| General Information of MIC (ID: MIC01797) |
| MIC Name |
Leishmania infantum (kinetoplastids)
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| MIC Synonyms |
Leishmania (Leishmania) infantum
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| Body Site |
Blood
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| Lineage |
Kingdom: Eukaryota
Phylum: Euglenozoa
Class: Kinetoplastea
Order: Trypanosomatida
Family: Trypanosomatidae
Genus: Leishmania
Species: Leishmania infantum
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| Description |
Leishmania infantum is the causative agent of infantile visceral leishmaniasis. It is also an unusual cause of cutaneous leishmaniasis, which is normally caused by specific lineages.
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| External Links |
Taxonomy ID |
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| Genome Assembly ID |
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| GOLD Organism ID |
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| Host Immune Factors (HIFs) |
| IgG plasma B cell |
| HIF ID |
HIFC0219 |
HIF Info
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Class |
B cells (BCs) |
| Description |
IgG plasma cell were the predominant plasma cells present in the spleens of Visceral leishmaniasis caused by Leishmania infantum. |
[1] |
| IgM plasma B cell |
| HIF ID |
HIFC0220 |
HIF Info
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Class |
B cells (BCs) |
| Description |
IgM plasma cells were present in the marginal zones and periarteriolar areas in the spleens of Visceral leishmaniasis caused by Leishmania infantum. |
[1] |
| IgA plasma B cell |
| HIF ID |
HIFC0221 |
HIF Info
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Class |
B cells (BCs) |
| Description |
The number of IgA plasma cell were rare in the spleens of Visceral leishmaniasis caused by Leishmania infantum. |
[1] |
| Immunoglobulin D |
| HIF ID |
HIFM0277 |
HIF Info
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Class |
Immunoglobulin (Ig) |
| Description |
IgD significantly increased on the surface of B cells during visceral leishmaniasis caused by Leishmania infantum. |
[2] |
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| References |
| 1 |
Disruption of Splenic Lymphoid Tissue and Plasmacytosis in Canine Visceral Leishmaniasis: Changes in Homing and Survival of Plasma Cells.PLoS One. 2016 May 31;11(5):e0156733. doi: 10.1371/journal.pone.0156733. eCollection 2016.
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| 2 |
Regulatory IgDhi B Cells Suppress T Cell Function via IL-10 and PD-L1 during Progressive Visceral Leishmaniasis.J Immunol. 2016 May 15;196(10):4100-9. doi: 10.4049/jimmunol.1502678. Epub 2016 Apr 13.
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