Details of Host Immune Factor (HIF) Regulating Microbe Species (MIC)

General Information of HIF (ID: HIFM0097)
HIF Name
Immunoglobulin alpha Fc receptor
HIF Synonym(s)
Fc fragment of IgA receptor, FCAR, FcalphaRI, CTB-61M7.2
HIF Classification
Fc Receptor (FCR)
Molecular Function
IgA-binding protein; Receptor
Description FcaRI also known as CD89, is a subtype of Fc Receptor. [1]
Pathway Phagosome (hsa04145 )
Staphylococcus aureus infection (hsa05150 )
Sequence Click here to download the HIF sequence in FASTA format
External Links
Uniprot ID
FCAR_HUMAN
Microbe Species (MIC) Regulated by This HIF
         Bordetella pertussis (beta-proteobacteria) MIC00248
             Description Enhanced in vitro uptake of Bordetella pertussis by neutrophils after targeting of FcRI(CD89) has been demonstrated. [2]
         Candida albicans (budding yeasts) MIC00317
             Description Enhanced in vitro uptake of Candida albicans by neutrophils after targeting of FcRI(CD89) has been demonstrated. [2]
         Escherichia coli (enterobacteria) MIC00516
             Description After targeting FcRI (CD89), neutrophils enhanced the effect of reducing Escherichia coli abundance. [2]
         Mycobacterium tuberculosis (actinobacteria) MIC00857
             Description It was recently shown that passive transfer of human IgA mAbs against Mycobacterium tuberculosis protected human FcRI(CD89) transgenic mice. [2]
         Neisseria meningitidis (beta-proteobacteria) MIC00891
             Description Enhanced in vitro uptake of Neisseria meningitidis by neutrophils after targeting of FcRI(CD89) has been demonstrated. [2]
         Porphyromonas gingivalis (CFB bacteria) MIC01000
             Description Enhanced in vitro uptake of Porphyromonas gingivalis by neutrophils after targeting of FcRI(CD89) has been demonstrated. [2]
         Staphylococcus aureus (firmicutes) MIC01208
             Description Staphylococcus aureus could produce several decoy proteins that obstruct binding of IgA to FcRI(CD89). [3]
         Streptococcus pyogenes (firmicutes) MIC01267
             Description Enhanced in vitro uptake of Streptococcus pneumonia by neutrophils after targeting of FcRI(CD89) has been demonstrated. [2]
References
1 The Fc receptor for IgA (FcalphaRI, CD89).Immunol Lett. 2004 Mar 29;92(1-2):23-31. doi: 10.1016/j.imlet.2003.11.018.
2 The human immunoglobulin A Fc receptor FcRI: a multifaceted regulator of mucosal immunity. Mucosal Immunol. 2011 Nov;4(6):612-24. doi: 10.1038/mi.2011.36. Epub 2011 Sep 21.
3 IgA and FcRI: Pathological Roles and Therapeutic Opportunities. Front Immunol. 2019 Mar 22;10:553. doi: 10.3389/fimmu.2019.00553. eCollection 2019.

If you find any error in data or bug in web service, please kindly report it to Dr. Tang and Dr. Mou.