General Information of HIF (ID: HIFP0024)
HIF Name	MD-2 signaling pathway
HIF Synonym(s)	MD-2 pathway, MD-2 signaling pathway
HIF Classification	Signaling pathway (SP)
Description	Myeloid differentiation protein 2 (MD-2) are the main lipopolysaccharide (LPS) binding receptors that respond to inflammatory stimuli and mediate NF-kappa B (NF-B) signaling pathway in macrophages.				[1]

Microbe Species (MIC) Regulated by This HIF
Serratia marcescens (enterobacteria)			MIC01171
Description	Serratia marcescens could induce corneal inflammation by activation of MD-2 pathway.				[2]

References
1	Plasminogen activator inhibitor-1 regulates LPS-induced TLR4/MD-2 pathway activation and inflammation in alveolar macrophages. Inflammation. 2015 Feb;38(1):384-93. doi: 10.1007/s10753-014-0042-8.
2	Innate immune regulation of Serratia marcescens-induced corneal inflammation and infection. Invest Ophthalmol Vis Sci. 2012 Oct 25;53(11):7382-8. doi: 10.1167/iovs.12-10238.

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