Details of Microbe Species (MIC)

General Information of MIC (ID: MIC00589)
MIC Name Faecalibacterium sp. (firmicutes)
Body Site Vagina
Lineage Kingdom: Bacteria
Phylum: Firmicutes
Class: Clostridia
Order: Clostridiales
Family: Ruminococcaceae
Genus: Faecalibacterium
Species: Faecalibacterium sp.
Oxygen Sensitivity Anaerobe
Microbial Metabolism Saccharolytic; Fermentative
Gram Positive
Host Relationship Commensal
Description Faecalibacterium is a genus of bacteria. This bacteria is considered beneficial and is one of the most prevalent intestinal bacterial species in healthy adults.
External Links Taxonomy ID
1971605
GOLD Organism ID
Go0546686
Disease Relevance
          Autism spectrum disorder  [ICD-11: 6A02]
             Description Faecalibacterium spp. was significantly elevated in autistic children. [1]
          Crohn disease  [ICD-11: DD70]
             Description Faecalibacterium was deficient in Crohns disease patients. [2]
          Non-alcoholic fatty liver disease  [ICD-11: DB92]
             Description The decrease in Faecalibacterium was related to the pathogenesis of nonalcoholic fatty liver disease. [3]
          Type 2 diabetes mellitus  [ICD-11: 5A11]
             Description Faecalibacterium was associated with genetic variants in Type 2 diabetes. [4]
Host Genetic Factors (HGFs)
          rs9434172
             HGF ID HGF2306 HGF Info       Class Single Nucleotide Polymorphism (SNP)
             Description The rs9434172 SNP was significantly associated with the abundance of Faecalibacterium (p-value=3.70E-06). [5]
          rs9434166
             HGF ID HGF2308 HGF Info       Class Single Nucleotide Polymorphism (SNP)
             Description The rs9434166 SNP was significantly associated with the abundance of Faecalibacterium (p-value=3.70E-06). [5]
          rs910633
             HGF ID HGF2307 HGF Info       Class Single Nucleotide Polymorphism (SNP)
             Description The rs910633 SNP was significantly associated with the abundance of Faecalibacterium (p-value=3.70E-06). [5]
          rs1517426
             HGF ID HGF2305 HGF Info       Class Single Nucleotide Polymorphism (SNP)
             Description The rs1517426 SNP was significantly associated with the abundance of Faecalibacterium (p-value=1.25E-06). [5]
          rs1394174
             HGF ID HGF1848 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs1394174 SNP was significantly associated with the relative abundance of Faecalibacterium (p-value=6.44E-09). [6]
          rs10747493
             HGF ID HGF1906 HGF Info       Class Single Nucleotide Polymorphism: Missense variant (SNP-MV)
             Description The rs10747493 SNP was significantly associated with the abundance of Faecalibacterium (p-value=8.08E-07). [7]
          rs597205
             HGF ID HGF1701 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs597205 SNP was significantly associated with the abundance of Faecalibacterium (p-value=7.68E-9). [8]
          rs6920220
             HGF ID HGF2532 HGF Info       Class Single Nucleotide Polymorphism (SNP)
             Description The rs6920220 SNP is associated with the abundance of Faecalibacterium. [9]
          rs925255
             HGF ID HGF2557 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs925255 SNP is associated with the abundance of Faecalibacterium. [9]
          rs5743289
             HGF ID HGF2558 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs5743289 SNP is associated with the abundance of Faecalibacterium. [9]
Host Immune Factors (HIFs)
          Inducible T-cell costimulator
             HIF ID HIFM0124 HIF Info       Class Checkpoint molecule (CM)
             Description The ICOS molecule is significantly up-regulated on CD41 T cells after ipilimumab treatment in patients who belong to Faecalibacterium-driven cluster A. [10]
          Programmed death-ligand 1
             HIF ID HIFM0189 HIF Info       Class Checkpoint molecule (CM)
             Description The response to anti-PD-L1 therapy significantly correlated with fecal transplantations from patients abundant in Faecalibacterium. [11]
          Programmed Cell Death 1 Protein
             HIF ID HIFM0191 HIF Info       Class Checkpoint molecule (CM)
             Description The abundance of Faecalibacterium genus was associated with increased CD8+ TILs and peripheral blood CD4+/CD8+ T-cells in human responders to PD-1 blockade. [11]
          Kupffer macrophages
             HIF ID HIFC0169 HIF Info       Class Macrophages (Mac)
             Description Faecalibacterium can cause significant Kupffer cells hyperplasia. [12]
          CD16+ Natural Killer cells
             HIF ID HIFC0094 HIF Info       Class Natural killer cells (NKCs)
             Description The increased proportion of CD16+ NK cells was associated with the decrease of gut commensal bacteria(Faecalibacterium). [13]
          Regulatory T cells
             HIF ID HIFC0030 HIF Info       Class T cells (TCs)
             Description The abundance of Faecalibacterium increased in the patients with high numbers of Tregs. [14]
          Foxp3+CD45RA regulatory T cells
             HIF ID HIFC0184 HIF Info       Class T cells (TCs)
             Description The abundance of Faecalibacterium increased in the patients with clearly high distribution of FOXp3highCD45RA Tregs. [14]
Environmental Factor(s)
             Disbiome ID
      65
             gutMDisorder ID
      gm0326
References
1 The Possible Role of the Microbiota-Gut-Brain-Axis in Autism Spectrum Disorder. Int J Mol Sci. 2019 Apr 29;20(9):2115. doi: 10.3390/ijms20092115.
2 Influences of intestinal bacteria in human inflammatory bowel disease. Infect Dis Clin North Am. 2010 Dec;24(4):977-93, ix. doi: 10.1016/j.idc.2010.07.008.
3 Significant decrease in Faecalibacterium among gut microbiota in nonalcoholic fatty liver disease: a large BMI- and sex-matched population study. Hepatol Int. 2019 Nov;13(6):748-756. doi: 10.1007/s12072-019-09987-8. Epub 2019 Sep 12.
4 M-GWAS for the gut microbiome in Chinese adults illuminates on complex diseases. bioRxiv, 2019.
5 Genome-Wide Association Studies of the Human Gut Microbiota.PLoS One. 2015 Nov 3;10(11):e0140301. doi: 10.1371/journal.pone.0140301. eCollection 2015.
6 Association of host genome with intestinal microbial composition in a large healthy cohort.Nat Genet. 2016 Nov;48(11):1413-1417. doi: 10.1038/ng.3693. Epub 2016 Oct 3.
7 Host genetic variation impacts microbiome composition across human body sites.Genome Biol. 2015 Sep 15;16(1):191. doi: 10.1186/s13059-015-0759-1.
8 Genome-wide association analysis identifies variation in vitamin D receptor and other host factors influencing the gut microbiota.Nat Genet. 2016 Nov;48(11):1396-1406. doi: 10.1038/ng.3695. Epub 2016 Oct 10.
9 A Microbe Associated with Sleep Revealed by a Novel Systems Genetic Analysis of the Microbiome in Collaborative Cross Mice. Genetics. 2020 Mar;214(3):719-733. doi: 10.1534/genetics.119.303013. Epub 2020 Jan 2.
10 Baseline gut microbiota predicts clinical response and colitis in metastatic melanoma patients treated with ipilimumab.Ann Oncol. 2019 Dec 1;30(12):2012. doi: 10.1093/annonc/mdz224.
11 The gut microbiome and response to immune checkpoint inhibitors: preclinical and clinical strategies.Clin Transl Med. 2019 Mar 18;8(1):9. doi: 10.1186/s40169-019-0225-x.
12 Fecal Microbiota of Diarrhea-Predominant Irritable Bowel Syndrome Patients Causes Hepatic Inflammation of Germ-Free Rats and Berberine Reverses It Partially.Biomed Res Int. 2019 Apr 3;2019:4530203. doi: 10.1155/2019/4530203. eCollection 2019.
13 Dysbiosis of gut microbiome affecting small intestine morphology and immune balance: a rhesus macaque model.Zool Res. 2020 Jan 18;41(1):20-31. doi: 10.24272/j.issn.2095-8137.2020.004.
14 Characterization of tumor-infiltrating immune cells in relation to microbiota in colorectal cancers. Cancer Immunol Immunother. 2020 Jan;69(1):23-32. doi: 10.1007/s00262-019-02433-6. Epub 2019 Nov 26.

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