General Information of MIC (ID: MIC00553)
MIC Name	Epsilonproteobacteria (epsilon-proteobacteria)
MIC Synonyms	Proteobacteria epsilon subdivision
Body Site	Skin
Lineage	Kingdom: Bacteria Phylum: Proteobacteria Class: Epsilonproteobacteria
Oxygen Sensitivity	Anaerobe
Microbial Metabolism	Fermentative
Gram	Negative
Host Relationship	Pathogen
Description	Epsilonproteobacteria is a class of Proteobacteria. All species of this class are Gram-negative. The Epsilonproteobacteria consists of few known genera, mainly the curved to spirilloid Wolinella spp., Helicobacter spp., and Campylobacter spp. Most of the known species inhabit the digestive tracts of animals and serve as symbionts or pathogens.
External Links	Taxonomy ID	29547
	GOLD Organism ID	Go0512439
Disease Relevance
Irritable bowel syndrome  [ICD-11: DD91]
Description	Numbers of Epsilonproteobacteria reduced in irritable bowel syndrome than control.				[1]

Host Immune Factors (HIFs)
CD4+ helper T cells
HIF ID	HIFC0067	HIF Info	Class	T cells (TCs)
Description	CD4+ T helper cells were recognized as a dominant component of immune responses to Helicobacter pylori.				[2]
Toll-like receptor 5
HIF ID	HIFM0220	HIF Info	Class	Toll-like receptor (TLR)
Description	Epsilonproteobacteria was associated with TLR5.				[2]

Environmental Factor(s)
Disbiome ID			1099
gutMDisorder ID			gm0293

References
1	The gut microbiota and irritable bowel syndrome: friend or foe. Int J Inflam. 2012;2012:151085. doi: 10.1155/2012/151085. Epub 2012 Apr 22.
2	Predictive computational modeling of the mucosal immune responses during Helicobacter pylori infection. PLoS One. 2013 Sep 5;8(9):e73365. doi: 10.1371/journal.pone.0073365. eCollection 2013.

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