Details of Host Immune Factor (HIF) Regulating Microbe Species (MIC)

General Information of HIF (ID: HIFP0003)
HIF Name	AKT Serine Kinase 2 signaling pathway/AKT Threonine Kinase 2 signaling pathway
HIF Synonym(s)	Akt2, AKT2 signaling pathway
HIF Classification	Signaling pathway (SP)
Description	Akt2 is a pivotal player in a complex web of signaling pathways controlling cell growth, proliferation, and survival.	[1]

Microbe Species (MIC) Regulated by This HIF
Gammaproteobacteria (gamma-proteobacteria)		MIC00624
Description	At the class level, Gammaproteobacteria is associated with Akt2.		[2]

References
1	Implications of Akt2/Twist crosstalk on breast cancer metastatic outcome.Drug Discov Today. 2015 Sep;20(9):1152-8. doi: 10.1016/j.drudis.2015.06.010. Epub 2015 Jun 29.
2	IRF5 Is Required for Bacterial Clearance in Human M1-Polarized Macrophages, and IRF5 Immune-Mediated Disease Risk Variants Modulate This Outcome. J Immunol. 2019 Feb 1;202(3):920-930. doi: 10.4049/jimmunol.1800226. Epub 2018 Dec 28.

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