Details of Microbe Species (MIC)

General Information of MIC (ID: MIC01398)
MIC Name Yersinia enterocolitica (enterobacteria)
MIC Synonyms Bacterium enterocoliticum
Body Site Gut
Lineage Kingdom: Bacteria
Phylum: Proteobacteria
Class: Gammaproteobacteria
Order: Enterobacterales
Family: Yersiniaceae
Genus: Yersinia
Species: Yersinia enterocolitica
Oxygen Sensitivity Facultative anaerobe
Microbial Metabolism Fermentative; Respiratory
Gram Negative
Genome Size (bp) 4651078
No. of Coding Genes 4217
No. of Non-Coding Genes 98
No. of Small Non-Coding Genes 98
No. of Gene Transcripts 4315
No. of Base Pairs 4645698
Description Yersinia enterocolitica is a facultative anaerobic, Gram-negative, rod-shaped bacterium. It belongs to the Enterobacteriaceae family. Yersinia enterocolitica triggers intestinal and extraintestinal yersiniosis, involving a broad spectrum of symptoms, e.g. enteritis or lymphadenitis. It causes a broad range of gastrointestinal syndromes ranging from acute enteritis and enterocolitis to mesenteric lymphadenitis.
External Links Taxonomy ID
630
Genome Assembly ID
ASM170859v1
GOLD Organism ID
Go0000235
Disease Relevance
          Crohn disease  [ICD-11: DD70]
             Description Yersinia enterocolitica was associated with crohns disease. [1]
          Intestinal Yersiniosis  [ICD-11: 1A05]
             Description Yersinia enterocolitica causes the disease yersiniosis, which is an animal-borne disease occurring in humans, as well as in a wide array of animals such as cattle, deer, pigs, and birds. [2]
          Lymphadenitis  [ICD-11: BD90]
             Description Yersinia enterocolitica can cause Yersinia enterocolitica. [3]
          Vibrio mimicus gastroenteritis  [ICD-11: 1A40]
             Description Yersinia enterocolitica can cause gastroenteritis. [4]
Host Immune Factors (HIFs)
          Melanocyte-stimulating hormone alpha
             HIF ID HIFM0064 HIF Info       Class Antimicrobial peptide (AMP)
             Description Yersinia enerocolitica should able to stimulate production of Alpha-MSH crossreactive auto-Abs. [5]
          Beta-casein 213
             HIF ID HIFM0317 HIF Info       Class Antimicrobial peptide (AMP)
             Description PDC213 is identified by the group exhibited potent antimicrobial activity againstStaphylococcus aureus and Yersinia enterocolitica using in vitro assays. [6]
          B cells
             HIF ID HIFC0001 HIF Info       Class B cells (BCs)
             Description B cells hyperplasia had increased susceptibility to oral challenge with Yersinia enterocolitica. [7]
          C-C motif chemokine 20
             HIF ID HIFM0023 HIF Info       Class Cytokine (Cyt)
             Description The CCL20 expresssion has been observed during infection by Yersinia enterocolitica. [8]
          Interferon-6
             HIF ID HIFM0151 HIF Info       Class Cytokine (Cyt)
             Description Yersinia enterocolitica is associated with IL-6 expression. [9]
          Tumor necrosis factor
             HIF ID HIFM0226 HIF Info       Class Cytokine (Cyt)
             Description Yersinia enterocolitica could suppress of TNF-alpha production. [9]
          Interleukin-1
             HIF ID HIFM0263 HIF Info       Class Cytokine (Cyt)
             Description The abundance of Yersinia enterocolitica is associated with IL-1. [9]
          Macrophages
             HIF ID HIFC0020 HIF Info       Class Macrophages (Mac)
             Description The culture supernatant of plasmid-bearing Yersinia enterocolitica induced suppression of TNF-alpha mRNA expression in macrophage. [9]
Environmental Factor(s)
             Disbiome ID
      1091
             aBiofilm Organism
      Yersinia enterocolitica
References
1 Prevalence of Yersinia Species in the Ileum of Crohn's Disease Patients and Controls. Front Cell Infect Microbiol. 2018 Sep 21;8:336. doi: 10.3389/fcimb.2018.00336. eCollection 2018.
2 Mouse Models of Yersiniosis. Methods Mol Biol. 2019;2010:41-53. doi: 10.1007/978-1-4939-9541-7_4.
3 Mesenteric lymphadenitis caused by Yersinia enterocolitica. Prz Gastroenterol. 2015;10(2):118-21. doi: 10.5114/pg.2014.47504. Epub 2015 Jan 14.
4 Unraveling neutrophil-Yersinia interactions during tissue infection. F1000Res. 2019 Jul 11;8:F1000 Faculty Rev-1046. doi: 10.12688/f1000research.18940.1. eCollection 2019.
5 Bacterial ClpB heat-shock protein, an antigen-mimetic of the anorexigenic peptide -MSH, at the origin of eating disorders.Transl Psychiatry. 2014 Oct 7;4(10):e458. doi: 10.1038/tp.2014.98.
6 Not Avaliable
7 Modulation of immune development and function by intestinal microbiota.Trends Immunol. 2014 Nov;35(11):507-17. doi: 10.1016/j.it.2014.07.010. Epub 2014 Aug 27.
8 CCL20 Displays Antimicrobial Activity Against Cryptosporidium parvum, but Its Expression Is Reduced During Infection in the Intestine of Neonatal Mice.J Infect Dis. 2015 Oct 15;212(8):1332-40. doi: 10.1093/infdis/jiv206. Epub 2015 Apr 2.
9 Bacterial evasion of host immune defense: Yersinia enterocolitica encodes a suppressor for tumor necrosis factor alpha expression. Infect Immun. 1995 Apr;63(4):1270-7.

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