General Information of HIF (ID: HIFC0221)
HIF Name	IgA plasma B cell
HIF Synonym(s)	IgA plasma cell
HIF Classification	B cells (BCs)
Description	IgA plasma cell is a type of the immune cells.				[1]

Microbe Species (MIC) Regulated by This HIF
Campylobacter jejuni (epsilon-proteobacteria)			MIC00307
Description	IgA plasma cell responsed to the expression of Campylobacter jejuni infection.				[2]
Citrobacter rodentium (enterobacteria)			MIC00366
Description	The number of IgA plasma cell quickly accumulated in the cecum/colon in responses to Citrobacter rodentium				[3]
Enterovirus C (viruses)			MIC02010
Description	The expression of Poliovirus vaccine could elicited blood IgA plasma cell responses.				[4]
Escherichia coli (enterobacteria)			MIC00516
Description	The expression of Enterotoxigenic Escherichia coli (ETEC) vaccine exhibited positive IgA plasma cell responses.				[5]
Leishmania infantum (kinetoplastids)			MIC01797
Description	The number of IgA plasma cell were rare in the spleens of Visceral leishmaniasis caused by Leishmania infantum.				[6]
Salmonella enterica subsp. enterica (enterobacteria)			MIC01154
Description	IgA plasma cell could recognized the expression of Salmonella Typhi lipopolysaccharide.				[7]
Salmonella sp. (enterobacteria)			MIC01149
Description	IgA plasma cell response was associated with the condition of Salmonella infection.				[3]
Shigella dysenteriae (enterobacteria)			MIC01181
Description	Live Shigella dysenteriae 1 strains elicited a significant circulating IgA plasma cell expression.				[8]
Shigella flexneri (enterobacteria)			MIC01182
Description	IgA plasma cell response was associated with the condition of Shigella flexneri infection.				[9]
Vibrio cholerae (gamma-proteobacteria)			MIC01369
Description	Anti-OSP(O-specific polysaccharide) IgA plasma cell responses significantly happened following the first vaccination against killed Vibrio cholerae O1 and O139 organisms.				[10]

References
1	A Protocol for the Comprehensive Flow Cytometric Analysis of Immune Cells in Normal and Inflamed Murine Non-Lymphoid Tissues.PLoS One. 2016 Mar 3;11(3):e0150606. doi: 10.1371/journal.pone.0150606. eCollection 2016.
2	Assessment of the duration of protection in Campylobacter jejuni experimental infection in humans.Infect Immun. 2010 Apr;78(4):1750-9. doi: 10.1128/IAI.01021-09. Epub 2010 Jan 19.
3	Re-thinking the functions of IgA(+) plasma cells.Gut Microbes. 2014;5(5):652-62. doi: 10.4161/19490976.2014.969977.
4	Human Circulating Antibody-Producing B Cell as a Predictive Measure of Mucosal Immunity to Poliovirus.PLoS One. 2016 Jan 5;11(1):e0146010. doi: 10.1371/journal.pone.0146010. eCollection 2016.
5	Safety and immunogenicity of a single oral dose of recombinant double mutant heat-labile toxin derived from enterotoxigenic Escherichia coli.Clin Vaccine Immunol. 2013 Nov;20(11):1764-70. doi: 10.1128/CVI.00464-13. Epub 2013 Sep 18.
6	Disruption of Splenic Lymphoid Tissue and Plasmacytosis in Canine Visceral Leishmaniasis: Changes in Homing and Survival of Plasma Cells.PLoS One. 2016 May 31;11(5):e0156733. doi: 10.1371/journal.pone.0156733. eCollection 2016.
7	Live oral typhoid vaccine Ty21a induces cross-reactive humoral immune responses against Salmonella enterica serovar Paratyphi A and S. Paratyphi B in humans.Clin Vaccine Immunol. 2012 Jun;19(6):825-34. doi: 10.1128/CVI.00058-12. Epub 2012 Apr 4.
8	Safety and immunogenicity of SC599, an oral live attenuated Shigella dysenteriae type-1 vaccine in healthy volunteers: results of a Phase 2, randomized, double-blind placebo-controlled trial.Vaccine. 2009 Feb 18;27(8):1184-91. doi: 10.1016/j.vaccine.2008.12.021. Epub 2009 Jan 9.
9	Safety and immunogenicity of an intranasal Shigella flexneri 2a Invaplex 50 vaccine.Vaccine. 2011 Sep 16;29(40):7009-19. doi: 10.1016/j.vaccine.2011.07.033. Epub 2011 Jul 23.
10	Immune responses to O-specific polysaccharide and lipopolysaccharide of Vibrio cholerae O1 Ogawa in adult Bangladeshi recipients of an oral killed cholera vaccine and comparison to responses in patients with cholera.Am J Trop Med Hyg. 2014 May;90(5):873-81. doi: 10.4269/ajtmh.13-0498. Epub 2014 Mar 31.

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