Details of Microbe Species (MIC)

General Information of MIC (ID: MIC00293)
MIC Name Butyricicoccus pullicaecorum (firmicutes)
Body Site Gut
Lineage Kingdom: Bacteria
Phylum: Firmicutes
Class: Clostridia
Order: Clostridiales
Family: Clostridiaceae
Genus: Butyricicoccus
Species: Butyricicoccus pullicaecorum
Oxygen Sensitivity Facultative anaerobe
Microbial Metabolism Saccharolytic; Respiratory or Fermentative
Gram Positive
Host Relationship Potential probiotic
Genome Size (bp) 3299519
Description Butyricicoccus pullicaecorum is a facultative anaerobic, Gram positive bacterium. It is such a promising probiotic candidate for people suffering from inflammatory bowel disease.
External Links Taxonomy ID
501571
Genome Assembly ID
Buty_pull_1_20_V1
GOLD Organism ID
Go0021062
Disease Relevance
          Autoimmune liver disease  [ICD-11: DB96]
             Description Butyricicoccus pullicaecorum was associated with primary sclerosing cholangitis. [1]
          Inflammatory bowel disease  [ICD-11: DD72]
             Description Patients with inflammatory bowel disease have lower numbers of Butyricicoccus bacteria in their stools. [2]
          Ulcerative colitis  [ICD-11: DD71]
             Description Ulcerative colitis phenotype was characterized by a substantial decrease of Butyricicoccus pullicaecorum sp.. [1]
Host Genetic Factors (HGFs)
          VDR
             HGF ID HGF2353 HGF Info       Class Copy Number Variation: Gene Deletion (CNV-GDe)
             Description The percentage of abundance of butyrate-producing bacteria significantly dropped in VDR deletion mice (p-value<0.05). [3]
          rs571312
             HGF ID HGF2159 HGF Info       Class Single Nucleotide Polymorphism (SNP)
             Description The variant gene MC4R of innate immunity rs571312 is significantly associated with the abundance of gut micriobiota Butyricicoccus pullicaecorum (p-value=0.0002). [4]
          rs758139
             HGF ID HGF1493 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs758139 SNP was significantly associated with the abundance of Butyricicoccus (p-value=4.59E-07). [5]
          rs2320952
             HGF ID HGF1494 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs2320952 SNP was significantly associated with the abundance of Butyricicoccus (p-value=2.63E-07). [5]
          rs11651216
             HGF ID HGF1495 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs11651216 SNP was significantly associated with the abundance of Butyricicoccus (p-value=4.59E-07). [5]
Host Immune Factors (HIFs)
          Interferon-12 subunit alpha
             HIF ID HIFM0130 HIF Info       Class Cytokine (Cyt)
             Description Butyricicoccus pullicaecorum decreased IL-12 expression levels. [2]
          C-X-C motif chemokine 8
             HIF ID HIFM0153 HIF Info       Class Cytokine (Cyt)
             Description Supernatant of Butyricicoccus pullicaecorum prevented the increase in IL-8 secretion induced by TNF-alpha and interferon-gamma. [2]
          Transforming growth factor beta-2 proprotein
             HIF ID HIFM0213 HIF Info       Class Cytokine (Cyt)
             Description Butyricicoccus pullicaecorum extend the lifespan of Caenorhabditis elegans via the transforming growth factor-beta (TGF-) pathway associated with anti-inflammatory processes in the innate immune system. [6]
          Tumor necrosis factor
             HIF ID HIFM0226 HIF Info       Class Cytokine (Cyt)
             Description Butyricicoccus pullicaecorum could decrease the level of tumour necrosis factor Alpha(TNFAlpha). [2]
          Neutrophils
             HIF ID HIFC0029 HIF Info       Class Granulocytes (Gra)
             Description Butyricicoccus spp. at neutrophil recovery was negatively correlated with subsequent acute severe graft-versus-host disease. [7]
Environmental Factor(s)
             Disbiome ID
      696
             gutMDisorder ID
      gm0135
References
1 Distinct gut microbiota profiles in patients with primary sclerosing cholangitis and ulcerative colitis. World J Gastroenterol. 2017 Jul 7;23(25):4548-4558. doi: 10.3748/wjg.v23.i25.4548.
2 Butyricicoccus pullicaecorum in inflammatory bowel disease. Gut. 2013 Dec;62(12):1745-52. doi: 10.1136/gutjnl-2012-303611. Epub 2012 Dec 22.
3 Vitamin D receptor promotes healthy microbial metabolites and microbiome.Sci Rep. 2020 Apr 30;10(1):7340. doi: 10.1038/s41598-020-64226-7.
4 Variants in genes of innate immunity, appetite control and energy metabolism are associated with host cardiometabolic health and gut microbiota composition.Gut Microbes. 2020 May 3;11(3):556-568. doi: 10.1080/19490976.2019.1619440. Epub 2019 Jun 3.
5 Genome-Wide Association Studies of the Human Gut Microbiota.PLoS One. 2015 Nov 3;10(11):e0140301. doi: 10.1371/journal.pone.0140301. eCollection 2015.
6 Lifespan Extension of Caenorhabditis elegans by Butyricicoccus pullicaecorum and Megasphaera elsdenii with Probiotic Potential. Curr Microbiol. 2018 May;75(5):557-564. doi: 10.1007/s00284-017-1416-6. Epub 2017 Dec 8.
7 Stool Microbiota at Neutrophil Recovery Is Predictive for Severe Acute Graft vs Host Disease After Hematopoietic Cell Transplantation.Clin Infect Dis. 2017 Nov 29;65(12):1984-1991. doi: 10.1093/cid/cix699.

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