Details of Microbe Species (MIC)

General Information of MIC (ID: MIC00871)
MIC Name Mycoplasma hominis (mycoplasmas)
MIC Synonyms Asterococcus hominis
Body Site Vagina
Lineage Kingdom: Bacteria
Phylum: Tenericutes
Class: Mollicutes
Order: Mycoplasmatales
Family: Mycoplasmataceae
Genus: Mycoplasma
Species: Mycoplasma hominis
Oxygen Sensitivity Obligate anaerobe
Microbial Metabolism Only ferment arginine
Gram Negative
Host Relationship Pathogen
Genome Size (bp) 695214
No. of Coding Genes 556
No. of Non-Coding Genes 42
No. of Small Non-Coding Genes 42
No. of Gene Transcripts 598
No. of Base Pairs 716440
Description Mycoplasma hominis is an obligate anaerobic, Gram negative bacterium. Mycoplasma hominis infection can cause urethritis and increases the risk of vaginitis and pelvic inflammatory disease in women. It is particularly harmful for people who are immune-compromised, e.g. those with AIDS or those on immunosuppressant drug therapy.
External Links Taxonomy ID
2098
Genome Assembly ID
ASM75938v1
GOLD Organism ID
Go0501649
Disease Relevance
          Vaginitis  [ICD-11: GA02]
             Description Mycoplasma hominis increased hugely in number in the case of bacterial vaginosis (BV). [1]
Host Immune Factors (HIFs)
          Interferon-12 subunit alpha
             HIF ID HIFM0130 HIF Info       Class Cytokine (Cyt)
             Description Mycoplasma hominis could stimulate the production of IL-12. [2]
          Interleukin-1 beta
             HIF ID HIFM0138 HIF Info       Class Cytokine (Cyt)
             Description Mycoplasma hominis induces caspase-dependent IL-1beta secretion. [2]
          Interleukin-23 subunit alpha
             HIF ID HIFM0144 HIF Info       Class Cytokine (Cyt)
             Description Mycoplasma hominis could induce a predominant IL-23 secretion. [2]
          Tumor necrosis factor
             HIF ID HIFM0226 HIF Info       Class Cytokine (Cyt)
             Description Mycoplasma hominis could stimulate the production of TNF-Alpha. [2]
          Dendritic cells
             HIF ID HIFC0003 HIF Info       Class Dendritic cells (DCs)
             Description A TX-114 extract of Mycoplasma hominis membranes induced the maturation of human dendritic cells (hDCs).And M. hominis lipoproteins could induce IL-23 production by hDCs. [2]
          CD4+ helper T cells
             HIF ID HIFC0067 HIF Info       Class T cells (TCs)
             Description Mycoplasma hominis could promote the development of an IL-17-producing CD4+ helper T cell subset. [2]
Environmental Factor(s)
             Disbiome ID
      788
References
1 Mollicutes in vaginal microbiology: Mycoplasma hominis, Ureaplasma urealyticum, Ureaplasma parvum and Mycoplasma genitalium. Res Microbiol. 2017 Nov-Dec;168(9-10):875-881. doi: 10.1016/j.resmic.2017.02.009. Epub 2017 Mar 2.
2 Interaction of Mycoplasma hominis PG21 with Human Dendritic Cells: Interleukin-23-Inducing Mycoplasmal Lipoproteins and Inflammasome Activation of the Cell. J Bacteriol. 2017 Jul 11;199(15):e00213-17. doi: 10.1128/JB.00213-17. Print 2017 Aug 1.

If you find any error in data or bug in web service, please kindly report it to Dr. Tang and Dr. Mou.