General Information of HIF (ID: HIFM0124)
HIF Name	Inducible T-cell costimulator
HIF Synonym(s)	AILIM, ICOS
HIF Classification	Checkpoint molecule (CM)
Description	ICOS is expressed on T cells to regulate responses to self-proteins.				[1]
Pfam	ICOS V-set domain (PF15910 )
Pathway	Cell adhesion molecules (CAMs) (hsa04514 )
	Intestinal immune network for IgA production (hsa04672 )
	Primary immunodeficiency (hsa05340 )
	T cell receptor signaling pathway (hsa04660 )
Sequence	Click here to download the HIF sequence in FASTA format
External Links
	Uniprot ID	ICOS_HUMAN

Microbe Species (MIC) Regulated by This HIF
Faecalibacterium sp. (firmicutes)			MIC00589
Description	The ICOS molecule is significantly up-regulated on CD41 T cells after ipilimumab treatment in patients who belong to Faecalibacterium-driven cluster A.				[2]

References
1	Molecular pathways: coexpression of immune checkpoint molecules: signaling pathways and implications for cancer immunotherapy.Clin Cancer Res. 2013 Sep 15;19(18):4917-24. doi: 10.1158/1078-0432.CCR-12-1972. Epub 2013 Jul 18.
2	Baseline gut microbiota predicts clinical response and colitis in metastatic melanoma patients treated with ipilimumab.Ann Oncol. 2019 Dec 1;30(12):2012. doi: 10.1093/annonc/mdz224.

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