Details of Microbe Species (MIC)

General Information of MIC (ID: MIC00215)
MIC Name Bifidobacterium longum subsp. infantis (actinobacteria)
MIC Synonyms Bifidobacterium longum bv. Infantis
Body Site Gut
Lineage Kingdom: Bacteria
Phylum: Actinobacteria
Class: Actinobacteria
Order: Bifidobacteriales
Family: Bifidobacteriaceae
Genus: Bifidobacterium
Species: Bifidobacterium longum subsp. infantis
Oxygen Sensitivity Anaerobe
Microbial Metabolism Saccharolytic, Fermentative
Gram Positive
Host Relationship Probiotic
Genome Size (bp) 2821883
No. of Coding Genes 2556
No. of Non-Coding Genes 84
No. of Small Non-Coding Genes 84
No. of Gene Transcripts 2640
No. of Base Pairs 2821883
Description Bifidobacterium infantis (B. infantis) is a friendly subspecies of species. Its a type of lactic acid bacteria found in the same group as Lactobacillus. Bifidobacterium infantis is possibly the best known of the Bifidobacterium family and is essential for good health in both babies and adults. It is naturally found in oral cavity and gastrointestinal tract.
External Links Taxonomy ID
1682
Genome Assembly ID
BIC1401212621b.V1
GOLD Organism ID
Go0506786
Disease Relevance
          Digestive system disease  [ICD-11: DE2Z]
             Description Bifidobacterium infantis was a important factor to take into consideration in the treatment or prevention of gastrointestinal disease. [1]
Host Genetic Factors (HGFs)
          rs651821
             HGF ID HGF1924 HGF Info       Class Single Nucleotide Polymorphism: Prime UTR variant (SNP-PV)
             Description The APOA5 SNP rs651821 might be an important host genetic factor in determining the abundances of the health-promoting Bifidobacterium bacteria and the taxa to which this genus belongs. [2]
Host Immune Factors (HIFs)
          C-C motif chemokine 20
             HIF ID HIFM0023 HIF Info       Class Cytokine (Cyt)
             Description Bifidobacterium infantis could-dependently inhibited the secretion of CCL20 by IECs. [3]
          Interferon-10
             HIF ID HIFM0128 HIF Info       Class Cytokine (Cyt)
             Description Bifidobacterium longum subsp. infantis can increase the cytokines IL-10 expression(p<0.05)in mouse colon tissue. [4]
          Transforming growth factor beta-2 proprotein
             HIF ID HIFM0213 HIF Info       Class Cytokine (Cyt)
             Description Bifidobacterium longum subsp. infantis could increase cytokines TGF-1 expression. [4]
Environmental Factor(s)
             Disbiome ID
      349
             gutMDisorder ID
      gm0112
References
1 A meta-analysis of probiotic efficacy for gastrointestinal diseases. PLoS One. 2012;7(4):e34938. doi: 10.1371/journal.pone.0034938. Epub 2012 Apr 18.
2 The effect of heritability and host genetics on the gut microbiota and metabolic syndrome.Gut. 2017 Jun;66(6):1031-1038. doi: 10.1136/gutjnl-2015-311326. Epub 2016 Apr 6.
3 CCL20 Displays Antimicrobial Activity Against Cryptosporidium parvum, but Its Expression Is Reduced During Infection in the Intestine of Neonatal Mice.J Infect Dis. 2015 Oct 15;212(8):1332-40. doi: 10.1093/infdis/jiv206. Epub 2015 Apr 2.
4 Bifidobacterium infantis Induces Protective Colonic PD-L1 and Foxp3 Regulatory T Cells in an Acute Murine Experimental Model of Inflammatory Bowel Disease. Gut Liver. 2019 Mar 15;13(4):430-439. doi: 10.5009/gnl18316.

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