Details of Host Immune Factor (HIF) Regulating Microbe Species (MIC)

General Information of HIF (ID: HIFC0067)
HIF Name
CD4+ helper T cells
HIF Synonym(s)
CD4+ helper T cell, CD4+ helper T cells
HIF Classification
T cells (TCs)
Description Helper T cells are also called CD4+ T cells, because they have on their surfaces a protein called CD4. Helper T cell s play a central role in normal immune responses by producing factors that activate virtually all the other immune system cells [1]
Microbe Species (MIC) Regulated by This HIF
         Epsilonproteobacteria (epsilon-proteobacteria) MIC00553
             Description CD4+ T helper cells were recognized as a dominant component of immune responses to Helicobacter pylori. [2]
         Mycoplasma hominis (mycoplasmas) MIC00871
             Description Mycoplasma hominis could promote the development of an IL-17-producing CD4+ helper T cell subset. [3]
         Staphylococcus aureus (firmicutes) MIC01208
             Description Staphylococcus aureus was associated with CD4+ T helper cells responses. [4]
         Tannerella forsythia (CFB bacteria) MIC01305
             Description Tannerella forsythia may induce pro-inflammatory cytokines such as IL-1 and IL-6 by CD4 + T helper cells. [5]
References
1 In Vitro Differentiation of Effector CD4(+) T Helper Cell Subsets.Methods Mol Biol. 2019;1960:75-84. doi: 10.1007/978-1-4939-9167-9_6.
2 Predictive computational modeling of the mucosal immune responses during Helicobacter pylori infection. PLoS One. 2013 Sep 5;8(9):e73365. doi: 10.1371/journal.pone.0073365. eCollection 2013.
3 Interaction of Mycoplasma hominis PG21 with Human Dendritic Cells: Interleukin-23-Inducing Mycoplasmal Lipoproteins and Inflammasome Activation of the Cell. J Bacteriol. 2017 Jul 11;199(15):e00213-17. doi: 10.1128/JB.00213-17. Print 2017 Aug 1.
4 Immune control of Staphylococcus aureus - regulation and counter-regulation of the adaptive immune response. Int J Med Microbiol. 2014 Mar;304(2):204-14. doi: 10.1016/j.ijmm.2013.11.008. Epub 2013 Dec 1.
5 The role of Tannerella forsythia and Porphyromonas gingivalis in pathogenesis of esophageal cancer. Infect Agent Cancer. 2019 Jan 30;14:3. doi: 10.1186/s13027-019-0220-2. eCollection 2019.

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