General Information of HIF (ID: HIFM0152)
HIF Name	Interferon-7
HIF Synonym(s)	interleukin 7, IL7
HIF Classification	Cytokine (Cyt)
Molecular Function	Cytokine; Growth factor
Description	IL-7 is a hematopoietic growth factor that primarily affects early B and T cells. Produced by thymic stromal cells, spleen cells and keratinocytes, IL-7 can also co-stimulate the proliferation of mature T cells in combination with other factors, such as ConA and IL-2.				[1]
Pathway	Cytokine-cytokine receptor interaction (hsa04060 )
	Hematopoietic cell lineage (hsa04640 )
	JAK-STAT signaling pathway (hsa04630 )
	PI3K-Akt signaling pathway (hsa04151 )
	Pathways in cancer (hsa05200 )
Sequence	Click here to download the HIF sequence in FASTA format
External Links
	Uniprot ID	IL7_HUMAN

Microbe Species (MIC) Regulated by This HIF
Granulicatella adiacens (firmicutes)			MIC00645
Description	Granulicatella is positive correlation with IL-7 expression.				[2]
Tannerella forsythia (CFB bacteria)			MIC01305
Description	Tannerella forsythia monocytes secrete pro-inflammatory cytokines, chemokines and VEGF with the release of IL-7 being differentially regulated by the two Tannerella forsythia wild-type strains.				[3]

References
1	Harnessing the biology of IL-7 for therapeutic application.Nat Rev Immunol. 2011 May;11(5):330-42. doi: 10.1038/nri2970.
2	The imbalance of gut microbiota and its correlation with plasma inflammatory cytokines in pemphigus vulgaris patients. Scand J Immunol. 2019 Sep;90(3):e12799. doi: 10.1111/sji.12799. Epub 2019 Jul 8.
3	Immune response profiling of primary monocytes and oral keratinocytes to different Tannerella forsythia strains and their cell surface mutants. Mol Oral Microbiol. 2018 Apr;33(2):155-167. doi: 10.1111/omi.12208. Epub 2018 Feb 7.

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