080-x. Epub 2018 Aug 20.
4 The human immunoglobulin A Fc receptor FcRI: a multifaceted regulator of mucosal immunity. Mucosal Immunol. 2011 Nov;4(6):612-24. doi: 10.1038/mi.2011.36. Epub 2011 Sep 21.

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