Details of Microbe Species (MIC)

General Information of MIC (ID: MIC00192)
MIC Name Barnesiella intestinihominis (CFB bacteria)
Body Site Gut
Lineage Kingdom: Bacteria
Phylum: Bacteroidetes
Class: Bacteroidia
Order: Bacteroidales
Family: Barnesiellaceae
Genus: Barnesiella
Species: Barnesiella intestinihominis
Oxygen Sensitivity Anaerobe
Microbial Metabolism Saccharolytic; Fermentative
Gram Negative
Host Relationship Commensal
Genome Size (bp) 3433706
Description Barnesiella intestinihominis is a Gram-negative, anaerobic and non-spore-forming bacterium from the genus of Barnesiella which has been isolated from human feces.
External Links Taxonomy ID
487174
Genome Assembly ID
Barn_inte_YIT_11860_V1
GOLD Organism ID
Go0006545
Disease Relevance
          Autism spectrum disorder  [ICD-11: 6A02]
             Description Barnesiella intestinihominis was significantly elevated in autistic children. [1]
Host Genetic Factors (HGFs)
          MIR21
             HGF ID HGF2332 HGF Info       Class Copy Number Variation: Gene Deletion (CNV-GDe)
             Description The deletion of MIR-21 was significantly reduced the proportion of Barnesiella (p-value<0.05). [2]
Host Immune Factors (HIFs)
          Interferon gamma
             HIF ID HIFM0260 HIF Info       Class Cytokine (Cyt)
             Description Barnesiella intestinihominis augmented the proportions of IFN-Gamma-producing. [3]
          Nucleotide binding oligomerization domain containing 2 signaling pathway
             HIF ID HIFP0029 HIF Info       Class Signaling pathway (SP)
             Description NOD2 could limite the bioactivity of Barnesiella intestinihominis. [3]
          Regulatory T cells
             HIF ID HIFC0030 HIF Info       Class T cells (TCs)
             Description Barnesiella intestinihominis is associated with Tregs responses. [3]
          CD4+ helper T cells
             HIF ID HIFC0068 HIF Info       Class T cells (TCs)
             Description The colon resident Gram Barnesiella intestinihominis boosted systemic polyfunctional Th1 cell responses. [3]
          CD8+ T cells
             HIF ID HIFC0073 HIF Info       Class T cells (TCs)
             Description Barnesiella intestinihominis induced the proliferation of CD8+ T cells residing in the epithelial layer. [3]
          Gammadelta+ T cells
             HIF ID HIFC0077 HIF Info       Class T cells (TCs)
             Description Barnesiella intestinihominis accumulated in the colon and promoted the infiltration of IFN-g-producing gammadeta T cells in cancer lesions. [3]
Environmental Factor(s)
             Disbiome ID
      610
             gutMDisorder ID
      gm0096
References
1 The Possible Role of the Microbiota-Gut-Brain-Axis in Autism Spectrum Disorder. Int J Mol Sci. 2019 Apr 29;20(9):2115. doi: 10.3390/ijms20092115.
2 Loss of MicroRNA-21 Influences the Gut Microbiota, Causing Reduced Susceptibility in a Murine Model of Colitis.J Crohns Colitis. 2018 Jun 28;12(7):835-848. doi: 10.1093/ecco-jcc/jjy038.
3 Enterococcus hirae and Barnesiella intestinihominis Facilitate Cyclophosphamide-Induced Therapeutic Immunomodulatory Effects. Immunity. 2016 Oct 18;45(4):931-943. doi: 10.1016/j.immuni.2016.09.009. Epub 2016 Oct 4.

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