Details of Host Immune Factor (HIF) Regulating Microbe Species (MIC)

General Information of HIF (ID: HIFM0220)
HIF Name
Toll-like receptor 5
HIF Synonym(s)
toll like receptor 5, MELIOS, SLE1, SLEB1, TIL3
HIF Classification
Toll-like receptor (TLR)
Molecular Function
Receptor
Description TLR5 is the receptor for bacterial flagellin [1]
Pfam Leucine rich repeat (PF13855 )
TIR domain (PF01582 )
Pathway Inflammatory bowel disease (IBD) (hsa05321 )
Legionellosis (hsa05134 )
Pathogenic Escherichia coli infection (hsa05130 )
Salmonella infection (hsa05132 )
Shigellosis (hsa05131 )
Toll-like receptor signaling pathway (hsa04620 )
Sequence Click here to download the HIF sequence in FASTA format
External Links
Uniprot ID
TLR5_HUMAN
Microbe Species (MIC) Regulated by This HIF
         Clostridioides difficile (firmicutes) MIC00396
             Description TLR5 stimulation could decrease Clostridium difficile-induced injury. [2]
         Corynebacterium diphtheriae (actinobacteria) MIC00452
             Description TLR5 is associated with the abundance of Corynebacterium diphtheriae. [3]
         Epsilonproteobacteria (epsilon-proteobacteria) MIC00553
             Description Epsilonproteobacteria was associated with TLR5. [4]
         Gammaproteobacteria (gamma-proteobacteria) MIC00624
             Description At the class level, Gammaproteobacteria is associated with TLR5. [5]
         Serratia marcescens (enterobacteria) MIC01171
             Description Serratia marcescens could induce corneal inflammation by activation of TLR5. [6]
References
1 All-trans retinoic acid induces TLR-5 expression and cell differentiation and promotes flagellin-mediated cell functions in human THP-1 cells.Immunol Lett. 2011 Apr 30;136(1):97-107. doi: 10.1016/j.imlet.2011.01.001. Epub 2011 Jan 13.
2 Immune responses to Clostridium difficile infection.Trends Mol Med. 2012 Nov;18(11):658-66. doi: 10.1016/j.molmed.2012.09.005. Epub 2012 Oct 16.
3 Bacterial flagellin and diphtheria toxin co-stimulate IL-17-producing thymocytes. Cytokine. 2013 Oct;64(1):221-6. doi: 10.1016/j.cyto.2013.06.318. Epub 2013 Aug 8.
4 Predictive computational modeling of the mucosal immune responses during Helicobacter pylori infection. PLoS One. 2013 Sep 5;8(9):e73365. doi: 10.1371/journal.pone.0073365. eCollection 2013.
5 IRF5 Is Required for Bacterial Clearance in Human M1-Polarized Macrophages, and IRF5 Immune-Mediated Disease Risk Variants Modulate This Outcome. J Immunol. 2019 Feb 1;202(3):920-930. doi: 10.4049/jimmunol.1800226. Epub 2018 Dec 28.
6 Innate immune regulation of Serratia marcescens-induced corneal inflammation and infection. Invest Ophthalmol Vis Sci. 2012 Oct 25;53(11):7382-8. doi: 10.1167/iovs.12-10238.

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