Details of Host Immune Factor (HIF) Regulating Microbe Species (MIC)

General Information of HIF (ID: HIFM0023)
HIF Name
C-C motif chemokine 20
HIF Synonym(s)
C-C motif chemokine ligand 20, CKb4, Exodus, LARC, MIP-3-alpha, MIP-3a, MIP3A, SCYA20, ST38
HIF Classification
Cytokine (Cyt)
Molecular Function
Antibiotic; Antimicrobial; Cytokine
Description Chemokines were originally described as cytokines that mediate leukocyte recruitment to sites of inflammation [1]
Pfam Small cytokines (intecrine/chemokine), interleukin-8 like (PF00048 )
Pathway Chemokine signaling pathway (hsa04062 )
Cytokine-cytokine receptor interaction (hsa04060 )
IL-17 signaling pathway (hsa04657 )
Rheumatoid arthritis (hsa05323 )
TNF signaling pathway (hsa04668 )
Viral protein interaction with cytokine and cytokine receptor (hsa04061 )
Sequence Click here to download the HIF sequence in FASTA format
External Links
Uniprot ID
CCL20_HUMAN
Microbe Species (MIC) Regulated by This HIF
         Bifidobacterium longum subsp. infantis (actinobacteria) MIC00215
             Description Bifidobacterium infantis could-dependently inhibited the secretion of CCL20 by IECs. [2]
         Candida albicans (budding yeasts) MIC00317
             Description CCL20 has a property conferring a direct antimicrobial enzymatic activity against Candida albicans. [2]
         Clostridioides difficile (firmicutes) MIC00396
             Description The CCL20 secretion by IECs after infection by Clostridium difficile was shown to be negatively modulated by preincubation with commensal bacteria. [2]
         Escherichia coli (enterobacteria) MIC00516
             Description CCL20 has a property conferring a direct antimicrobial enzymatic activity against Escherichia coli. [2]
         Listeria monocytogenes (firmicutes) MIC00771
             Description During intestinal infection by Listeria monocytogenes, the production of CCL20 was increased. [2]
         Mycobacterium tuberculosis (actinobacteria) MIC00857
             Description There is no difference in global expression of the production of the CCL20 protein in the lungs after Mycobacterium tuberculosis infection. [3]
         Prevotella bivia (CFB bacteria) MIC01007
             Description Prevotella bivia could induce higher level expression of CCL20. [4]
         Prevotella nanceiensis (CFB bacteria) MIC01018
             Description Prevotella nanceiensis can increased levels of CCL20 expression to induce severe lung neutrophilia in mice. [4]
         Salmonella enterica subsp. enterica (enterobacteria) MIC01154
             Description The CCL20 secretion by IECs after infection by Salmonella typhimurium was shown to be negatively modulated by preincubation with commensal bacteria. [2]
         Shigella flexneri (enterobacteria) MIC01182
             Description Shigella flexneri is able to downregulate the CCL20 response. [2]
         Staphylococcus aureus (firmicutes) MIC01208
             Description CCL20 has a property conferring a direct antimicrobial enzymatic activity against Staphylococcus aureus. [2]
         Yersinia enterocolitica (enterobacteria) MIC01398
             Description The CCL20 expresssion has been observed during infection by Yersinia enterocolitica. [2]
References
1 CCL20 Signaling in the Tumor Microenvironment.Adv Exp Med Biol. 2020;1231:53-65. doi: 10.1007/978-3-030-36667-4_6.
2 CCL20 Displays Antimicrobial Activity Against Cryptosporidium parvum, but Its Expression Is Reduced During Infection in the Intestine of Neonatal Mice.J Infect Dis. 2015 Oct 15;212(8):1332-40. doi: 10.1093/infdis/jiv206. Epub 2015 Apr 2.
3 The Host Microbiota Contributes to Early Protection Against Lung Colonization by Mycobacterium tuberculosis.Front Immunol. 2018 Nov 14;9:2656. doi: 10.3389/fimmu.2018.02656. eCollection 2018.
4 The immune response to Prevotella bacteria in chronic inflammatory disease. Immunology. 2017 Aug;151(4):363-374. doi: 10.1111/imm.12760. Epub 2017 Jun 20.

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