General Information of MIC (ID: MIC00467)
MIC Name	Coxiella burnetii (gamma-proteobacteria)
MIC Synonyms	Rickettsia burneti
Body Site	Gut
Lineage	Kingdom: Bacteria Phylum: Proteobacteria Class: Gammaproteobacteria Order: Legionellales Family: Coxiellaceae Genus: Coxiella Species: Coxiella burnetii
Oxygen Sensitivity	Aerobe
Microbial Metabolism	Glycolysis; Gluconeogenesis; Pentose phosphate pathway; TCA cycle
Gram	Negative
Host Relationship	Pathogen
Genome Size (bp)	2130797
No. of Coding Genes	2097
No. of Non-Coding Genes	47
No. of Small Non-Coding Genes	47
No. of Gene Transcripts	2144
No. of Base Pairs	2214254
Description	Coxiella burnetii is an obligate intracellular Gram-negative coccobacillus bacterium that is known to be the main pathogen that causes Q fever in mammals and humans. It is highly resistant to environmental stresses such as high temperature, osmotic pressure, and ultraviolet light.
External Links	Taxonomy ID	777
	Genome Assembly ID	ASM96707v1
	GOLD Organism ID	Go0519379

Host Genetic Factors (HGFs)
rs7851696
HGF ID	HGF1776	HGF Info	Class	Single Nucleotide Polymorphism: Missense variant (SNP-MV)
Description	The rs7851696 SNP was significantly associated with the abundance of Coxiella burnetii (p-value<0.05).				[1]
rs17549193
HGF ID	HGF1777	HGF Info	Class	Single Nucleotide Polymorphism: Missense variant (SNP-MV)
Description	The rs17549193 SNP was significantly associated with the abundance of Coxiella burnetii (p-value<0.05).				[1]

Host Immune Factors (HIFs)
Interferon-10
HIF ID	HIFM0128	HIF Info	Class	Cytokine (Cyt)
Description	The persistent Coxiella burnetii infection in mice over expressing IL-10.				[2]
Interleukin-1 receptor antagonist protein
HIF ID	HIFM0140	HIF Info	Class	Cytokine (Cyt)
Description	Coxiella burnetii replication is associated with an M2 program characterized by the up-regulation of IL-1 receptor antagonist (IL1-ra) in monocytes.				[2]
Transforming growth factor beta-2 proprotein
HIF ID	HIFM0213	HIF Info	Class	Cytokine (Cyt)
Description	Coxiella burnetii-infected macrophages release the transforming growth factor (TGF)- b 1.				[2]
Interferon gamma
HIF ID	HIFM0260	HIF Info	Class	Cytokine (Cyt)
Description	The abundance of Coxiella burnetii is associated with IFN-Gamma.				[2]
Macrophages
HIF ID	HIFC0020	HIF Info	Class	Macrophages (Mac)
Description	Macrophages are well-known targets of Coxiella burnetii.				[2]
Monocytes
HIF ID	HIFC0024	HIF Info	Class	Monocytes (Mono)
Description	Monocytes are well-known targets of Coxiella burnetii.				[2]
Regulatory T cells
HIF ID	HIFC0030	HIF Info	Class	T cells (TCs)
Description	A significant increase in Tregs expressing Foxp3 was observed in the patients with Q fever endocarditis with Coxiella burnetii infection.				[2]
T-cell-specific surface glycoprotein CD28
HIF ID	HIFM0046	HIF Info	Class	T-cell receptor (TCR)
Description	Increasing injected doses to 5 106 Coxiella burnetii organisms did not change mortality and morbidity of wt and CD28 / mice.				[3]

References
1	Mannose-binding lectin and l-ficolin polymorphisms in patients with community-acquired pneumonia caused by intracellular pathogens.Immunology. 2017 May;151(1):81-88. doi: 10.1111/imm.12705. Epub 2017 Jan 24.
2	Immune response and Coxiella burnetii invasion. Adv Exp Med Biol. 2012;984:287-98. doi: 10.1007/978-94-007-4315-1_15.
3	Role for the CD28 molecule in the control of Coxiella burnetii infection.Infect Immun. 2006 Mar;74(3):1800-8. doi: 10.1128/IAI.74.3.1800-1808.2006.

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