General Information of HIF (ID: HIFC0030)
HIF Name	Regulatory T cells
HIF Synonym(s)	Regulatory T cells
HIF Classification	T cells (TCs)
Description	Treg cells develop in the thymus and are released upon stimulation by chemokines released from a site of injury or inflammation. The cells migrate to the site and nearby lymph nodes. There, immunosuppression results from direct interactions with effector cells.				[1]

Microbe Species (MIC) Regulated by This HIF
Akkermansia muciniphila (verrucomicrobia)			MIC00056
Description	Akkermansia muciniphila is associated with Treg responses.				[2]
Bacteroides fragilis (CFB bacteria)			MIC00158
Description	Bacteroides fragilis induces IL-10-producing regulatory T (Treg) cells in the colon via capsular expression of polysaccharide A.				[3]
Bacteroides sp. (CFB bacteria)			MIC00176
Description	Bacteroidales induced the transcription factor RORt in nascent Treg cells.				[4]
Barnesiella intestinihominis (CFB bacteria)			MIC00192
Description	Barnesiella intestinihominis is associated with Tregs responses.				[5]
Bifidobacterium breve (actinobacteria)			MIC00210
Description	Bifidobacterium breve M-16V+ LRG significantly increased the Treg proportion in large intestinal LPL CD4+ cells.				[6]
Butyrivibrio fibrisolvens (firmicutes)			MIC00296
Description	Butyrivibrio is associated with regulatory T cells responses.				[7]
Citrobacter rodentium (enterobacteria)			MIC00366
Description	Citrobacter rodentium is associated with Tregs responses.				[8]
Clostridium butyricum (firmicutes)			MIC00388
Description	Clostridium butyricum CGMCC0313.1 could induce Tregs.				[9]
Clostridium leptum (firmicutes)			MIC00402
Description	Early-life Clostridium leptum exposure induced an immunosuppressive environment in the lung concurrent with increased Treg cells.				[10]
Clostridium sp. (firmicutes)			MIC00418
Description	Clostridiales has the potential to induce Tregs immunity response.				[11]
Collinsella aerofaciens (actinobacteria)			MIC00432
Description	Collinsella aerofaciens is associated with Tregs responses.				[8]
Coxiella burnetii (gamma-proteobacteria)			MIC00467
Description	A significant increase in Tregs expressing Foxp3 was observed in the patients with Q fever endocarditis with Coxiella burnetii infection.				[12]
Faecalibacterium sp. (firmicutes)			MIC00589
Description	The abundance of Faecalibacterium increased in the patients with high numbers of Tregs.				[13]
Helicobacter hepaticus (epsilon-proteobacteria)			MIC00666
Description	Some regulatory T cells can inhibit and treat Helicobacter hepaticus-induced innate inflammation in the lower bowel, based on an IL-10-dependent mechanism.				[14]
Lactobacillus paraplantarum (firmicutes)			MIC00727
Description	Lactobacillus paraplantarum with significant content variations was associated with the Tregs differentiation.				[15]
Lactobacillus reuteri (firmicutes)			MIC00731
Description	Lactobacillus reuteri could induce anti-inflammatory Treg cells.				[16]
Lactobacillus sp. (firmicutes)			MIC00701
Description	Treg cells are thymic Treg cells that can recognize bacterial antigens from Lactobacillus.				[17]
Roseburia sp. (firmicutes)			MIC01115
Description	Roseburia is known to produce short chain fatty acids, which in their turn are known to induce Tregs(Regulatory cells).				[18]
Ruminococcus sp. (firmicutes)			MIC01140
Description	Ruminococcus is associated with regulatory T cells responses.				[19]

References
1	Dexamethasone affects day/night development and function of thymus-derived T regulatory cells.Immunobiology. 2019 Sep;224(5):614-624. doi: 10.1016/j.imbio.2019.07.007. Epub 2019 Aug 7.
2	Pili-like proteins of Akkermansia muciniphila modulate host immune responses and gut barrier function. PLoS One. 2017 Mar 1;12(3):e0173004. doi: 10.1371/journal.pone.0173004. eCollection 2017.
3	Interactions between the microbiota, immune and nervous systems in health and disease. Nat Neurosci. 2017 Feb;20(2):145-155. doi: 10.1038/nn.4476. Epub 2017 Jan 16.
4	Regulation of oral immune tolerance by the microbiome in food allergy. Curr Opin Immunol. 2019 Oct;60:141-147. doi: 10.1016/j.coi.2019.06.001. Epub 2019 Jul 11.
5	Enterococcus hirae and Barnesiella intestinihominis Facilitate Cyclophosphamide-Induced Therapeutic Immunomodulatory Effects. Immunity. 2016 Oct 18;45(4):931-943. doi: 10.1016/j.immuni.2016.09.009. Epub 2016 Oct 4.
6	The Combination of Bifidobacterium breve and Three Prebiotic Oligosaccharides Modifies Gut Immune and Endocrine Functions in Neonatal Mice. J Nutr. 2019 Feb 1;149(2):344-353. doi: 10.1093/jn/nxy248.
7	Relative abundance of Megamonas hypermegale and Butyrivibrio species decreased in the intestine and its possible association with the T cell aberration by metabolite alteration in patients with Behcet's disease (210 characters). Clin Rheumatol. 2019 May;38(5):1437-1445. doi: 10.1007/s10067-018-04419-8. Epub 2019 Jan 9.
8	A cross talk between dysbiosis and gut-associated immune system governs the development of inflammatory arthropathies. Semin Arthritis Rheum. 2019 Dec;49(3):474-484. doi: 10.1016/j.semarthrit.2019.05.007. Epub 2019 May 31.
9	Clostridium butyricum CGMCC0313.1 Protects against Autoimmune Diabetes by Modulating Intestinal Immune Homeostasis and Inducing Pancreatic Regulatory T Cells. Front Immunol. 2017 Oct 19;8:1345. doi: 10.3389/fimmu.2017.01345. eCollection 2017.
10	Early-Life Exposure to Clostridium leptum Causes Pulmonary Immunosuppression. PLoS One. 2015 Nov 13;10(11):e0141717. doi: 10.1371/journal.pone.0141717. eCollection 2015.
11	Expression of immune regulatory genes correlate with the abundance of specific Clostridiales and Verrucomicrobia species in the equine ileum and cecum. Sci Rep. 2019 Sep 3;9(1):12674. doi: 10.1038/s41598-019-49081-5.
12	Immune response and Coxiella burnetii invasion. Adv Exp Med Biol. 2012;984:287-98. doi: 10.1007/978-94-007-4315-1_15.
13	Characterization of tumor-infiltrating immune cells in relation to microbiota in colorectal cancers. Cancer Immunol Immunother. 2020 Jan;69(1):23-32. doi: 10.1007/s00262-019-02433-6. Epub 2019 Nov 26.
14	Helicobacter hepaticus infection in mice: models for understanding lower bowel inflammation and cancer. Mucosal Immunol. 2011 Jan;4(1):22-30. doi: 10.1038/mi.2010.61. Epub 2010 Oct 13.
15	Whole Body Vibration Triggers a Change in the Mutual Shaping State of Intestinal Microbiota and Body's Immunity. Front Bioeng Biotechnol. 2019 Nov 29;7:377. doi: 10.3389/fbioe.2019.00377. eCollection 2019.
16	Probiotics Lactobacillus reuteri Abrogates Immune Checkpoint Blockade-Associated Colitis by Inhibiting Group 3 Innate Lymphoid Cells. Front Immunol. 2019 Jun 4;10:1235. doi: 10.3389/fimmu.2019.01235. eCollection 2019.
17	Microbiota and host immune responses: a love-hate relationship. Immunology. 2016 Jan;147(1):1-10. doi: 10.1111/imm.12538. Epub 2015 Nov 2.
18	Microbiota Induced Changes in the Immune Response in Pregnant Mice. Front Immunol. 2020 Jan 9;10:2976. doi: 10.3389/fimmu.2019.02976. eCollection 2019.
19	Microbial genes and pathways in inflammatory bowel disease. Nat Rev Microbiol. 2019 Aug;17(8):497-511. doi: 10.1038/s41579-019-0213-6.

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