Details of Microbe Species (MIC)

General Information of MIC (ID: MIC01414)
MIC Name Flavonifractor plautii (firmicutes)
MIC Synonyms Fusobacterium plautii
Body Site Gut
Lineage Kingdom: Bacteria
Phylum: Firmicutes
Class: Clostridia
Order: Clostridiales
Family: Ruminococcaceae
Genus: Flavonifractor
Species: Flavonifractor plautii
Oxygen Sensitivity Facultative anaerobe
Microbial Metabolism Saccharolytic; Respiratory or Fermentative
Gram Positive
Host Relationship Commensal
Genome Size (bp) 3818500
No. of Coding Genes 3507
No. of Non-Coding Genes 65
No. of Small Non-Coding Genes 65
No. of Gene Transcripts 3638
No. of Pseudogenes 66
No. of Base Pairs 3818500
Description Flavonifractor plautii (formerly Eubacterium plautii) is an anaerobic, Gram positive, rod-shaped bacterium belonging to the family of Clostridiales, and a common member of the human gut microbiome. However, it is very rarely isolated from clinical human specimens, so data about its clinical significance are scarce.
External Links Taxonomy ID
292800
Genome Assembly ID
ASM168862v1
GOLD Organism ID
Go0000911
Disease Relevance
          Inflammatory bowel disease  [ICD-11: DD72]
             Description Flavonifractor plautii is associated with inflammatory bowel disease. [1]
Host Immune Factors (HIFs)
          Granulocyte-macrophage colony-stimulating factor
             HIF ID HIFM0066 HIF Info       Class Cytokine (Cyt)
             Description Flavonifractor plautii is associated with granulocyte-macrophage colony-stimulating factor (GM-CSF) signaling. [2]
          Immunoglobulin G
             HIF ID HIFM0270 HIF Info       Class Immunoglobulin (Ig)
             Description Flavonifractor is associated with IgG response. [3]
          Macrophages
             HIF ID HIFC0020 HIF Info       Class Macrophages (Mac)
             Description Flavonifractor plautii enhanced respiratory defenses via granulocyte-macrophages colony-stimulating factor (GM-CSF) signaling. [2]
          Nucleotide binding oligomerization domain containing 2 signaling pathway
             HIF ID HIFP0029 HIF Info       Class Signaling pathway (SP)
             Description At the species level, Flavonifractor plautii is associated with Nod2. [2]
Environmental Factor(s)
             Disbiome ID
      178
             gutMDisorder ID
      gm0339
References
1 Host immunoglobulin G selectively identifies pathobionts in pediatric inflammatory bowel diseases. Microbiome. 2019 Jan 3;7(1):1. doi: 10.1186/s40168-018-0604-3.
2 The microbiota protects against respiratory infection via GM-CSF signaling. Nat Commun. 2017 Nov 15;8(1):1512. doi: 10.1038/s41467-017-01803-x.
3 The imbalance of gut microbiota and its correlation with plasma inflammatory cytokines in pemphigus vulgaris patients. Scand J Immunol. 2019 Sep;90(3):e12799. doi: 10.1111/sji.12799. Epub 2019 Jul 8.

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