Details of Host Immune Factor (HIF) Regulating Microbe Species (MIC)

General Information of HIF (ID: HIFM0066)
HIF Name
Granulocyte-macrophage colony-stimulating factor
HIF Synonym(s)
colony stimulating factor 2, CSF2, CSF, GMCSF
HIF Classification
Cytokine (Cyt)
Molecular Function
Cytokine; Growth factor
Description Entrez Gene Summary for CSF2 Gene The protein encoded by this gene is a cytokine that controls the production, differentiation, and function of granulocytes and macrophages. The active form of the protein is found extracellularly as a homodimer. [1]
Pfam Granulocyte-macrophage colony-stimulating factor (PF01109 )
Pathway Acute myeloid leukemia (hsa05221 )
Amoebiasis (hsa05146 )
Cytokine-cytokine receptor interaction (hsa04060 )
Fc epsilon RI signaling pathway (hsa04664 )
Hematopoietic cell lineage (hsa04640 )
Human T-cell leukemia virus 1 infection (hsa05166 )
IL-17 signaling pathway (hsa04657 )
JAK-STAT signaling pathway (hsa04630 )
Kaposi sarcoma-associated herpesvirus infection (hsa05167 )
Natural killer cell mediated cytotoxicity (hsa04650 )
Rheumatoid arthritis (hsa05323 )
Shigellosis (hsa05131 )
T cell receptor signaling pathway (hsa04660 )
TNF signaling pathway (hsa04668 )
Transcriptional misregulation in cancer (hsa05202 )
Sequence Click here to download the HIF sequence in FASTA format
External Links
Uniprot ID
CSF2_HUMAN
Microbe Species (MIC) Regulated by This HIF
         Flavonifractor plautii (firmicutes) MIC01414
             Description Flavonifractor plautii is associated with granulocyte-macrophage colony-stimulating factor (GM-CSF) signaling. [2]
         Streptococcus thermophilus (firmicutes) MIC01272
             Description Streptococcus thermophilus decreased the mRNA expression of CSF-2. [3]
References
1 A Novel Endogenous Damage Signal, CSF-2, Activates Multiple Beneficial Functions of Adipose Tissue-Derived Mesenchymal Stem Cells.Mol Ther. 2019 Jun 5;27(6):1087-1100. doi: 10.1016/j.ymthe.2019.03.010. Epub 2019 Mar 19.
2 The microbiota protects against respiratory infection via GM-CSF signaling. Nat Commun. 2017 Nov 15;8(1):1512. doi: 10.1038/s41467-017-01803-x.
3 Streptococcus thermophilus alters the expression of genes associated with innate and adaptive immunity in human peripheral blood mononuclear cells. PLoS One. 2020 Feb 11;15(2):e0228531. doi: 10.1371/journal.pone.0228531. eCollection 2020.

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