Details of Host Immune Factor (HIF) Regulating Microbe Species (MIC)

General Information of HIF (ID: HIFP0026)
HIF Name
Myeloid differentiation primary response 88 signaling pathway
HIF Synonym(s)
MyD88 pathway, MyD88 signaling pathway
HIF Classification
Signaling pathway (SP)
Description The MyD88 protein is part of a signaling pathway that is involved in early recognition of pathogens and the initiation of inflammation to fight infection. This signaling pathway is part of the innate immune response. Mutations in the MYD88 gene lead to the production of a nonfunctional protein or no protein at all. [1]
Microbe Species (MIC) Regulated by This HIF
         Bacteroides sp. (CFB bacteria) MIC00176
             Description Clostridiales and Bacteroidales orders act to induce the transcription factor RORGammat in nascent Treg cells via an upstream MyD88-dependent mechanism to promote tolerance to dietary antigens. [2]
         Chlamydia pneumoniae (chlamydias) MIC00350
             Description Chlamydophila pneumoniae inflammatory responses are dependent on TLRs and the Myd88-dependent pathway. [3]
         Citrobacter koseri (enterobacteria) MIC00365
             Description MyD88-dependent signals are critical for bacterial containment and inflammatory mediator production during Citrobacter koseri brain infection. [4]
         Mycoplasma pneumoniae (mycoplasmas) MIC00875
             Description Proinflammatory gene upregulation during Mycoplasma pneumoniae infection is mediated by the MyD88/NF-kappaB pathway. [5]
         Rhizobium (alpha-proteobacteria) MIC01083
             Description The abundance of Rhizobium is associated with MyD88 signaling pathway. [6]
         Serratia marcescens (enterobacteria) MIC01171
             Description Serratia marcescens could induce corneal inflammation by activation of MyD88 pathway. [7]
References
1 Suppression of MyD88-dependent signaling alleviates neuropathic pain induced by peripheral nerve injury in the rat.J Neuroinflammation. 2017 Mar 31;14(1):70. doi: 10.1186/s12974-017-0822-9.
2 Regulation of oral immune tolerance by the microbiome in food allergy. Curr Opin Immunol. 2019 Oct;60:141-147. doi: 10.1016/j.coi.2019.06.001. Epub 2019 Jul 11.
3 Chlamydia pneumoniae Infection and Inflammatory Diseases. For Immunopathol Dis Therap. 2016;7(3-4):237-254. doi: 10.1615/ForumImmunDisTher.2017020161.
4 MyD88 is pivotal for immune recognition of Citrobacter koseri and astrocyte activation during CNS infection. J Neuroinflammation. 2011 Apr 16;8:35. doi: 10.1186/1742-2094-8-35.
5 NLRP3 Is a Critical Regulator of Inflammation and Innate Immune Cell Response during Mycoplasma pneumoniae Infection. Infect Immun. 2017 Dec 19;86(1):e00548-17. doi: 10.1128/IAI.00548-17. Print 2018 Jan.
6 Differential inductions of TNF-alpha and IGTP, IIGP by structurally diverse classic and non-classic lipopolysaccharides. Cell Microbiol. 2006 Mar;8(3):401-13. doi: 10.1111/j.1462-5822.2005.00629.x.
7 Innate immune regulation of Serratia marcescens-induced corneal inflammation and infection. Invest Ophthalmol Vis Sci. 2012 Oct 25;53(11):7382-8. doi: 10.1167/iovs.12-10238.

If you find any error in data or bug in web service, please kindly report it to Dr. Tang and Dr. Mou.