General Information of HIF (ID: HIFC0077)
HIF Name	Gammadelta+ T cells
HIF Synonym(s)	gammadelta+T cell, Gammadelta+ T cells
HIF Classification	T cells (TCs)
Description	Gamma delta T cells are the prototype of unconventional T cells and represent a relatively small subset of T cells in peripheral blood. They are defined by expression of heterodimeric T-cell receptors (TCRs) composed of and chains.				[1]

Microbe Species (MIC) Regulated by This HIF
Barnesiella intestinihominis (CFB bacteria)			MIC00192
Description	Barnesiella intestinihominis accumulated in the colon and promoted the infiltration of IFN-g-producing gammadeta T cells in cancer lesions.				[2]
Clostridium butyricum (firmicutes)			MIC00388
Description	Intracellular staining for cytokine profile of T cells from the pancreas demonstrated a lower percentage of IFN-gamma+ in non-obese diabetic disease with Clostridium butyricum CGMCC0313.1 infection.				[3]
Eubacterium saphenum (firmicutes)			MIC00579
Description	Intracellular production of IL-4/IFN-gamma in gammadelta T cells was the main response after injection of Eubacterium saphenum.				[4]
Glaesserella parasuis (gamma-proteobacteria)			MIC00654
Description	GammaDelte T-cells were found in reduced numbers after challenge with a lethal dose of a highly virulent Haemophilus parasuis strain.				[5]
Listeria monocytogenes (firmicutes)			MIC00771
Description	Listeria monocytogenes is associated with GammaDelte T cells responses.				[6]

References
1	Analytical performance of an automated volumetric flow cytometer for quantitation of T, B and natural killer lymphocytes.Clin Chem Lab Med. 2018 Jul 26;56(8):1277-1288. doi: 10.1515/cclm-2017-0638.
2	Enterococcus hirae and Barnesiella intestinihominis Facilitate Cyclophosphamide-Induced Therapeutic Immunomodulatory Effects. Immunity. 2016 Oct 18;45(4):931-943. doi: 10.1016/j.immuni.2016.09.009. Epub 2016 Oct 4.
3	Clostridium butyricum CGMCC0313.1 Protects against Autoimmune Diabetes by Modulating Intestinal Immune Homeostasis and Inducing Pancreatic Regulatory T Cells. Front Immunol. 2017 Oct 19;8:1345. doi: 10.3389/fimmu.2017.01345. eCollection 2017.
4	Intraperitoneal immune cell responses to Eubacterium saphenum in mice. Microbiol Immunol. 2001;45(1):29-37. doi: 10.1111/j.1348-0421.2001.tb01271.x.
5	Haemophilus parasuis: infection, immunity and enrofloxacin. Vet Res. 2015 Oct 28;46:128. doi: 10.1186/s13567-015-0263-3.
6	HDAC6 controls innate immune and autophagy responses to TLR-mediated signalling by the intracellular bacteria Listeria monocytogenes. PLoS Pathog. 2017 Dec 27;13(12):e1006799. doi: 10.1371/journal.ppat.1006799. eCollection 2017 Dec.

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