| General Information of MIC (ID: MIC00759) |
| MIC Name |
Leptospira interrogans (spirochaetes)
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| MIC Synonyms |
Spirochaeta interrogans
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| Body Site |
Blood
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| Lineage |
Kingdom: Bacteria
Phylum: Spirochaetes
Class: Spirochaetia
Order: Leptospirales
Family: Leptospiraceae
Genus: Leptospira
Species: Leptospira interrogans
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| Oxygen Sensitivity |
Obligate aerobe
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| Microbial Metabolism |
Respiratory metabolism
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| Gram |
Negative
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| Description |
Leptospira interrogans is a Gram negative obligate aerobe. This bacterium is motile and has a spiral or helical shape like other spirochetes.
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| External Links |
Taxonomy ID |
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| Genome Assembly ID |
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| GOLD Organism ID |
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| Host Immune Factors (HIFs) |
| Macrophages |
| HIF ID |
HIFC0020 |
HIF Info
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Class |
Macrophages (Mac) |
| Description |
Macrophages play a key role in fighting infection and pathogen clearance of Leptospira interrogans. |
[1] |
| Nucleotide binding oligomerization domain containing 2 signaling pathway |
| HIF ID |
HIFP0029 |
HIF Info
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Class |
Signaling pathway (SP) |
| Description |
Innate immune memory through TLR2 and NOD2 contributes to the control of Leptospira interrogans infection |
[1] |
| Toll-like receptor 2 |
| HIF ID |
HIFM0217 |
HIF Info
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Class |
Toll-like receptor (TLR) |
| Description |
Innate immune memory through TLR2 contributes to the control of Leptospira interrogans infection. |
[1] |
| Toll-like receptor 4 |
| HIF ID |
HIFM0219 |
HIF Info
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Class |
Toll-like receptor (TLR) |
| Description |
TLR4-sensing deficiency could lead sensitivity to infection with Leptospira interrogans. |
[1] |
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| Environmental Factor(s) |
| Disbiome ID |
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| References |
| 1 |
Innate immune memory through TLR2 and NOD2 contributes to the control of Leptospira interrogans infection. PLoS Pathog. 2019 May 20;15(5):e1007811. doi: 10.1371/journal.ppat.1007811. eCollection 2019 May.
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