Details of Microbe Species (MIC)

General Information of MIC (ID: MIC00857)
MIC Name Mycobacterium tuberculosis (actinobacteria)
MIC Synonyms Bacterium tuberculosis
Body Site Lung
Lineage Kingdom: Bacteria
Phylum: Actinobacteria
Class: Actinobacteria
Order: Corynebacteriales
Family: Mycobacteriaceae
Genus: Mycobacterium
Species: Mycobacterium tuberculosis
Oxygen Sensitivity Anaerobe
Microbial Metabolism fermentative
Gram Positive
Description Mycobacterium tuberculosis is highly aerobic and Gram-positive which exists in the respiratory system of high oxygen levels.
External Links Taxonomy ID
1773
Genome Assembly ID
7414_6_20
GOLD Organism ID
Go0006687
Disease Relevance
          Tuberculosis  [ICD-11: 1B10]
             Description Tuberculosis is a contagious, infectious disease, due to Mycobacterium tuberculosis. [1]
Host Genetic Factors (HGFs)
          hsa-miR-889-5p
             HGF ID HGF0699 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The microRNA-889 inhibits autophagy to maintain Mycobacterial survival in patients with latent tuberculosis infection by targeting TWEAK. [2]
          hsa-miR-576-3p
             HGF ID HGF0689 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The level of miR-576-3p expression showed significant upregulation in Mycobacterium tuberculosis infection (p-value<0.05). [3]
          hsa-miR-125a-3p
             HGF ID HGF0637 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The level of miR-125a expression inhibits autophagy activation and antimicrobial responses during Mycobacterial tuberculosis infection. [4]
          hsa-miR-125b-5p
             HGF ID HGF0278 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The level of miR-125b expression showed significantly upregulated in Mycobacterium tuberculosis infection (p-value<0.05). [5]
          hsa-miR-132-3p
             HGF ID HGF0267 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The level of miR-132 expression showed significantly upregulated in Mycobacterium tuberculosis infection (p-value<0.05). [5]
          hsa-miR-155-5p
             HGF ID HGF0243 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The level of miR-155 expression showed significantly downregulated in Mycobacterium tuberculosis infection (p-value<0.05). [5]
          hsa-miR-17-5p
             HGF ID HGF0239 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The miR-17-5p regulates autophagy in Mycobacterium tuberculosis infected macrophages. [6]
          hsa-miR-1178
             HGF ID HGF2378 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The miR-1178 regulates mycobacterial survival and inflammatory responses in Mycobacterium tuberculosis\infected macrophages. [7]
          hsa-miR-23a-5p
             HGF ID HGF0191 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The miR-23a-5p modulates mycobacterial survival and autophagy during mycobacterium tuberculosis infection. [8]
          hsa-miR-23b-3p
             HGF ID HGF0190 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The miR-23b-3p is a biomarkers for prognosis tuberculosis, which is a contagious lung disease caused by Mycobacterium tuberculosis. [9]
          hsa-miR-26a-5p
             HGF ID HGF0185 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The level of miR-26a expression showed significantly upregulated in Mycobacterium tuberculosis infection (p-value<0.05). [5]
          hsa-miR-27a-3p
             HGF ID HGF0182 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The miR-27a promotes intracellular survival during Mycobacterium tuberculosis infection. [10]
          hsa-miR-27b-3p
             HGF ID HGF0180 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The miR-27b modulates inflammatory response and apoptosis during Mycobacterium tuberculosis infection. [11]
          hsa-miR-32-5p
             HGF ID HGF0160 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The miR-32-5p regulates mycobacterial survival and inflammatory responses in Mycobacterium tuberculosis-infected macrophages. [12]
          hsa-miR-361-5p
             HGF ID HGF0148 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The level of miR-361-5p expression showed significant upregulation in Mycobacterium tuberculosis infection (p-value<0.05). [3]
          hsa-miR-99b-5p
             HGF ID HGF0081 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The level of miR-99b expression was significantly downregulated with Mycobacterium tuberculosis infection (p-value<0.05). [5]
          hsa-miR-144-5p
             HGF ID HGF2368 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The hsa-miR-144-5p inhibits antimicrobial responses against Mycobacterium tuberculosis in human monocytes and macrophages by targeting the autophagy protein DRAM2. [13]
          rs75839717
             HGF ID HGF2301 HGF Info       Class Single Nucleotide Polymorphism (SNP)
             Description The genotypes at chromosome 1 SNP rs75839717 was associated with Mycobacterium tuberculosis induced IL-9 levels (p-value<0.05). [14]
          rs74513903
             HGF ID HGF2009 HGF Info       Class Single Nucleotide Polymorphism (SNP)
             Description The genotypes at chromosome 7 SNP rs74513903 was associated with Mycobacterium tuberculosis induced IL-9 levels (p-value<0.05). [14]
          rs495198
             HGF ID HGF2292 HGF Info       Class Single Nucleotide Polymorphism (SNP)
             Description The rs495198 SNP was significantly associated with the abundance of Mycobacterium tuberculosis (p-value<0.005). [15]
          rs4290827
             HGF ID HGF2088 HGF Info       Class Single Nucleotide Polymorphism (SNP)
             Description The rs4290827 SNP was significantly associated with the abundance of Mycobacterium tuberculosis (p-value<0.005). [15]
          rs3979990
             HGF ID HGF1428 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs3979990 SNP was significantly associated with the abundance of Mycobacterium tuberculosis (p-value<0.005). [15]
          rs3127931
             HGF ID HGF2268 HGF Info       Class Single Nucleotide Polymorphism (SNP)
             Description The rs3127931 SNP was significantly associated with the abundance of Mycobacterium tuberculosis (p-value<0.005). [15]
          rs2745739
             HGF ID HGF1553 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs2745739 SNP was significantly associated with the abundance of Mycobacterium tuberculosis (p-value<0.005). [15]
          rs2673818
             HGF ID HGF2259 HGF Info       Class Single Nucleotide Polymorphism (SNP)
             Description The rs2673818 SNP was significantly associated with the abundance of Mycobacterium tuberculosis (p-value<0.005). [15]
          rs236512
             HGF ID HGF1698 HGF Info       Class Single Nucleotide Polymorphism: Upstream variant (SNP-UV)
             Description The rs236512 SNP was significantly associated with the abundance of Mycobacterium tuberculosis (p-value<0.005). [15]
          rs235681
             HGF ID HGF1461 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs235681 SNP was significantly associated with the abundance of Mycobacterium tuberculosis (p-value<0.005). [15]
          rs213281
             HGF ID HGF1639 HGF Info       Class Single Nucleotide Polymorphism: Upstream variant (SNP-UV)
             Description The rs213281 SNP was significantly associated with the abundance of Mycobacterium tuberculosis (p-value<0.005). [15]
          rs213147
             HGF ID HGF1296 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs213147 SNP was significantly associated with the abundance of Mycobacterium tuberculosis (p-value<0.005). [15]
          rs200379
             HGF ID HGF2150 HGF Info       Class Single Nucleotide Polymorphism (SNP)
             Description The rs200379 SNP was significantly associated with the abundance of Mycobacterium tuberculosis (p-value<0.005). [15]
          rs1955941
             HGF ID HGF1515 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs1955941 SNP was significantly associated with the abundance of Mycobacterium tuberculosis (p-value<0.005). [15]
          rs1877744
             HGF ID HGF2170 HGF Info       Class Single Nucleotide Polymorphism (SNP)
             Description The rs1877744 SNP was significantly associated with the abundance of Mycobacterium tuberculosis (p-value<0.005). [15]
          rs1875295
             HGF ID HGF1438 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs1875295 SNP was significantly associated with the abundance of Mycobacterium tuberculosis (p-value<0.005). [15]
          rs1722228
             HGF ID HGF2010 HGF Info       Class Single Nucleotide Polymorphism (SNP)
             Description The rs1722228 SNP was significantly associated with the abundance of Mycobacterium tuberculosis (p-value<0.005). [15]
          rs1152153
             HGF ID HGF2310 HGF Info       Class Single Nucleotide Polymorphism (SNP)
             Description The rs1152153 SNP was significantly associated with the abundance of Mycobacterium tuberculosis (p-value<0.005). [15]
          rs1361285
             HGF ID HGF1341 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs1361285 SNP was significantly associated with the abundance of Mycobacterium tuberculosis (p-value<0.005). [15]
          rs11141235
             HGF ID HGF1751 HGF Info       Class Single Nucleotide Polymorphism: Upstream variant (SNP-UV)
             Description The minor allele C at SNP rs11141235 was associated with Mycobacterium tuberculosis induced IL-6 production (p-value<0.05). [14]
          rs1038500
             HGF ID HGF1591 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs1038500 SNP was significantly associated with the abundance of Mycobacterium tuberculosis (p-value<0.005). [15]
Host Immune Factors (HIFs)
          Human beta-defensin 10
             HIF ID HIFM0091 HIF Info       Class Antimicrobial peptide (AMP)
             Description The hBD10 displayed slightly higher inhibitory activity toward the Mycobacterium tuberculosis MDR strain (MIC 5.9 M) than the Mycobacterium tuberculosis H37Rv strain(MIC 11.8 M). [16]
          Human granulysin
             HIF ID HIFM0108 HIF Info       Class Antimicrobial peptide (AMP)
             Description Granulysin-dependent has enzymatic activity to kill of intracellular and extracellular Mycobacterium tuberculosis by V9/V2 T lymphocytes. [17]
          T-cell surface glycoprotein CD1b
             HIF ID HIFM0039 HIF Info       Class Checkpoint molecule (CM)
             Description Nearly all known foreign antigens presented by CD1b, including mycolic acid, glucose monomycolate, are selectively synthesized by Mycobacterium tuberculosis and related mycobacterial species. [18]
          C-C motif chemokine 20
             HIF ID HIFM0023 HIF Info       Class Cytokine (Cyt)
             Description There is no difference in global expression of the production of the CCL20 protein in the lungs after Mycobacterium tuberculosis infection. [19]
          Interferon gamma
             HIF ID HIFM0260 HIF Info       Class Cytokine (Cyt)
             Description The importance of IFN-Gamma production by CD4+ cells is particularly relevant at the early stages of Mycobacterium tuberculosis infection. [20]
          Dendritic cells
             HIF ID HIFC0003 HIF Info       Class Dendritic cells (DCs)
             Description Relative abundances of Mycobacterium tuberculosis is associated with dendritic cells response. [20]
          BATF3+ dendritic cells
             HIF ID HIFC0167 HIF Info       Class Dendritic cells (DCs)
             Description Batf3+ dendritic cells induced IgA responses which showed clearance of Mycobacterium tuberculosis. [21]
          CD11b+ dendritic cells
             HIF ID HIFC0203 HIF Info       Class Dendritic cells (DCs)
             Description CD11b+ DCs are infected by Mycobacterium tuberculosis, leading to antigen presentation in lymph nodes and protective Th1 differentiation. [22]
          Immunoglobulin alpha Fc receptor
             HIF ID HIFM0097 HIF Info       Class Fc Receptor (FCR)
             Description It was recently shown that passive transfer of human IgA mAbs against Mycobacterium tuberculosis protected human FcRI(CD89) transgenic mice. [23]
          Neutrophils
             HIF ID HIFC0029 HIF Info       Class Granulocytes (Gra)
             Description Mycobacterium tuberculosis interfered with the functions of neutrophils. [20]
          Immunoglobulin G4
             HIF ID HIFM0278 HIF Info       Class Immunoglobulin (Ig)
             Description Mycobacterium tuberculosis may be associated with IgG4-related disease. [24]
          Bone marrow macrophages
             HIF ID HIFC0018 HIF Info       Class Macrophages (Mac)
             Description Bone marrow macrophages can protect against Mycobacterium tuberculosis infection. [25]
          Macrophages
             HIF ID HIFC0020 HIF Info       Class Macrophages (Mac)
             Description Macrophages are known to be the main host cell target for Mycobacterium tuberculosis. [19]
          Monocytes
             HIF ID HIFC0024 HIF Info       Class Monocytes (Mono)
             Description Recruitment of monocytes is essential for effective control and clearance of Mycobacterium tuberculosis. [26]
          CD14+ CD16 monocytes
             HIF ID HIFC0208 HIF Info       Class Monocytes (Mono)
             Description A longer infection time from Mycobacterium tuberculosis resulted in an increase of the abundance of CD14+CD16 monocytes infected. [27]
          CD56+ Natural Killer cells
             HIF ID HIFC0095 HIF Info       Class Natural killer cells (NKCs)
             Description The NKp44, of which the induction involved mainly CD56+ NK cells, was able to bind the Mycobacterium tuberculosis. [28]
          CD4+ T cells
             HIF ID HIFC0069 HIF Info       Class T cells (TCs)
             Description CD4+ T lymphocytes were traditionally considered the pillars of immune defense against Mycobacterium tuberculosis. [20]
          CD4+ regulatory T cells
             HIF ID HIFC0034 HIF Info       Class T cells (TCs)
             Description A subset of CD4+ T cells reactive to Mycobacterium tuberculosis could increase the production of the immunoregulatory cytokine IL10 of 7%(p<0.05). [29]
          Toll-like receptor 2
             HIF ID HIFM0217 HIF Info       Class Toll-like receptor (TLR)
             Description Mycobacterium tuberculosis was associated with TLR2 expression. [20]
Environmental Factor(s)
             Disbiome ID
      803
References
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