Details of Microbe Species (MIC)

General Information of MIC (ID: MIC01182)
MIC Name Shigella flexneri (enterobacteria)
MIC Synonyms Shigella paradysenteriae
Body Site Gut
Lineage Kingdom: Bacteria
Phylum: Proteobacteria
Class: Gammaproteobacteria
Order: Enterobacterales
Family: Enterobacteriaceae
Genus: Shigella
Species: Shigella flexneri
Oxygen Sensitivity Facultative anaerobe
Microbial Metabolism Fermentative; Respiratory
Gram Negative
Genome Size (bp) 4526576
No. of Coding Genes 4725
No. of Non-Coding Genes 107
No. of Small Non-Coding Genes 107
No. of Gene Transcripts 4832
No. of Base Pairs 4513854
Description Shigella flexneri is a species of facultative anaerobic, Gram negative bacteria in the genus Shigella that can cause diarrhea in humans. S. flexneri infections can usually be treated with antibiotics, although some strains have become resistant.
External Links Taxonomy ID
623
Genome Assembly ID
ASM719759v1
GOLD Organism ID
Go0004266
Disease Relevance
          Irritable bowel syndrome  [ICD-11: DD91]
             Description Diarrhea caused by Shigella flexneri in patients with primary HIV infection. [1]
Host Genetic Factors (HGFs)
          hsa-miR-29b-2-5p
             HGF ID HGF0176 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The level of miR-29b-2-5p expression showed decreased upon Shigella flexneri infection. [2]
Host Immune Factors (HIFs)
          IgA plasma B cell
             HIF ID HIFC0221 HIF Info       Class B cells (BCs)
             Description IgA plasma cell response was associated with the condition of Shigella flexneri infection. [3]
          C-C motif chemokine 20
             HIF ID HIFM0023 HIF Info       Class Cytokine (Cyt)
             Description Shigella flexneri is able to downregulate the CCL20 response. [4]
          Immunoglobulin M
             HIF ID HIFM0266 HIF Info       Class Immunoglobulin (Ig)
             Description Secretory IgM could prevent Shigella flexneri-induced intestine epithelial cell damage in an in vitro cell model. [5]
          Immunoglobulin A
             HIF ID HIFM0272 HIF Info       Class Immunoglobulin (Ig)
             Description Secretory IgA showed could Shigella flexneri-induced intestine epithelial cell damage in an in vitro cell model. [5]
Environmental Factor(s)
             Disbiome ID
      267
             gutMDisorder ID
      gm0603
References
1 Diarrhea caused by Shigella flexneri in patients with primary HIV infection. Int J STD AIDS. 2019 Jul;30(8):814-816. doi: 10.1177/0956462418813060. Epub 2019 May 2.
2 MicroRNA-889 Inhibits Autophagy To Maintain Mycobacterial Survival in Patients with Latent Tuberculosis Infection by Targeting TWEAK. Chen DY, Chen YM, Lin CF, Lo CM, Liu HJ, Liao TL.. mBio. 2020 Jan 28;11(1):e03045-19. doi: 10.1128/mBio.03045-19.
3 Safety and immunogenicity of an intranasal Shigella flexneri 2a Invaplex 50 vaccine.Vaccine. 2011 Sep 16;29(40):7009-19. doi: 10.1016/j.vaccine.2011.07.033. Epub 2011 Jul 23.
4 CCL20 Displays Antimicrobial Activity Against Cryptosporidium parvum, but Its Expression Is Reduced During Infection in the Intestine of Neonatal Mice.J Infect Dis. 2015 Oct 15;212(8):1332-40. doi: 10.1093/infdis/jiv206. Epub 2015 Apr 2.
5 Limited Innovations After More Than 65 Years of Immunoglobulin Replacement Therapy: Potential of IgA- and IgM-Enriched Formulations to Prevent Bacterial Respiratory Tract Infections.Front Immunol. 2018 Aug 23;9:1925. doi: 10.3389/fimmu.2018.01925. eCollection 2018.

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