Details of Microbe Species (MIC)

General Information of MIC (ID: MIC00307)
MIC Name Campylobacter jejuni (epsilon-proteobacteria)
MIC Synonyms Vibrio jejuni
Body Site Gut
Lineage Kingdom: Bacteria
Phylum: Proteobacteria
Class: Epsilonproteobacteria
Order: Campylobacterales
Family: Campylobacteraceae
Genus: Campylobacter
Species: Campylobacter jejuni
Oxygen Sensitivity Microaerophile; Anaerobe
Microbial Metabolism Strictly respiratory
Gram Negative
Host Relationship Pathogen
Genome Size (bp) 1651321
No. of Coding Genes 1741
No. of Non-Coding Genes 39
No. of Small Non-Coding Genes 39
No. of Gene Transcripts 1780
No. of Base Pairs 1651321
Description Campylobacter jejuni is one of the most common causes of food poisoning in Europe and in the United States.
External Links Taxonomy ID
197
Genome Assembly ID
CJJ5070
GOLD Organism ID
Go0526175
Disease Relevance
          Guillain Barr Syndrome  [ICD-11: 8C01]
             Description Campylobacter jejuni was associated with guillain barr syndrome. [1]
          Inflammatory bowel disease  [ICD-11: DD72]
             Description Campylobacter jejuni was associated with inflammatory bowel disease. [1]
Host Immune Factors (HIFs)
          IgA plasma B cell
             HIF ID HIFC0221 HIF Info       Class B cells (BCs)
             Description IgA plasma cell responsed to the expression of Campylobacter jejuni infection. [2]
          Tumor necrosis factor ligand superfamily member 15
             HIF ID HIFM0224 HIF Info       Class Checkpoint molecule (CM)
             Description The Campylobacter jejuni could activate TL1A expression in human APC, including monocytes and monocyte-derived DC. [3]
          C-C motif chemokine 2
             HIF ID HIFM0022 HIF Info       Class Cytokine (Cyt)
             Description Campylobacter jejuni is associated with the MCP-1 expression. [4]
          Interferon-6
             HIF ID HIFM0151 HIF Info       Class Cytokine (Cyt)
             Description Campylobacter jejuni infection resulted in elevated colonic IL-6 secretion. [4]
          Tumor necrosis factor
             HIF ID HIFM0226 HIF Info       Class Cytokine (Cyt)
             Description Campylobacter jejuni infection with either strain resulted in elevated colonic IL-6, TNF and IFN-Gamma secretion. [4]
          Interferon gamma
             HIF ID HIFM0260 HIF Info       Class Cytokine (Cyt)
             Description Campylobacter jejuni infection with either strain resulted in elevated colonic IL-6, TNF and IFN-Gamma secretion. [4]
          Immunoglobulin M
             HIF ID HIFM0266 HIF Info       Class Immunoglobulin (Ig)
             Description IgM can significantly increase the killing of the enzymatic activity of Campylobacter jejuni. [5]
          Immunoglobulin G1
             HIF ID HIFM0269 HIF Info       Class Immunoglobulin (Ig)
             Description Campylobacter jejuni infection induced production of IgG1 autoantibodies against ganglioside GM1 and caused complement-mediated motor nerve injury. [6]
          Immunoglobulin G
             HIF ID HIFM0270 HIF Info       Class Immunoglobulin (Ig)
             Description Campylobacter jejuni ninfection induced production of IgG autoantibodies against ganglioside GM1 and caused complement-mediated motor nerve injury. [6]
Environmental Factor(s)
             Disbiome ID
      1258
             gutMDisorder ID
      gm0142
             aBiofilm Organism
      Campylobacter jejuni
References
1 Effects of antibiotic resistance (AR) and microbiota shifts on Campylobacter jejuni-mediated diseases. Anim Health Res Rev. 2017 Dec;18(2):99-111. doi: 10.1017/S1466252318000014.
2 Assessment of the duration of protection in Campylobacter jejuni experimental infection in humans.Infect Immun. 2010 Apr;78(4):1750-9. doi: 10.1128/IAI.01021-09. Epub 2010 Jan 19.
3 Microbial induction of inflammatory bowel disease associated gene TL1A (TNFSF15) in antigen presenting cells.Eur J Immunol. 2009 Nov;39(11):3239-50. doi: 10.1002/eji.200839087.
4 Protease Activity of Campylobacter jejuni HtrA Modulates Distinct Intestinal and Systemic Immune Responses in Infected Secondary Abiotic IL-10 Deficient Mice. Front Cell Infect Microbiol. 2019 Mar 29;9:79. doi: 10.3389/fcimb.2019.00079. eCollection 2019.
5 Limited Innovations After More Than 65 Years of Immunoglobulin Replacement Therapy: Potential of IgA- and IgM-Enriched Formulations to Prevent Bacterial Respiratory Tract Infections.Front Immunol. 2018 Aug 23;9:1925. doi: 10.3389/fimmu.2018.01925. eCollection 2018.
6 On-Membrane Dynamic Interplay between Anti-GM1 IgG Antibodies and Complement Component C1q.Int J Mol Sci. 2019 Dec 24;21(1):147. doi: 10.3390/ijms21010147.

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