Details of Microbe Species (MIC)

General Information of MIC (ID: MIC00654)
MIC Name Glaesserella parasuis (gamma-proteobacteria)
MIC Synonyms Haemophilus parasuis
Body Site Nose
Lineage Kingdom: Bacteria
Phylum: Proteobacteria
Class: Gammaproteobacteria
Order: Pasteurellales
Family: Pasteurellaceae
Genus: Glaesserella
Species: Glaesserella parasuis
Oxygen Sensitivity Aerobe
Microbial Metabolism Respiratory
Gram Negative
Host Relationship Commensal
Genome Size (bp) 2269156
Description Glaesserella parasuis is an aerobic, Gram negative, small, pleomorphic, and fastidious rod.
External Links Taxonomy ID
738
Genome Assembly ID
ASM44468v1
GOLD Organism ID
Go0502039
Disease Relevance
          Autoimmune liver disease  [ICD-11: DB96]
             Description Haemophilus was associated with primary sclerosing cholangitis. [1]
          Ulcerative colitis  [ICD-11: DD71]
             Description Haemophilus was associated with primary sclerosing cholangitis. [1]
Host Genetic Factors (HGFs)
          A2ML1
             HGF ID HGF2326 HGF Info       Class Copy Number Variation: Gene Deletion (CNV-GDe)
             Description The duplication of A2ML1 could increase relative abundances of Haemophilus (p-value<0.05). [2]
          AMY1A
             HGF ID HGF2311 HGF Info       Class Copy Number Variation: Gene Duplication (CNV-GDu)
             Description Oral microbiome Haemophilus differs between high AMY1-CN and low AMY1-CN groups at the OTU level (p-value<0.05). [3]
          rs938421
             HGF ID HGF2098 HGF Info       Class Single Nucleotide Polymorphism (SNP)
             Description The rs938421 SNP was significantly associated with the abundance of Haemophilus (p-value=3.33E-06). [4]
          rs8107969
             HGF ID HGF1226 HGF Info       Class Single Nucleotide Polymorphism: Synonymous variant (SNP-SV)
             Description The rs8107969 SNP is significantly associated with the abundance of Haemophilus (p-value=5.05009E-07). [5]
          rs6007059
             HGF ID HGF2099 HGF Info       Class Single Nucleotide Polymorphism (SNP)
             Description The rs6007059 SNP is significantly associated with the abundance of gut microbiota Haemophilus (p-value<5.00E-05). [6]
          rs3808393
             HGF ID HGF1788 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs3808393 SNP is significantly associated with the abundance of Haemophilus (p-value=4.68E-06). [4]
          rs2288868
             HGF ID HGF1227 HGF Info       Class Single Nucleotide Polymorphism: Missense variant (SNP-MV)
             Description The rs2288868 SNP is significantly associated with the abundance of Haemophilus (p-value=5.05009E-07). [5]
          rs2166343
             HGF ID HGF2041 HGF Info       Class Single Nucleotide Polymorphism (SNP)
             Description The rs2166343 SNP is significantly associated with the abundance of Haemophilus (p-value=1.66E-07). [4]
          rs16880682
             HGF ID HGF2026 HGF Info       Class Single Nucleotide Polymorphism (SNP)
             Description The rs16880682 SNP is significantly associated with the abundance of gut microbiota Haemophilus (p-value<5.00E-05). [6]
          rs1443930
             HGF ID HGF1373 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs1443930 SNP is significantly associated with the abundance of Haemophilus (p-value=6.11E-06). [4]
          rs1126828
             HGF ID HGF1375 HGF Info       Class Single Nucleotide Polymorphism: Synonymous variant (SNP-SV)
             Description The rs1126828 SNP is significantly associated with the abundance of Haemophilus (p-value=1.19E-06). [7]
          rs10898950
             HGF ID HGF1441 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs10898950 SNP is significantly associated with the abundance of gut microbiota Haemophilus (p-value<5.00E-05). [6]
Host Immune Factors (HIFs)
          Cathelicidin antimicrobial peptide
             HIF ID HIFM0014 HIF Info       Class Antimicrobial peptide (AMP)
             Description The Haemophilus-dominant profile was associated with higher risks of intensive care among infants with lower LL-37 expression levels. [8]
          Human lactoferricin
             HIF ID HIFM0237 HIF Info       Class Antimicrobial peptide (AMP)
             Description Human milk lactoferrin is a serine protease that could cleave Haemophilus surface proteins at arginine-rich sites. [9]
          Interferon-10
             HIF ID HIFM0128 HIF Info       Class Cytokine (Cyt)
             Description The protection conferred by NPAPT vaccines was enough to prevent an inflammatory reaction mediated by IL-10, making NPAPT antigen a suitable candidate to control Gl sser's disease caused by Haemophilus parasuis Nagasaki strain. [10]
          Interleukin-1 alpha
             HIF ID HIFM0137 HIF Info       Class Cytokine (Cyt)
             Description IL-1alpha expression increased in lung during Haemophilus parasuis infection. [10]
          Interferon-4
             HIF ID HIFM0149 HIF Info       Class Cytokine (Cyt)
             Description IL-4 was expressed in significantly(p < 0.05)higher levels in spleen, pharyngeal lymph nodes, lung and brain of survivors undergoing severe Glassers disease following Haemophilus parasuis infection. [10]
          Interferon-6
             HIF ID HIFM0151 HIF Info       Class Cytokine (Cyt)
             Description High amounts of IL-6 were producd by CD163+ monocytes during highly virulent Haemophilus parasuis infection. [10]
          C-X-C motif chemokine 8
             HIF ID HIFM0153 HIF Info       Class Cytokine (Cyt)
             Description The cytokines interleukin (IL)-8 can participate in the inflammatory response to Haemophilus parasuis. [10]
          Tumor necrosis factor
             HIF ID HIFM0226 HIF Info       Class Cytokine (Cyt)
             Description Challenged with highly virulent Haemophilus parasuis showed an increase proportion of CD163+ monocytes, which are able to produce high amounts of proinflammatory cytokines, such as TNF-, IL-1 and IL-6. [10]
          Interferon gamma
             HIF ID HIFM0260 HIF Info       Class Cytokine (Cyt)
             Description Increased IL-1alpha expression in lung has been reported in pigs undergoing severe Glasser s disease following Haemophilus parasuis infection, whereas IL-4, IL-10, tumor necrosis factor (TNF)-alpha, and interferon (IFN)-gamma were expressed in significantly higher levels in spleen, pharyngeal lymph nodes, lung and brain of survivors. [10]
          Interleukin-1
             HIF ID HIFM0263 HIF Info       Class Cytokine (Cyt)
             Description Challenged with highly virulent Haemophilus parasuis showed an increase proportion of CD163+ monocytes, which are able to produce high amounts of proinflammatory cytokines, such as TNF-, IL-1 and IL-6. [10]
          Immunoglobulin M
             HIF ID HIFM0266 HIF Info       Class Immunoglobulin (Ig)
             Description Haemophilus parasuis infection could active a humoral immune response, which is frequently associated with the development of a transient IgM response followed by a solid and progressively increasing IgG antibody response. [10]
          Immunoglobulin G1
             HIF ID HIFM0269 HIF Info       Class Immunoglobulin (Ig)
             Description The abundance of Haemophilus influenzae is associated with IgG1 response. [11]
          Immunoglobulin G
             HIF ID HIFM0270 HIF Info       Class Immunoglobulin (Ig)
             Description Haemophilus parasuis infection could active a humoral immune response, which is frequently associated with the development of a transient IgM response followed by a solid and progressively increasing IgG antibody response. [10]
          CD163+ monocytes
             HIF ID HIFC0025 HIF Info       Class Monocytes (Mono)
             Description Highly virulent Haemophilus parasuis showed an increase proportion of CD163+ monocytes, which are able to produce high amounts of proinflammatory cytokines, such as TNF-, IL-1 and IL-6. [10]
          CD8+ T cells
             HIF ID HIFC0073 HIF Info       Class T cells (TCs)
             Description CD8+T cells were significantly increased after challenge with Haemophilus parasuis. [10]
          Gammadelta+ T cells
             HIF ID HIFC0077 HIF Info       Class T cells (TCs)
             Description GammaDelte T-cells were found in reduced numbers after challenge with a lethal dose of a highly virulent Haemophilus parasuis strain. [10]
References
1 Distinct gut microbiota profiles in patients with primary sclerosing cholangitis and ulcerative colitis. World J Gastroenterol. 2017 Jul 7;23(25):4548-4558. doi: 10.3748/wjg.v23.i25.4548.
2 Middle ear microbiome differences in indigenous Filipinos with chronic otitis media due to a duplication in the A2ML1 gene.Infect Dis Poverty. 2016 Nov 1;5(1):97. doi: 10.1186/s40249-016-0189-7.
3 Human Salivary Amylase Gene Copy Number Impacts Oral and Gut Microbiomes.Cell Host Microbe. 2019 Apr 10;25(4):553-564.e7. doi: 10.1016/j.chom.2019.03.001.
4 Genetic Determinants of the Gut Microbiome in UK Twins.Cell Host Microbe. 2016 May 11;19(5):731-43. doi: 10.1016/j.chom.2016.04.017.
5 Whole exome sequencing analyses reveal gene-microbiota interactions in the context of IBD.Gut. 2020 Jul 10:gutjnl-2019-319706. doi: 10.1136/gutjnl-2019-319706. Online ahead of print.
6 Assessing the Relationship Between Gut Microbiota and Bone Mineral Density.Front Genet. 2020 Jan 31;11:6. doi: 10.3389/fgene.2020.00006. eCollection 2020.
7 Host genetic variation impacts microbiome composition across human body sites.Genome Biol. 2015 Sep 15;16(1):191. doi: 10.1186/s13059-015-0759-1.
8 Serum cathelicidin, nasopharyngeal microbiota, and disease severity among infants hospitalized with bronchiolitis.J Allergy Clin Immunol. 2017 Apr;139(4):1383-1386.e6. doi: 10.1016/j.jaci.2016.09.037. Epub 2016 Nov 12.
9 Human milk lactoferrin is a serine protease that cleaves Haemophilus surface proteins at arginine-rich sites.Mol Microbiol. 2003 Feb;47(3):607-17. doi: 10.1046/j.1365-2958.2003.03327.x.
10 Haemophilus parasuis: infection, immunity and enrofloxacin. Vet Res. 2015 Oct 28;46:128. doi: 10.1186/s13567-015-0263-3.
11 Are there any clinical indications for measuring IgG subclasses. Ann Clin Biochem. 2002 Jul;39(Pt 4):374-7. doi: 10.1258/000456302760042678.

If you find any error in data or bug in web service, please kindly report it to Dr. Tang and Dr. Mou.