Details of Microbe Species (MIC)

General Information of MIC (ID: MIC00579)
MIC Name Eubacterium saphenum (firmicutes)
Body Site Oral Cavity
Lineage Kingdom: Bacteria
Phylum: Firmicutes
Class: Clostridia
Order: Clostridiales
Family: Clostridiales Family XIII. Incertae Sedis
Genus: Eubacterium
Species: Eubacterium saphenum
Oxygen Sensitivity Obligate anaerobe
Microbial Metabolism Saccharolytic; Fermentative
Gram Positive
Host Relationship Commensal
Genome Size (bp) 1084901
Description Eubacterium saphenum are asaccharolytic, anaerobic, Gram-positive rods (AAGPR). There have been only a few reports of AAGPR isolated from oral disease sites. AAGPR are difficult to culture. Thus in previous studies, they may have been overlooked because of their poorgrowth using conventional procedures.
External Links Taxonomy ID
51123
Genome Assembly ID
ASM16197v1
GOLD Organism ID
Go0004541
Disease Relevance
          Periapical periodontitis  [ICD-11: DA09]
             Description Pulpal pathosis was associated with Eubacterium saphenum. [1]
Host Immune Factors (HIFs)
          Interferon-4
             HIF ID HIFM0149 HIF Info       Class Cytokine (Cyt)
             Description The intracellular production of IL-4 in CD4+/CD8+ T cells was rather low during Eubacterium saphenum infection. [2]
          Interferon gamma
             HIF ID HIFM0260 HIF Info       Class Cytokine (Cyt)
             Description After injection of Eubacterium saphenum, the production of IFN-Gamma in CD4+/CD8+ T cells is rather low. [2]
          Neutrophils
             HIF ID HIFC0029 HIF Info       Class Granulocytes (Gra)
             Description Neutrophils appeared first in peritoneal exudates after the injection of Eubacterium saphenum. [2]
          Immunoglobulin M
             HIF ID HIFM0266 HIF Info       Class Immunoglobulin (Ig)
             Description Eubacterium saphenum could enhance the level of IgM. [2]
          Immunoglobulin G
             HIF ID HIFM0270 HIF Info       Class Immunoglobulin (Ig)
             Description The abundance of Eubacterium saphenum is associated with IgG immune response. [2]
          Macrophages
             HIF ID HIFC0020 HIF Info       Class Macrophages (Mac)
             Description Macrophages appeared in peritoneal exudates after the injection of Eubacterium saphenum. [2]
          T cells
             HIF ID HIFC0002 HIF Info       Class T cells (TCs)
             Description Neutrophils appeared first in peritoneal exudates after the injection of Eubacterium saphenum. [2]
          CD4+ regulatory T cells
             HIF ID HIFC0034 HIF Info       Class T cells (TCs)
             Description Low intracellular production of IL-4/IFN-gamma in CD4+ T cells was induced after injection of Eubacterium saphenum. [2]
          CD8+ T cells
             HIF ID HIFC0073 HIF Info       Class T cells (TCs)
             Description Low intracellular production of IL-4/IFN-gamma in CD8+ T cells was induced after injection of Eubacterium saphenum. [2]
          Gammadelta+ T cells
             HIF ID HIFC0077 HIF Info       Class T cells (TCs)
             Description Intracellular production of IL-4/IFN-gamma in gammadelta T cells was the main response after injection of Eubacterium saphenum. [2]
Environmental Factor(s)
             Disbiome ID
      702
References
1 Detection of Slackia exigua, Mogibacterium timidum and Eubacterium saphenum from pulpal and periradicular samples using the Polymerase Chain Reaction (PCR) method. Int Endod J. 2001 Sep;34(6):463-70. doi: 10.1046/j.1365-2591.2001.00419.x.
2 Intraperitoneal immune cell responses to Eubacterium saphenum in mice. Microbiol Immunol. 2001;45(1):29-37. doi: 10.1111/j.1348-0421.2001.tb01271.x.

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