Details of Microbe Species (MIC)

General Information of MIC (ID: MIC01171)
MIC Name Serratia marcescens (enterobacteria)
MIC Synonyms Bacillus marcescens
Body Site Gut
Lineage Kingdom: Bacteria
Phylum: Proteobacteria
Class: Gammaproteobacteria
Order: Enterobacterales
Family: Yersiniaceae
Genus: Serratia
Species: Serratia marcescens
Oxygen Sensitivity Facultative anaerobe
Microbial Metabolism Fermentative; Respiratory
Gram Negative
Host Relationship Opportunistic pathogen
Genome Size (bp) 5113802
No. of Coding Genes 4756
No. of Non-Coding Genes 100
No. of Small Non-Coding Genes 100
No. of Gene Transcripts 4856
No. of Base Pairs 5298782
Description Serratia marcescens is a species of rod-shaped, Gram-negative bacteria, that is also a facultative anaerobic organism, classified as an opportunistic pathogen in the family Yersiniaceae. S. marcescens is commonly involved in hospital-acquired infections, particularly catheter-associated bacteremia, urinary tract infections, and wound infections. It is commonly found in the respiratory and urinary tracts of hospitalized adults and in the gastrointestinal systems of children.
External Links Taxonomy ID
615
Genome Assembly ID
ASM73853v1
GOLD Organism ID
Go0005520
Disease Relevance
          Granulomatous disease  [ICD-11: 4A00]
             Description Serratia marcescens can cause chronic granulomatous disease. [1]
          Meningococcal disease  [ICD-11: 1C1C]
             Description Serratia marcescens can cause nosocomial infections, particularly catheter-associated bacteremia. [2]
          Urinary tract infection  [ICD-11: GC08]
             Description Serratia marcescens is commonly involved in urinary tract infections. [3]
Host Genetic Factors (HGFs)
          hsa-miR-292-5p
             HGF ID HGF2365 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The miR-223 expression showed 2.65-fold up-regulation by Serratia marcescens infection. [4]
Host Immune Factors (HIFs)
          Interleukin-1 receptor type 1
             HIF ID HIFM0139 HIF Info       Class Cytokine (Cyt)
             Description Serratia marcescens induces corneal inflammation by activation of the IL-1R1 pathway. [5]
          Neutrophils
             HIF ID HIFC0029 HIF Info       Class Granulocytes (Gra)
             Description Neutrophils were recruited rapidly to the corneal stroma following Serratia marcescens infection, and S. marcescens was killed rapidly in the cornea following neutrophil infiltration. [5]
          Macrophages
             HIF ID HIFC0020 HIF Info       Class Macrophages (Mac)
             Description Serratia marcescens activated bone marrow derived macrophages. [5]
          Interleukin 1R1 signaling pathway
             HIF ID HIFP0014 HIF Info       Class Signaling pathway (SP)
             Description Serratia marcescens can replicate in the cornea and cause severe keratitis, under conditions where the TLR/interleukin-1 receptor type 1 (IL-1R1) signaling pathway is impaired. [5]
          MD-2 signaling pathway
             HIF ID HIFP0024 HIF Info       Class Signaling pathway (SP)
             Description Serratia marcescens could induce corneal inflammation by activation of MD-2 pathway. [5]
          Myeloid differentiation primary response 88 signaling pathway
             HIF ID HIFP0026 HIF Info       Class Signaling pathway (SP)
             Description Serratia marcescens could induce corneal inflammation by activation of MyD88 pathway. [5]
          Toll like receptor signaling pathway
             HIF ID HIFP0043 HIF Info       Class Signaling pathway (SP)
             Description Serratia marcescens can replicate in the cornea and cause severe keratitis, under conditions where the TLR/interleukin-1 receptor type 1 (IL-1R1) signaling pathway is impaired. [5]
          Toll like receptor 4 signaling pathway
             HIF ID HIFP0046 HIF Info       Class Signaling pathway (SP)
             Description Serratia marcescens could induce corneal inflammation by activation of TLR4 pathway. [5]
          Toll-like receptor 4
             HIF ID HIFM0219 HIF Info       Class Toll-like receptor (TLR)
             Description Serratia marcescens induced corneal inflammation by activation of TLR4. [5]
          Toll-like receptor 5
             HIF ID HIFM0220 HIF Info       Class Toll-like receptor (TLR)
             Description Serratia marcescens could induce corneal inflammation by activation of TLR5. [5]
Environmental Factor(s)
             Disbiome ID
      1641
             aBiofilm Organism
      Serratia marcescens
References
1 Chronic granulomatous disease. Br Med Bull. 2016 Jun;118(1):50-63. doi: 10.1093/bmb/ldw009. Epub 2016 Mar 16.
2 Draft genome sequence of Serratia marcescens strain LCT-SM213. J Bacteriol. 2012 Aug;194(16):4477-8. doi: 10.1128/JB.00933-12.
3 In vivo acquisition and risk of inter-species spread of bla (KPC-3)-plasmid from Klebsiella pneumoniae to Serratia marcescens in the lower respiratory tract. J Med Microbiol. 2020 Jan;69(1):82-86. doi: 10.1099/jmm.0.001113.
4 Whole blood-derived microRNA signatures in mice exposed to lipopolysaccharides. J Biomed Sci. 2012 Jul 31;19(1):69. doi: 10.1186/1423-0127-19-69.
5 Innate immune regulation of Serratia marcescens-induced corneal inflammation and infection. Invest Ophthalmol Vis Sci. 2012 Oct 25;53(11):7382-8. doi: 10.1167/iovs.12-10238.

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