Details of Microbe Species (MIC)

General Information of MIC (ID: MIC00666)
MIC Name Helicobacter hepaticus (epsilon-proteobacteria)
Body Site Gut
Lineage Kingdom: Bacteria
Phylum: Proteobacteria
Class: Epsilonproteobacteria
Order: Campylobacterales
Family: Helicobacteraceae
Genus: Helicobacter
Species: Helicobacter hepaticus
Oxygen Sensitivity Microaerophile
Microbial Metabolism Reduction
Gram Negative
Host Relationship Pathogen
Genome Size (bp) 1799146
Description Helicobacter hepaticus is a bacterium in the Helicobacteraceae family, Campylobacterales order. It has a spiral shape and bipolar, single, sheathed flagellum, and was first isolated from the livers of mice with active, chronic hepatitis. It is associated with colorectal cancer and other diseases.
External Links Taxonomy ID
32025
Genome Assembly ID
ASM790v1
GOLD Organism ID
Go0215893
Disease Relevance
          Chronic liver disease  [ICD-11: DB99]
             Description Antibodies to Helicobacter hepaticus, often cross reacting with H pylori, occured frequently in patients with chronic liver diseases, with no clear cut relation to specific diagnostic groups. [1]
Host Immune Factors (HIFs)
          Interferon-10
             HIF ID HIFM0128 HIF Info       Class Cytokine (Cyt)
             Description Helicobacter hepaticus proved that regulatory T cells directly inhibit the innate inflammatory response to lower bowel microbiota and delineated the critical role of IL-10. [2]
          Regulatory T cells
             HIF ID HIFC0030 HIF Info       Class T cells (TCs)
             Description Some regulatory T cells can inhibit and treat Helicobacter hepaticus-induced innate inflammation in the lower bowel, based on an IL-10-dependent mechanism. [2]
          ST2+GATA3+ regulatory T cells
             HIF ID HIFC0197 HIF Info       Class T cells (TCs)
             Description Helicobacter hepaticus is related to the ST2+GATA3+ Treg cells accumulation. [3]
          RORt+Foxp3+ regulatory T cells
             HIF ID HIFC0198 HIF Info       Class T cells (TCs)
             Description Host tolerance to Helicobacter hepaticus was mediated by induction of RORt+Foxp3+ regulatory T cells. [4]
Environmental Factor(s)
             Disbiome ID
      98
             gutMDisorder ID
      gm0364
References
1 Serum antibodies to Helicobacter hepaticus and Helicobacter pylori in patients with chronic liver disease. Gut. 2000 Mar;46(3):410-4. doi: 10.1136/gut.46.3.410.
2 Helicobacter hepaticus infection in mice: models for understanding lower bowel inflammation and cancer. Mucosal Immunol. 2011 Jan;4(1):22-30. doi: 10.1038/mi.2010.61. Epub 2010 Oct 13.
3 Development and maintenance of intestinal regulatory T cells.Nat Rev Immunol. 2016 May;16(5):295-309. doi: 10.1038/nri.2016.36. Epub 2016 Apr 18.
4 c-MAF-dependent regulatory T cells mediate immunological tolerance to a gut pathobiont.Nature. 2018 Feb 15;554(7692):373-377. doi: 10.1038/nature25500. Epub 2018 Feb 7.

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