General Information of MIC (ID: MIC01053)
MIC Name	Pseudomonas sp. (gamma-proteobacteria)
Body Site	Ocular Surface
Lineage	Kingdom: Bacteria Phylum: Proteobacteria Class: Gammaproteobacteria Order: Pseudomonadales Family: Pseudomonadaceae Genus: Pseudomonas Species: Pseudomonas sp.
Oxygen Sensitivity	Aerobe
Microbial Metabolism	Respiratory
Gram	Negative
Host Relationship	Commensal
Description	Pseudomonas is a genus of Gram-negative, Gammaproteobacteria, belonging to the family Pseudomonadaceae.
External Links	Taxonomy ID	306
	GOLD Organism ID	Go0546796
Disease Relevance
Coeliac disease  [ICD-11: DA95]
Description	Pseudomonas was associated with non-celiac gluten sensitivity.				[1]

Host Genetic Factors (HGFs)
hsa-miR-146a-5p
HGF ID	HGF0252	HGF Info	Class	Non-coding RNA: Micro (ncRNA-miRNA)
Description	Pseudomonas monospecies biofilm induced the expression level of miR-146a.				[2]

Host Immune Factors (HIFs)
Eosinophil cationic protein
HIF ID	HIFM0094	HIF Info	Class	Antimicrobial peptide (AMP)
Description	The RNase 3 showed >10 bactericidal activity against Pseudomonas sp. when the hemolytic activity of 11.2+0.1M or 11.2-0.1M and the peptide size reduction of 48%.				[3]
Interferon-10
HIF ID	HIFM0128	HIF Info	Class	Cytokine (Cyt)
Description	Gene expression of anti-inflammatory cytokine IL-10 was consistently and significantly induced by Pseudomonas plecoglossicida infection.				[4]
Interleukin-1 beta
HIF ID	HIFM0138	HIF Info	Class	Cytokine (Cyt)
Description	The gene expression of IL-1beta was consistently and significantly induced by Pseudomonas infection.				[4]
Transforming growth factor beta-2 proprotein
HIF ID	HIFM0213	HIF Info	Class	Cytokine (Cyt)
Description	Gene expression of pro-inflammatory cytokine TNF-2 was consistently and significantly induced by Pseudomonas plecoglossicida infection.				[4]
Tumor necrosis factor
HIF ID	HIFM0226	HIF Info	Class	Cytokine (Cyt)
Description	Gene expression of pro-inflammatory cytokine TNF-1 was consistently and significantly induced by Pseudomonas plecoglossicida infection.				[4]

Environmental Factor(s)
Disbiome ID			319
gutMDisorder ID			gm0550

References
1	First Insights into the Gut Microbiota of Mexican Patients with Celiac Disease and Non-Celiac Gluten Sensitivity. Nutrients. 2018 Nov 2;10(11):1641. doi: 10.3390/nu10111641.
2	Altered Fecal Small RNA Profiles in Colorectal Cancer Reflect Gut Microbiome Composition in Stool Samples. Tarallo S, Ferrero G, Gallo G, Francavilla A, Clerico G, Realis Luc A, Manghi P, Thomas AM, Vineis P, Segata N, Pardini B, Naccarati A, Cordero F.. mSystems. 2019 Sep 17;4(5):e00289-19. doi: 10.1128/mSystems.00289-19.
3	Exploring the mechanisms of action of human secretory RNase 3 and RNase 7 against Candida albicans.Microbiologyopen. 2016 Oct;5(5):830-845. doi: 10.1002/mbo3.373. Epub 2016 Jun 8.
4	Immune and gut bacterial successions of large yellow croaker (Larimichthys crocea) during Pseudomonas plecoglossicida infection. Fish Shellfish Immunol. 2020 Apr;99:176-183. doi: 10.1016/j.fsi.2020.01.063. Epub 2020 Feb 1.

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