General Information of HIF (ID: HIFC0025)
HIF Name	CD163+ monocytes
HIF Synonym(s)	CD163+ monocytes
HIF Classification	Monocytes (Mono)
Description	CD163 is a member of the scavenger receptor cysteine-rich family of proteins, accounting for the clearance of hemoglobin-haptoglobin complexes, which in turn fuel an anti-inflammatory response mediated by heme metabolites				[1]

Microbe Species (MIC) Regulated by This HIF
Glaesserella parasuis (gamma-proteobacteria)			MIC00654
Description	Highly virulent Haemophilus parasuis showed an increase proportion of CD163+ monocytes, which are able to produce high amounts of proinflammatory cytokines, such as TNF-, IL-1 and IL-6.				[2]

References
1	Monocyte CD163 and CD36 expression in human whole blood and isolated mononuclear cell samples: influence of different anticoagulants. Clin Vaccine Immunol. 2006 Jun;13(6):704-7. doi: 10.1128/CVI.00417-05.
2	Haemophilus parasuis: infection, immunity and enrofloxacin. Vet Res. 2015 Oct 28;46:128. doi: 10.1186/s13567-015-0263-3.

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