Details of Microbe Species (MIC)

General Information of MIC (ID: MIC00432)
MIC Name Collinsella aerofaciens (actinobacteria)
MIC Synonyms Bacteroides aerofaciens
Body Site Gut
Lineage Kingdom: Bacteria
Phylum: Actinobacteria
Class: Coriobacteriia
Order: Coriobacteriales
Family: Coriobacteriaceae
Genus: Collinsella
Species: Collinsella aerofaciens
Oxygen Sensitivity Obligate anaerobe
Microbial Metabolism Saccharolytic; Fermentative
Gram Positive
Host Relationship Commensal
Genome Size (bp) 2439869
Description Collinsella aerofaciens also named Bacteroides aerofaciens, is a species of obligate anaerobic, Gram posotive bacterium in the order Collinsella. It was found in the gut and also on the surface of the tongue.
External Links Taxonomy ID
74426
Genome Assembly ID
ASM16903v1
GOLD Organism ID
Go0517375
Disease Relevance
          Coeliac disease  [ICD-11: DA95]
             Description Collinsella aerofaciens was associated with celiac disease. [1]
          Inflammatory bowel disease  [ICD-11: DD72]
             Description Collinsella aerofaciens was associated with inflammatory bowel disease. [1]
          Obesity  [ICD-11: 5B81]
             Description Collinsella aerofaciens was associated with genetic variants in Obesity. [2]
Host Genetic Factors (HGFs)
          rs6923761
             HGF ID HGF1753 HGF Info       Class Single Nucleotide Polymorphism: Missense variant (SNP-MV)
             Description The variant gene GLP1R of innate immunity rs6923761 is significantly associated with the abundance of gut micriobiota Collinsella aerofaciens (p-value=0.0137). [3]
          rs913678
             HGF ID HGF2624 HGF Info       Class Single Nucleotide Polymorphism (SNP)
             Description The rs913678 SNP is associated with the abundance of Collinsella aerofaciens. [4]
          rs1893217
             HGF ID HGF2625 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs1893217 SNP is associated with the abundance of Collinsella aerofaciens. [4]
          rs17293632
             HGF ID HGF2626 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs17293632 SNP is associated with the abundance of Collinsella aerofaciens. [4]
          rs3197999
             HGF ID HGF2627 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-MV)
             Description The rs3197999 SNP is associated with the abundance of Collinsella aerofaciens. [4]
          rs1250546
             HGF ID HGF2565 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs1250546 SNP is associated with the abundance of Collinsella aerofaciens. [4]
          rs17229285
             HGF ID HGF2578 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs17229285 SNP is associated with the abundance of Collinsella aerofaciens. [4]
          rs7608910
             HGF ID HGF2613 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs7608910 SNP is associated with the abundance of Collinsella aerofaciens. [4]
          rs6740462
             HGF ID HGF2537 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs6740462 SNP is associated with the abundance of Collinsella aerofaciens. [4]
          rs7097656
             HGF ID HGF2572 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs7097656 SNP is associated with the abundance of Collinsella aerofaciens. [4]
Host Immune Factors (HIFs)
          Programmed death-ligand 1
             HIF ID HIFM0189 HIF Info       Class Checkpoint molecule (CM)
             Description Collinsella aerofaciens enrichment contributed to better response to anti-PD-L1 therapy. [5]
          Regulatory T cells
             HIF ID HIFC0030 HIF Info       Class T cells (TCs)
             Description Collinsella aerofaciens is associated with Tregs responses. [6]
Environmental Factor(s)
             Disbiome ID
      786
             gutMDisorder ID
      gm0217
References
1 Oral versus intravenous iron replacement therapy distinctly alters the gut microbiota and metabolome in patients with IBD. Gut. 2017 May;66(5):863-871. doi: 10.1136/gutjnl-2015-309940. Epub 2016 Feb 4.
2 M-GWAS for the gut microbiome in Chinese adults illuminates on complex diseases. bioRxiv, 2019.
3 Variants in genes of innate immunity, appetite control and energy metabolism are associated with host cardiometabolic health and gut microbiota composition.Gut Microbes. 2020 May 3;11(3):556-568. doi: 10.1080/19490976.2019.1619440. Epub 2019 Jun 3.
4 A Microbe Associated with Sleep Revealed by a Novel Systems Genetic Analysis of the Microbiome in Collaborative Cross Mice. Genetics. 2020 Mar;214(3):719-733. doi: 10.1534/genetics.119.303013. Epub 2020 Jan 2.
5 Modulation of gut microbiota to overcome resistance to immune checkpoint blockade in cancer immunotherapy.Curr Opin Pharmacol. 2020 Jun 30;54:1-10. doi: 10.1016/j.coph.2020.06.004. Online ahead of print.
6 A cross talk between dysbiosis and gut-associated immune system governs the development of inflammatory arthropathies. Semin Arthritis Rheum. 2019 Dec;49(3):474-484. doi: 10.1016/j.semarthrit.2019.05.007. Epub 2019 May 31.

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