Details of Host Immune Factor (HIF) Regulating Microbe Species (MIC)

General Information of HIF (ID: HIFP0029)
HIF Name
Nucleotide binding oligomerization domain containing 2 signaling pathway
HIF Synonym(s)
Nod2, Nod2 signaling pathway
HIF Classification
Signaling pathway (SP)
Description NOD2 - inflammatory signaling and NFkB activation Nucleotide-binding oligomerization domain-containing protein 2 (NOD2) is an intracellular pattern recognition receptor (PRR) that plays an important role in recognizing bacterial pathogens and initiating an immune response. As a PRR, NOD2 recogniz... Read full blog post. [1]
Microbe Species (MIC) Regulated by This HIF
         Barnesiella intestinihominis (CFB bacteria) MIC00192
             Description NOD2 could limite the bioactivity of Barnesiella intestinihominis. [2]
         Chlamydia pneumoniae (chlamydias) MIC00350
             Description The abundance of Chlamydophila pneumoniae is associated with NOD2 [3]
         Enterococcus faecium (firmicutes) MIC00549
             Description The abundance of Enterococcus faecium is associated with NOD2. [4]
         Flavonifractor plautii (firmicutes) MIC01414
             Description At the species level, Flavonifractor plautii is associated with Nod2. [5]
         Legionella pneumophila (gamma-proteobacteria) MIC00751
             Description NOD2 signaling can in response to Legionella pneumophila infection. [6]
         Leptospira interrogans (spirochaetes) MIC00759
             Description Innate immune memory through TLR2 and NOD2 contributes to the control of Leptospira interrogans infection [7]
         Parvimonas micra (firmicutes) MIC00964
             Description Parvimonas micra has the highest NOD2 stimulatory activity. [8]
References
1 The NOD2 signaling in peripheral macrophages contributes to neuropathic pain development.Pain. 2019 Jan;160(1):102-116. doi: 10.1097/j.pain.0000000000001383.
2 Enterococcus hirae and Barnesiella intestinihominis Facilitate Cyclophosphamide-Induced Therapeutic Immunomodulatory Effects. Immunity. 2016 Oct 18;45(4):931-943. doi: 10.1016/j.immuni.2016.09.009. Epub 2016 Oct 4.
3 Chlamydia pneumoniae Infection and Inflammatory Diseases. For Immunopathol Dis Therap. 2016;7(3-4):237-254. doi: 10.1615/ForumImmunDisTher.2017020161.
4 Enterococcus faecium secreted antigen A generates muropeptides to enhance host immunity and limit bacterial pathogenesis. Elife. 2019 Apr 10;8:e45343. doi: 10.7554/eLife.45343.
5 The microbiota protects against respiratory infection via GM-CSF signaling. Nat Commun. 2017 Nov 15;8(1):1512. doi: 10.1038/s41467-017-01803-x.
6 Innate immunity to legionella pneumophila. Front Microbiol. 2011 May 16;2:109. doi: 10.3389/fmicb.2011.00109. eCollection 2011.
7 Innate immune memory through TLR2 and NOD2 contributes to the control of Leptospira interrogans infection. PLoS Pathog. 2019 May 20;15(5):e1007811. doi: 10.1371/journal.ppat.1007811. eCollection 2019 May.
8 TLR4, NOD1 and NOD2 mediate immune recognition of putative newly identified periodontal pathogens. Mol Oral Microbiol. 2016 Jun;31(3):243-258. doi: 10.1111/omi.12116. Epub 2015 Sep 10.

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