General Information of HIF (ID: HIFM0039)
HIF Name	T-cell surface glycoprotein CD1b
HIF Synonym(s)	CD1b, CD1B
HIF Classification	Checkpoint molecule (CM)
Description	CD1 molecules (CD1b in human) enables presentation of foreign microbial lipids for specific T cell recognition.				[1]
Pfam	Immunoglobulin C1-set domain (PF07654 )
	MHC-I family domain (PF16497 )
Pathway	Amoebiasis (hsa05146 )
	Hematopoietic cell lineage (hsa04640 )
	Tight junction (hsa04530 )
Sequence	Click here to download the HIF sequence in FASTA format
External Links
	Uniprot ID	CD1B_HUMAN

Microbe Species (MIC) Regulated by This HIF
Corynebacterium glutamicum (actinobacteria)			MIC00455
Description	CD1b dextramers loaded with either pure synthetic PGs matching the common mammalian form Corynebacterium glutamicum.				[2]
Escherichia coli (enterobacteria)			MIC00516
Description	CD1b dextramers loaded with natural PG from Escherichia coli.				[2]
Listeria monocytogenes (firmicutes)			MIC00771
Description	CD1b dextramers loaded with natural PG from Listeria monocytogenes.				[2]
Mycobacterium tuberculosis (actinobacteria)			MIC00857
Description	Nearly all known foreign antigens presented by CD1b, including mycolic acid, glucose monomycolate, are selectively synthesized by Mycobacterium tuberculosis and related mycobacterial species.				[2]
Salmonella sp. (enterobacteria)			MIC01149
Description	The CD1b-mediated T cells response was associated with the abundance of pathogenic Salmonella.				[2]
Staphylococcus aureus (firmicutes)			MIC01208
Description	The Staphylococcus aureus was associated with the expression of CD1b proteins.				[2]

References
1	CD1-dependent dendritic cell instruction.Nat Immunol. 2002 Dec;3(12):1163-8. doi: 10.1038/ni851. Epub 2002 Nov 4.
2	Human autoreactive T cells recognize CD1b and phospholipids.Proc Natl Acad Sci U S A. 2016 Jan 12;113(2):380-5. doi: 10.1073/pnas.1520947112. Epub 2015 Nov 30.

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