General Information of HIF (ID: HIFC0169)
HIF Name	Kupffer macrophages
HIF Synonym(s)	Kupffer macrophages
HIF Classification	Macrophages (Mac)
Description	Kupffer macrophages is a type of the immune cells.				[1]

Microbe Species (MIC) Regulated by This HIF
Bifidobacterium sp. (actinobacteria)			MIC00224
Description	Bifidobacterium can cause significant Kupffer cells hyperplasia.				[2]
Faecalibacterium sp. (firmicutes)			MIC00589
Description	Faecalibacterium can cause significant Kupffer cells hyperplasia.				[2]
Staphylococcus aureus (firmicutes)			MIC01208
Description	Kupffer macrophages plays an important role in capturing and eliminating Staphylococcus aureus.				[3]

References
1	A Protocol for the Comprehensive Flow Cytometric Analysis of Immune Cells in Normal and Inflamed Murine Non-Lymphoid Tissues.PLoS One. 2016 Mar 3;11(3):e0150606. doi: 10.1371/journal.pone.0150606. eCollection 2016.
2	Fecal Microbiota of Diarrhea-Predominant Irritable Bowel Syndrome Patients Causes Hepatic Inflammation of Germ-Free Rats and Berberine Reverses It Partially.Biomed Res Int. 2019 Apr 3;2019:4530203. doi: 10.1155/2019/4530203. eCollection 2019.
3	Human skin commensals augment Staphylococcus aureus pathogenesis.Nat Microbiol. 2018 Aug;3(8):881-890. doi: 10.1038/s41564-018-0198-3. Epub 2018 Jul 16.

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