Details of Microbe Species (MIC)

General Information of MIC (ID: MIC01305)
MIC Name Tannerella forsythia (CFB bacteria)
MIC Synonyms Bacteroides forsythus
Body Site Vagina
Lineage Kingdom: Bacteria
Phylum: Bacteroidetes
Class: Bacteroidia
Order: Bacteroidales
Family: Tannerellaceae
Genus: Tannerella
Species: Tannerella forsythia
Oxygen Sensitivity Obligate anaerobe
Microbial Metabolism Asaccharolytic
Gram Negative
Genome Size (bp) 3405521
No. of Coding Genes 2491
No. of Non-Coding Genes 52
No. of Small Non-Coding Genes 52
No. of Gene Transcripts 2543
No. of Base Pairs 3281748
Description Tannerella forsythia is an obligate anaerobic, Gram negative member of the Cytophaga-Bacteroides family which was initially described as Bacteroides forsythus by Tanner et al. It has been implicated in periodontal diseases and is a member of the red complex of periodontal pathogens.
External Links Taxonomy ID
28112
Genome Assembly ID
ASM100648v1
GOLD Organism ID
Go0489314
Disease Relevance
          Periodontal disease  [ICD-11: DA0C]
             Description A small number of Bacteroides forsythus had been consistently associated with periodontitis. [1]
Host Genetic Factors (HGFs)
          MIR21
             HGF ID HGF2332 HGF Info       Class Copy Number Variation: Gene Deletion (CNV-GDe)
             Description The deletion of MIR-21 was significantly reduced the proportion of Tannerella (p-value<0.05). [2]
          hsa-miR-132-3p
             HGF ID HGF0267 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The level of miR-132 expression is associated with the abundance of Tannerella forsythia (p-value<0.05). [3]
          hsa-miR-146a-5p
             HGF ID HGF0252 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The level of miR-146a expression is associated with the abundance of Tannerella forsythia (p-value<0.05). [3]
          hsa-miR-155-5p
             HGF ID HGF0243 HGF Info       Class Non-coding RNA: Micro (ncRNA-miRNA)
             Description The level of miR-155 expression failed to be increased by Tannerella forsythia. [3]
          rs7465117
             HGF ID HGF1977 HGF Info       Class Single Nucleotide Polymorphism (SNP)
             Description The rs7465117 SNP was significantly associated with the abundance of Tannerella forsythia (p-value<1.00E-08). [4]
          rs6940
             HGF ID HGF1734 HGF Info       Class Single Nucleotide Polymorphism: Missense variant (SNP-MV)
             Description Haplotype blocks rs6940 was ignificantly associated with increased extent bleeding on probing and levels of microorganisms Tannerella forsythia (p0.05). [5]
          rs5743618
             HGF ID HGF1290 HGF Info       Class Single Nucleotide Polymorphism: Missense variant (SNP-MV)
             Description The rs5743618 SNP was significantly associated with the abundance of Tannerella forsythia (p-value=0.002). [6]
          rs419598
             HGF ID HGF1727 HGF Info       Class Single Nucleotide Polymorphism: Synonymous variant (SNP-SV)
             Description The polymorphic expression of IL-1RN rs419598 gene may be associated with a decreased load of Tannerella forsythia. [7]
          rs1057028
             HGF ID HGF1735 HGF Info       Class Single Nucleotide Polymorphism: Missense variant (SNP-MV)
             Description Haplotype blocks rs1057028 was ignificantly associated with increased extent bleeding on probing and levels of microorganisms Tannerella forsythia (p0.05). [5]
          rs369907
             HGF ID HGF1339 HGF Info       Class Single Nucleotide Polymorphism: Synonymous variant (SNP-SV)
             Description The rs369907 SNP was significantly associated with the abundance of Tannerella (p-value=1.08E-06). [8]
          rs2466613
             HGF ID HGF1652 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs2466613 SNP was significantly associated with the abundance of Tannerella (p-value=2.17E-06). [8]
          rs11188225
             HGF ID HGF1578 HGF Info       Class Single Nucleotide Polymorphism: Intron variant (SNP-IV)
             Description The rs11188225 SNP was significantly associated with the abundance of Tannerella (p-value=6.82E-06). [8]
Host Immune Factors (HIFs)
          Retinoic acid receptor responder protein2
             HIF ID HIFM0196 HIF Info       Class Antimicrobial peptide (AMP)
             Description There was a significant positive correlation between chemerin gene expression and abundance of Tannerella forsythia. [9]
          Interleukin-1 beta
             HIF ID HIFM0138 HIF Info       Class Cytokine (Cyt)
             Description Tannerella forsythia may induce pro-inflammatory cytokines such as IL-1beta. [10]
          Interferon-6
             HIF ID HIFM0151 HIF Info       Class Cytokine (Cyt)
             Description Tannerella forsythia may induce pro-inflammatory cytokines such as IL-6. [10]
          Interferon-7
             HIF ID HIFM0152 HIF Info       Class Cytokine (Cyt)
             Description Tannerella forsythia monocytes secrete pro-inflammatory cytokines, chemokines and VEGF with the release of IL-7 being differentially regulated by the two Tannerella forsythia wild-type strains. [11]
          C-X-C motif chemokine 8
             HIF ID HIFM0153 HIF Info       Class Cytokine (Cyt)
             Description Tannerella forsythia monocytes could produced IL-8. [11]
          Tumor necrosis factor
             HIF ID HIFM0226 HIF Info       Class Cytokine (Cyt)
             Description The presence of alpha tumor necrosis factor alpha (TNF-Alpha) can be generated by Tannerella forsythia. [10]
          Immunoglobulin G
             HIF ID HIFM0270 HIF Info       Class Immunoglobulin (Ig)
             Description Tannerella forsythia is associated with IgG response. [12]
          CD4+ helper T cells
             HIF ID HIFC0067 HIF Info       Class T cells (TCs)
             Description Tannerella forsythia may induce pro-inflammatory cytokines such as IL-1 and IL-6 by CD4 + T helper cells. [10]
Environmental Factor(s)
             Disbiome ID
      701
References
1 Association of Bacteroides forsythus and a novel Bacteroides phylotype with periodontitis. J Clin Microbiol. 2002 Mar;40(3):821-5. doi: 10.1128/jcm.40.3.821-825.2002.
2 Loss of MicroRNA-21 Influences the Gut Microbiota, Causing Reduced Susceptibility in a Murine Model of Colitis.J Crohns Colitis. 2018 Jun 28;12(7):835-848. doi: 10.1093/ecco-jcc/jjy038.
3 Polymicrobial infection alter inflammatory microRNA in rat salivary glands during periodontal disease. Anaerobe. 2016 Apr;38:70-75. doi: 10.1016/j.anaerobe.2015.10.005. Epub 2015 Oct 22.
4 Host genetic variation and its microbiome interactions within the Human Microbiome Project.Genome Med. 2018 Jan 29;10(1):6. doi: 10.1186/s13073-018-0515-8.
5 Common Polymorphisms in IFI16 and AIM2 Genes Are Associated With Periodontal Disease.J Periodontol. 2017 Jul;88(7):663-672. doi: 10.1902/jop.2017.160553. Epub 2017 Apr 7.
6 Associations of Toll-Like Receptor and -Defensin Polymorphisms with Measures of Periodontal Disease (PD) in HIV+ North American Adults: An Exploratory Study.PLoS One. 2016 Oct 11;11(10):e0164075. doi: 10.1371/journal.pone.0164075. eCollection 2016.
7 Polymorphism IL-1RN rs419598 reduces the susceptibility to generalized periodontitis in a population of European descent.PLoS One. 2017 Oct 12;12(10):e0186366. doi: 10.1371/journal.pone.0186366. eCollection 2017.
8 Host genetic variation impacts microbiome composition across human body sites.Genome Biol. 2015 Sep 15;16(1):191. doi: 10.1186/s13059-015-0759-1.
9 Antimicrobial and Attractant Roles for Chemerin in the Oral Cavity during Inflammatory Gum Disease.Front Immunol. 2017 Mar 29;8:353. doi: 10.3389/fimmu.2017.00353. eCollection 2017.
10 The role of Tannerella forsythia and Porphyromonas gingivalis in pathogenesis of esophageal cancer. Infect Agent Cancer. 2019 Jan 30;14:3. doi: 10.1186/s13027-019-0220-2. eCollection 2019.
11 Immune response profiling of primary monocytes and oral keratinocytes to different Tannerella forsythia strains and their cell surface mutants. Mol Oral Microbiol. 2018 Apr;33(2):155-167. doi: 10.1111/omi.12208. Epub 2018 Feb 7.
12 Serum IgG antibody levels to periodontal microbiota are associated with incident Alzheimer disease.PLoS One. 2014 Dec 18;9(12):e114959. doi: 10.1371/journal.pone.0114959. eCollection 2014.

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