Details of Host Immune Factor (HIF) Regulating Microbe Species (MIC)

General Information of HIF (ID: HIFM0213)
HIF Name
Transforming growth factor beta-2 proprotein
HIF Synonym(s)
TGF-beta ligand, Tgf2
HIF Classification
Cytokine (Cyt)
Molecular Function
Growth factor; Mitogen
Description Transforming growth factor beta-2 (TGF-2) is a secreted protein [1]
Pfam TGF-beta propeptide (PF00688 )
Transforming growth factor beta like domain (PF00019 )
Pathway AGE-RAGE signaling pathway in diabetic complications (hsa04933 )
Amoebiasis (hsa05146 )
Cell cycle (hsa04110 )
Cellular senescence (hsa04218 )
Chagas disease (American trypanosomiasis) (hsa05142 )
Chronic myeloid leukemia (hsa05220 )
Colorectal cancer (hsa05210 )
Cytokine-cytokine receptor interaction (hsa04060 )
Dilated cardiomyopathy (DCM) (hsa05414 )
FoxO signaling pathway (hsa04068 )
Gastric cancer (hsa05226 )
Hepatitis B (hsa05161 )
Hepatocellular carcinoma (hsa05225 )
Hippo signaling pathway (hsa04390 )
Human T-cell leukemia virus 1 infection (hsa05166 )
Hypertrophic cardiomyopathy (HCM) (hsa05410 )
Inflammatory bowel disease (IBD) (hsa05321 )
Leishmaniasis (hsa05140 )
MAPK signaling pathway (hsa04010 )
Malaria (hsa05144 )
MicroRNAs in cancer (hsa05206 )
Osteoclast differentiation (hsa04380 )
Pancreatic cancer (hsa05212 )
Pathways in cancer (hsa05200 )
Proteoglycans in cancer (hsa05205 )
Renal cell carcinoma (hsa05211 )
Rheumatoid arthritis (hsa05323 )
TGF-beta signaling pathway (hsa04350 )
Toxoplasmosis (hsa05145 )
Tuberculosis (hsa05152 )
Sequence Click here to download the HIF sequence in FASTA format
External Links
Uniprot ID
TGFB2_HUMAN
Microbe Species (MIC) Regulated by This HIF
         Actinoplanes (actinobacteria) MIC00040
             Description Pentachloropseudilin isolated first from Actinoplanes could inhibit transforming growth factor- (TGF) activity by accelerating cell-surface type II TGF- receptor turnover. [2]
         Bifidobacterium longum subsp. infantis (actinobacteria) MIC00215
             Description Bifidobacterium longum subsp. infantis could increase cytokines TGF-1 expression. [3]
         Butyricicoccus pullicaecorum (firmicutes) MIC00293
             Description Butyricicoccus pullicaecorum extend the lifespan of Caenorhabditis elegans via the transforming growth factor-beta (TGF-) pathway associated with anti-inflammatory processes in the innate immune system. [4]
         Clostridium butyricum (firmicutes) MIC00388
             Description Clostridium butyricum CGMCC0313.1 is associated with TGF-Beta concentrations. [5]
         Coxiella burnetii (gamma-proteobacteria) MIC00467
             Description Coxiella burnetii-infected macrophages release the transforming growth factor (TGF)- b 1. [6]
         Lactobacillus delbrueckii (firmicutes) MIC00712
             Description Lactobacillus delbrueckii could modulate the production of TGF-beta in the spleen. [7]
         Listeria monocytogenes (firmicutes) MIC00771
             Description Listeria monocytogenes is associated with TGF-Beta concentrations. [8]
         Megasphaera elsdenii (firmicutes) MIC00788
             Description Megasphaera elsdenii extend the lifespan of Caenorhabditis elegans via the transforming growth factor-beta (TGF-) pathway associated with anti-inflammatory processes in the innate immune system. [4]
         Parabacteroides distasonis (CFB bacteria) MIC00949
             Description Parabacteroides distasonis is associated with TGF- concentrations. [9]
         Photorhabdus asymbiotica (enterobacteria) MIC00988
             Description The transforming growth factor-beta (TGF-beta) signaling is in Drosophila melanogaster,which is infected by Photorhabdus asymbiotica bacteria. [10]
         Prevotellaceae (CFB bacteria) MIC01028
             Description The increased abundance of the Prevotellaceae was associated with the enriched concentrations of TGF- in serum. [11]
         Pseudomonas sp. (gamma-proteobacteria) MIC01053
             Description Gene expression of pro-inflammatory cytokine TNF-2 was consistently and significantly induced by Pseudomonas plecoglossicida infection. [12]
         Streptococcus sp. (firmicutes) MIC01276
             Description Higher concentrations of TGF-beta2 was associated with the increased relative abundance of several bacteria such as streptococcaceae(FDR adjusted p-value<0.05). [13]
References
1 TGF-1 and TGF-2 abundance in liver diseases of mice and men.Oncotarget. 2016 Apr 12;7(15):19499-518. doi: 10.18632/oncotarget.6967.
2 Pentachloropseudilin Inhibits Transforming Growth Factor- (TGF-) Activity by Accelerating Cell-Surface Type II TGF- Receptor Turnover in Target Cells. Chembiochem. 2018 Apr 16;19(8):851-864. doi: 10.1002/cbic.201700693. Epub 2018 Mar 2.
3 Bifidobacterium infantis Induces Protective Colonic PD-L1 and Foxp3 Regulatory T Cells in an Acute Murine Experimental Model of Inflammatory Bowel Disease. Gut Liver. 2019 Mar 15;13(4):430-439. doi: 10.5009/gnl18316.
4 Lifespan Extension of Caenorhabditis elegans by Butyricicoccus pullicaecorum and Megasphaera elsdenii with Probiotic Potential. Curr Microbiol. 2018 May;75(5):557-564. doi: 10.1007/s00284-017-1416-6. Epub 2017 Dec 8.
5 Clostridium butyricum CGMCC0313.1 Protects against Autoimmune Diabetes by Modulating Intestinal Immune Homeostasis and Inducing Pancreatic Regulatory T Cells. Front Immunol. 2017 Oct 19;8:1345. doi: 10.3389/fimmu.2017.01345. eCollection 2017.
6 Immune response and Coxiella burnetii invasion. Adv Exp Med Biol. 2012;984:287-98. doi: 10.1007/978-94-007-4315-1_15.
7 Local and systemic immune mechanisms underlying the anti-colitis effects of the dairy bacterium Lactobacillus delbrueckii. PLoS One. 2014 Jan 21;9(1):e85923. doi: 10.1371/journal.pone.0085923. eCollection 2014.
8 HDAC6 controls innate immune and autophagy responses to TLR-mediated signalling by the intracellular bacteria Listeria monocytogenes. PLoS Pathog. 2017 Dec 27;13(12):e1006799. doi: 10.1371/journal.ppat.1006799. eCollection 2017 Dec.
9 Oral administration of Parabacteroides distasonis antigens attenuates experimental murine colitis through modulation of immunity and microbiota composition. Clin Exp Immunol. 2011 Feb;163(2):250-9. doi: 10.1111/j.1365-2249.2010.04286.x. Epub 2010 Nov 19.
10 TGF- Signaling Interferes With the Drosophila Innate Immune and Metabolic Response to Parasitic Nematode Infection. Front Physiol. 2019 Jun 19;10:716. doi: 10.3389/fphys.2019.00716. eCollection 2019.
11 Prebiotic, immuno-stimulating and gut microbiota-modulating effects of Lycium barbarum polysaccharide. Biomed Pharmacother. 2020 Jan;121:109591. doi: 10.1016/j.biopha.2019.109591. Epub 2019 Nov 13.
12 Immune and gut bacterial successions of large yellow croaker (Larimichthys crocea) during Pseudomonas plecoglossicida infection. Fish Shellfish Immunol. 2020 Apr;99:176-183. doi: 10.1016/j.fsi.2020.01.063. Epub 2020 Feb 1.
13 Breast Milk Transforming Growth Factor Is Associated With Neonatal Gut Microbial Composition. J Pediatr Gastroenterol Nutr. 2017 Sep;65(3):e60-e67. doi: 10.1097/MPG.0000000000001585.

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