Details of Microbe Species (MIC)

General Information of MIC (ID: MIC00452)
MIC Name Corynebacterium diphtheriae (actinobacteria)
MIC Synonyms Bacillus diphtheriae
Body Site Skin
Lineage Kingdom: Bacteria
Phylum: Actinobacteria
Class: Actinobacteria
Order: Corynebacteriales
Family: Corynebacteriaceae
Genus: Corynebacterium
Species: Corynebacterium diphtheriae
Oxygen Sensitivity Aerobe
Microbial Metabolism Gluconeogenesis; Glycolysis
Gram Positive
Host Relationship Pathogen
Genome Size (bp) 2463666
No. of Coding Genes 2337
No. of Non-Coding Genes 56
No. of Small Non-Coding Genes 56
No. of Gene Transcripts 2393
No. of Base Pairs 2463666
Description Corynebacterium diphtheriae is a species of aerobic, Gram positive, nonmotile, toxin-producing, rod-shaped bacteria. It is best known for causing the disease Diphtheria in human beings.
External Links Taxonomy ID
1717
Genome Assembly ID
NCTC11397
GOLD Organism ID
Go0002782
Disease Relevance
          Diphtheria  [ICD-11: 1C17]
             Description Corynebacterium diphtheriae is a Gram-positive bacterial pathogen and the causative agent of diphtheria, a severe disease of the upper respiratory tract of humans. [1]
Host Immune Factors (HIFs)
          Immunoglobulin G
             HIF ID HIFM0270 HIF Info       Class Immunoglobulin (Ig)
             Description The abundance of Corynebacterium diphtheriae is associated with IgG immune response. [2]
          CD4+ regulatory T cells
             HIF ID HIFC0034 HIF Info       Class T cells (TCs)
             Description Corynebacterium diphtheriae was associated with CD4+T cells responses. [3]
          Toll-like receptor 5
             HIF ID HIFM0220 HIF Info       Class Toll-like receptor (TLR)
             Description TLR5 is associated with the abundance of Corynebacterium diphtheriae. [3]
Environmental Factor(s)
             Disbiome ID
      250
             gutMDisorder ID
      gm0233
References
1 Identification of zinc and Zur-regulated genes in Corynebacterium diphtheriae. PLoS One. 2019 Aug 27;14(8):e0221711. doi: 10.1371/journal.pone.0221711. eCollection 2019.
2 Are there any clinical indications for measuring IgG subclasses. Ann Clin Biochem. 2002 Jul;39(Pt 4):374-7. doi: 10.1258/000456302760042678.
3 Bacterial flagellin and diphtheria toxin co-stimulate IL-17-producing thymocytes. Cytokine. 2013 Oct;64(1):221-6. doi: 10.1016/j.cyto.2013.06.318. Epub 2013 Aug 8.

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