Details of Host Immune Factor (HIF) Regulating Microbe Species (MIC)

General Information of HIF (ID: HIFM0224)
HIF Name
Tumor necrosis factor ligand superfamily member 15
HIF Synonym(s)
TL1, VEGI-251, VEGI, TNF ligand-related molecule 1, Vascular endothelial cell growth inhibitor, TL1A
HIF Classification
Checkpoint molecule (CM)
Molecular Function
Cytokine
Description TL1A is a transmembrane protein belonging to the TNF superfamily.It is a candidate cytokine for mediating inflammatory effects downstream of innate immune stimuli in RA. [1]
Pfam TNF(Tumour Necrosis Factor) family (PF00229 )
Pathway Cytokine-cytokine receptor interaction (hsa04060 )
Sequence Click here to download the HIF sequence in FASTA format
External Links
Uniprot ID
TNF15_HUMAN
Microbe Species (MIC) Regulated by This HIF
         Bacteroides thetaiotaomicron (CFB bacteria) MIC00179
             Description The Bacteroides thetaiotaomicron could activate TL1A expression in human APC, including monocytes and monocyte-derived DC. [2]
         Bacteroidetes (CFB bacteria) MIC00141
             Description The deletion of TL1A could change the ratio of Bacteroidetes. [3]
         Bifidobacterium breve (actinobacteria) MIC00210
             Description The Bifidobacterium breve could activate TL1A expression in human APC, including monocytes and monocyte-derived DC. [2]
         Campylobacter jejuni (epsilon-proteobacteria) MIC00307
             Description The Campylobacter jejuni could activate TL1A expression in human APC, including monocytes and monocyte-derived DC. [2]
         Clostridium sp. (firmicutes) MIC00418
             Description Clostridium was associated with TL1A. [4]
         Escherichia coli (enterobacteria) MIC00516
             Description The p38 MAPK inhibitors significantly reduced Escherichia coli induced TL1A mRNA in both monocytes (p-value<0.001). [2]
         Lactobacillus sp. (firmicutes) MIC00701
             Description The deletion of TL1A could reduce the abundance of Lactobacillus. [3]
         Listeria monocytogenes (firmicutes) MIC00771
             Description Listeria monocytogenes could activate TL1A expression in human APC, including monocytes and monocyte-derived DC. [2]
         Salmonella enterica subsp. enterica (enterobacteria) MIC01154
             Description The Salmonella typhimurium could activate TL1A expression in human APC, including monocytes and monocyte-derived DC. [2]
         Staphylococcus epidermidis (firmicutes) MIC01214
             Description The Staphylococcus epidermidis could activate TL1A expression in human APC, including monocytes and monocyte-derived DC. [2]
References
1 Circulating TNF-like protein 1A (TL1A) is elevated early in rheumatoid arthritis and depends on TNF.Arthritis Res Ther. 2020 May 7;22(1):106. doi: 10.1186/s13075-020-02198-9.
2 Microbial induction of inflammatory bowel disease associated gene TL1A (TNFSF15) in antigen presenting cells.Eur J Immunol. 2009 Nov;39(11):3239-50. doi: 10.1002/eji.200839087.
3 TL1A regulates TCR+ intraepithelial lymphocytes and gut microbial composition.Eur J Immunol. 2015 Mar;45(3):865-75. doi: 10.1002/eji.201444528. Epub 2014 Dec 23.
4 TL1A (TNFSF15) and DR3 (TNFRSF25): A Co-stimulatory System of Cytokines With Diverse Functions in Gut Mucosal Immunity.Front Immunol. 2019 Mar 27;10:583. doi: 10.3389/fimmu.2019.00583. eCollection 2019.

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