General Information of HIF (ID: HIFM0091)
HIF Name	Human beta-defensin 10
HIF Synonym(s)	hBD10, BNBD-10
HIF Classification	Antimicrobial peptide (AMP)
Molecular Function	Antibiotic; Antimicrobial; Defensin
Description	hBD10 has been identified in humans. It forms the first line of host defense against pathogenic infections and are a key component of the ancient innate immune system.				[1]
Sequence	Click here to download the HIF sequence in FASTA format
External Links
	Uniprot ID	DFB10_BOVIN
	APD ID	AP03101

Microbe Species (MIC) Regulated by This HIF
Escherichia coli (enterobacteria)			MIC00516
Description	The hBD10 inhibited the growth of Escherichia coli at the concentration of 25M for 6 hours.				[2]
Mycobacterium tuberculosis (actinobacteria)			MIC00857
Description	The hBD10 displayed slightly higher inhibitory activity toward the Mycobacterium tuberculosis MDR strain (MIC 5.9 M) than the Mycobacterium tuberculosis H37Rv strain(MIC 11.8 M).				[2]
Staphylococcus aureus (firmicutes)			MIC01208
Description	The hBD10 inhibited the growth of Staphylococcus aureus at the concentration of 100M for 12 hours.				[2]

References
1	APD3: the antimicrobial peptide database as a tool for research and education.Nucleic Acids Res. 2016 Jan 4;44(D1):D1087-93. doi: 10.1093/nar/gkv1278. Epub 2015 Nov 23.
2	Antimicrobial activity and structure of a consensus human -defensin and its comparison to a novel putative hBD10.Proteins. 2020 Jan;88(1):175-186. doi: 10.1002/prot.25785. Epub 2019 Jul 30.

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