General Information of MIC (ID: MIC00624)
MIC Name	Gammaproteobacteria (gamma-proteobacteria)
MIC Synonyms	Proteobacteria gamma subdivision
Body Site	Blood
Lineage	Kingdom: Bacteria Phylum: Proteobacteria Class: Gammaproteobacteria
Oxygen Sensitivity	Facultative anaerobe
Microbial Metabolism	Carbohydrate metabolism
Gram	Negative
Host Relationship	Commensal
Description	The Gammaproteobacteria is a class of bacteria. Several medically, ecologically, and scientifically important groups of bacteria belong to this class. The Gammaproteobacteria is Gram-negative.
External Links	Taxonomy ID	1236
	GOLD Organism ID	Go0545884
Disease Relevance
Upper respiratory infection  [ICD-11: CA07]
Description	Gammaproteobacteria benefited from airway inflammation.				[1]

Host Genetic Factors (HGFs)
rs9300430
HGF ID	HGF1636	HGF Info	Class	Single Nucleotide Polymorphism: Intron variant (SNP-IV)
Description	The rs9300430 SNP was significantly associated with the abundance of Gammaproteobacteria (p-value=1.30E-9).				[2]
rs7134375
HGF ID	HGF1645	HGF Info	Class	Single Nucleotide Polymorphism: Non coding transcript variant (SNP-NCTV)
Description	The rs7134375 SNP was significantly associated with the abundance of Gammaproteobacteria(p-value=6.70E-05).				[3]
rs4621152
HGF ID	HGF1656	HGF Info	Class	Single Nucleotide Polymorphism: Intron variant (SNP-IV)
Description	The rs4621152 SNP was significantly associated with the abundance of Gammaproteobacteria (p-value=1.40E-8).				[2]

Host Immune Factors (HIFs)
AKT Serine Kinase 2 signaling pathway/AKT Threonine Kinase 2 signaling pathway
HIF ID	HIFP0003	HIF Info	Class	Signaling pathway (SP)
Description	At the class level, Gammaproteobacteria is associated with Akt2.				[4]
Nuclear factor kappa B signaling pathway
HIF ID	HIFP0028	HIF Info	Class	Signaling pathway (SP)
Description	At the class level, Gammaproteobacteria is associated with NF-B.				[4]
Toll-like receptor 5
HIF ID	HIFM0220	HIF Info	Class	Toll-like receptor (TLR)
Description	At the class level, Gammaproteobacteria is associated with TLR5.				[4]

Environmental Factor(s)
Disbiome ID			368
gutMDisorder ID			gm0349

References
1	The respiratory tract microbiome and lung inflammation: a two-way street. Mucosal Immunol. 2017 Mar;10(2):299-306. doi: 10.1038/mi.2016.108. Epub 2016 Dec 14.
2	Genome-wide association analysis identifies variation in vitamin D receptor and other host factors influencing the gut microbiota.Nat Genet. 2016 Nov;48(11):1396-1406. doi: 10.1038/ng.3695. Epub 2016 Oct 10.
3	The Gut Microbiome Contributes to a Substantial Proportion of the Variation in Blood Lipids.Circ Res. 2015 Oct 9;117(9):817-24. doi: 10.1161/CIRCRESAHA.115.306807. Epub 2015 Sep 10.
4	IRF5 Is Required for Bacterial Clearance in Human M1-Polarized Macrophages, and IRF5 Immune-Mediated Disease Risk Variants Modulate This Outcome. J Immunol. 2019 Feb 1;202(3):920-930. doi: 10.4049/jimmunol.1800226. Epub 2018 Dec 28.

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