Details of Host Immune Factor (HIF) Regulating Microbe Species (MIC)

General Information of HIF (ID: HIFM0219)
HIF Name
Toll-like receptor 4
HIF Synonym(s)
toll like receptor 4, TLR4, TOLL, CD284, TLR-4, ARMD10
HIF Classification
Toll-like receptor (TLR)
Molecular Function
Hydrolase; Receptor
Description TLR4 (Toll Like Receptor 4) is a Protein Coding gene. [1]
Pfam Leucine Rich repeat (PF13516 )
Leucine rich repeat (PF13855 )
TIR domain (PF01582 )
Pathway Amoebiasis (hsa05146 )
Chagas disease (American trypanosomiasis) (hsa05142 )
HIF-1 signaling pathway (hsa04066 )
Hepatitis B (hsa05161 )
Human immunodeficiency virus 1 infection (hsa05170 )
Inflammatory bowel disease (IBD) (hsa05321 )
Influenza A (hsa05164 )
Legionellosis (hsa05134 )
Leishmaniasis (hsa05140 )
Malaria (hsa05144 )
Measles (hsa05162 )
NF-kappa B signaling pathway (hsa04064 )
NOD-like receptor signaling pathway (hsa04621 )
Necroptosis (hsa04217 )
PD-L1 expression and PD-1 checkpoint pathway in cancer (hsa05235 )
PI3K-Akt signaling pathway (hsa04151 )
Pathogenic Escherichia coli infection (hsa05130 )
Pertussis (hsa05133 )
Phagosome (hsa04145 )
Proteoglycans in cancer (hsa05205 )
Rheumatoid arthritis (hsa05323 )
Salmonella infection (hsa05132 )
Shigellosis (hsa05131 )
Toll-like receptor signaling pathway (hsa04620 )
Toxoplasmosis (hsa05145 )
Tuberculosis (hsa05152 )
Yersinia infection (hsa05135 )
Sequence Click here to download the HIF sequence in FASTA format
External Links
Uniprot ID
TLR4_HUMAN
Microbe Species (MIC) Regulated by This HIF
         Akkermansia muciniphila (verrucomicrobia) MIC00056
             Description Akkermansia muciniphila could activate the NF-B pathway through TLR4 and TLR2 receptors. [2]
         Bacillus subtilis (firmicutes) MIC00136
             Description Bacillus subtilis can stimulate the expression of TLR2 and TLR4. [3]
         Bacteroides thetaiotaomicron (CFB bacteria) MIC00179
             Description Bacteroides thetaiotaomicron LPS can stimulate cells via TLR4. [4]
         Campylobacter rectus (epsilon-proteobacteria) MIC00313
             Description TLR4 mediated intrauterine growth restriction after systemic Campylobacter rectus infection. [5]
         Chlamydia pneumoniae (chlamydias) MIC00350
             Description Chlamydophila pneumoniae infection of primary aortic endothelial cells results in enhanced production of granulocyte macrophage colony stimulating factor (GM-CSF) in a TLR4- dependent manner that may promote enhanced DC proliferation within the atherosclerotic lesions. [6]
         Citrobacter koseri (enterobacteria) MIC00365
             Description The microglial activation by Citrobacter koseri is mediated by TLR4- and MyD88-dependent pathways. [7]
         Clostridioides difficile (firmicutes) MIC00396
             Description TLR4 / mice had significantly (p<0.05) higher numbers of Clostridium difficile spores in the cecum after Clostridium difficile infection day 3. [8]
         Eubacterium limosum (firmicutes) MIC00576
             Description Eubacterium limosum can produce butyrate on the mucosal innate immune response via activate TLR4 system. [9]
         Lactobacillus rhamnosus (firmicutes) MIC00732
             Description The combination of iSN34 from Lactobacillus rhamnosus GG costimulated with agonists for TLR4 could inducte (in mouse splenocytes) of IL6. [10]
         Legionella pneumophila (gamma-proteobacteria) MIC00751
             Description TLR4 is a general LPS sensor,which would recognize Legionella pneumophila. [11]
         Leptospira interrogans (spirochaetes) MIC00759
             Description TLR4-sensing deficiency could lead sensitivity to infection with Leptospira interrogans. [12]
         Mycoplasma hyopneumoniae (mycoplasmas) MIC00872
             Description Tlr4 mediated the IgA immune response induced by Mycoplasma hyopneumoniae. [13]
         Plesiomonas shigelloides (enterobacteria) MIC00994
             Description Plesiomonas shigelloides could Stimulate the production of the proinflammatory cytokine TNF- (A) and IL-6 (B) by TLR4 / murine macrophages. [14]
         Rhizobium (alpha-proteobacteria) MIC01083
             Description Rhizobium is associated with TLR4 expression. [15]
         Serratia marcescens (enterobacteria) MIC01171
             Description Serratia marcescens induced corneal inflammation by activation of TLR4. [16]
         Spirochaetes (bacteria) MIC01204
             Description Oral Spirochaetes can make TLR4 activation in macrophages. [17]
         Streptococcus thermophilus (firmicutes) MIC01272
             Description Streptococcus thermophilus decreased mRNA expression of TLR4. [18]
         Treponema socranskii (spirochaetes) MIC01326
             Description Treponema socranskii as a TLR4 antagonist. [19]
         Veillonella parvula (firmicutes) MIC01365
             Description A TLR4 antagonist can block Veillonella parvula LPS-induced cytokine production. [20]
         Vibrio vulnificus (gamma-proteobacteria) MIC01378
             Description Vibrio vulnificus was associated with TLR4 expression. [21]
References
1 Inhibition of Toll-Like Receptor-4 (TLR-4) Improves Neurobehavioral Outcomes After Acute Ischemic Stroke in Diabetic Rats: Possible Role of Vascular Endothelial TLR-4.Mol Neurobiol. 2019 Mar;56(3):1607-1617. doi: 10.1007/s12035-018-1184-8. Epub 2018 Jun 16.
2 Pili-like proteins of Akkermansia muciniphila modulate host immune responses and gut barrier function. PLoS One. 2017 Mar 1;12(3):e0173004. doi: 10.1371/journal.pone.0173004. eCollection 2017.
3 Immunostimulatory activity of Bacillus spores. FEMS Immunol Med Microbiol. 2008 Jul;53(2):195-203. doi: 10.1111/j.1574-695X.2008.00415.x. Epub 2008 Apr 21.
4 The structurally similar, penta-acylated lipopolysaccharides of Porphyromonas gingivalis and Bacteroides elicit strikingly different innate immune responses. Microb Pathog. 2009 Aug;47(2):68-77. doi: 10.1016/j.micpath.2009.04.015. Epub 2009 May 19.
5 Toll-like receptor 4 mediates intrauterine growth restriction after systemic Campylobacter rectus infection in mice. Mol Oral Microbiol. 2012 Oct;27(5):373-81. doi: 10.1111/j.2041-1014.2012.00651.x. Epub 2012 Jun 9.
6 Chlamydia pneumoniae Infection and Inflammatory Diseases. For Immunopathol Dis Therap. 2016;7(3-4):237-254. doi: 10.1615/ForumImmunDisTher.2017020161.
7 MyD88 is pivotal for immune recognition of Citrobacter koseri and astrocyte activation during CNS infection. J Neuroinflammation. 2011 Apr 16;8:35. doi: 10.1186/1742-2094-8-35.
8 Immune responses to Clostridium difficile infection.Trends Mol Med. 2012 Nov;18(11):658-66. doi: 10.1016/j.molmed.2012.09.005. Epub 2012 Oct 16.
9 Eubacterium limosum ameliorates experimental colitis and metabolite of microbe attenuates colonic inflammatory action with increase of mucosal integrity. World J Gastroenterol. 2006 Feb 21;12(7):1071-7. doi: 10.3748/wjg.v12.i7.1071.
10 Immune synergistic oligodeoxynucleotide from Lactobacillus rhamnosus GG enhances the immune response upon co-stimulation by bacterial and fungal cell wall components. Anim Sci J. 2018 Oct;89(10):1504-1511. doi: 10.1111/asj.13082. Epub 2018 Jul 23.
11 Innate immunity to legionella pneumophila. Front Microbiol. 2011 May 16;2:109. doi: 10.3389/fmicb.2011.00109. eCollection 2011.
12 Innate immune memory through TLR2 and NOD2 contributes to the control of Leptospira interrogans infection. PLoS Pathog. 2019 May 20;15(5):e1007811. doi: 10.1371/journal.ppat.1007811. eCollection 2019 May.
13 Toll-Like Receptor 2 (TLR2) and TLR4 Mediate the IgA Immune Response Induced by Mycoplasma hyopneumoniae. Infect Immun. 2019 Dec 17;88(1):e00697-19. doi: 10.1128/IAI.00697-19. Print 2019 Dec 17.
14 Structure-Activity Relationship of Plesiomonas shigelloides Lipid A to the Production of TNF-, IL-1, and IL-6 by Human and Murine Macrophages. Front Immunol. 2017 Dec 11;8:1741. doi: 10.3389/fimmu.2017.01741. eCollection 2017.
15 Differential inductions of TNF-alpha and IGTP, IIGP by structurally diverse classic and non-classic lipopolysaccharides. Cell Microbiol. 2006 Mar;8(3):401-13. doi: 10.1111/j.1462-5822.2005.00629.x.
16 Innate immune regulation of Serratia marcescens-induced corneal inflammation and infection. Invest Ophthalmol Vis Sci. 2012 Oct 25;53(11):7382-8. doi: 10.1167/iovs.12-10238.
17 New insights into the emerging role of oral spirochaetes in periodontal disease. Clin Microbiol Infect. 2011 Apr;17(4):502-12. doi: 10.1111/j.1469-0691.2011.03460.x.
18 Streptococcus thermophilus alters the expression of genes associated with innate and adaptive immunity in human peripheral blood mononuclear cells. PLoS One. 2020 Feb 11;15(2):e0228531. doi: 10.1371/journal.pone.0228531. eCollection 2020.
19 Phenol/water extract of Treponema socranskii subsp. socranskii as an antagonist of Toll-like receptor 4 signalling. Microbiology. 2006 Feb;152(Pt 2):535-546. doi: 10.1099/mic.0.28470-0.
20 Receptor recognition of and immune intracellular pathways for Veillonella parvula lipopolysaccharide. Clin Vaccine Immunol. 2009 Dec;16(12):1804-9. doi: 10.1128/CVI.00310-09. Epub 2009 Oct 14.
21 Immunoinformatics design of a novel multi-epitope peptide vaccine to combat multi-drug resistant infections caused by Vibrio vulnificus. Eur J Pharm Sci. 2020 Jan 15;142:105160. doi: 10.1016/j.ejps.2019.105160. Epub 2019 Nov 18.

If you find any error in data or bug in web service, please kindly report it to Dr. Tang and Dr. Mou.